Life, Journal Year: 2024, Volume and Issue: 14(12), P. 1542 - 1542
Published: Nov. 25, 2024
This study investigated the multifaceted benefits of
Language: Английский
Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 353, P. 123276 - 123276
Published: Jan. 16, 2025
Language: Английский
Citations
6
Molecular Diagnosis & Therapy, Journal Year: 2023, Volume and Issue: 27(6), P. 723 - 739
Published: Sept. 22, 2023
Vitiligo is a chronic skin disorder characterised by the loss of melanocytes and subsequent depigmentation. Although many theories have been proposed in literature, none alone explains pathogenesis vitiligo. Oxidative stress has identified as potential factor A growing body evidence suggests that antioxidant therapies may offer promising approach to managing this condition. This review summarises mechanisms oxidative types melanocyte death We also provide brief overview most commonly studied antioxidants. Melanocytes vitiligo are thought be damaged an accumulation reactive oxygen species destroy structural functional integrity their DNA, lipids, proteins. Various causes, including exogenous endogenous factors, imbalance between prooxidants antioxidants, disruption pathways, gene polymorphisms, lead overproduction species. necroptosis, pyroptosis, ferroptosis, oxeiptosis newer cell contribute pathophysiology vitiligo, apoptosis remains mechanism According studies, vitamin E helps treat lipid peroxidation caused psoralen ultra-violet treatment. In addition, Polypodium leucotomos increased efficacy or narrow-band ultraviolet B therapy. Our provides valuable insights into role antioxidant-based supporting treating offering avenue for further research development effective treatment strategies.
Language: Английский
Citations
25
International Journal of Dermatology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 16, 2025
Few studies discuss the co-management of vitiligo and acquired hyperpigmentation disorders (AHD) such as melasma, erythema dyschromicum perstans, post-inflammatory hyperpigmentation, drug-induced lichen planus pigmentosus. This review discusses clinical examining strategies identifies current practice gaps. Dermatology Life Quality Index scores are higher in individuals with or melasma. It is plausible that populations experiencing both conditions may exhibit worsened psychological outcomes because stigmas perceived social beauty standards. Standard treatments for aim to increase pigmentation, while AHD target decreasing causing potential worsening contrast between multiple skin tones patients disorders. Tretinoin prevent narrowband ultraviolet B (NBUVB)-induced without altering treatment response also beneficial managing AHD. In addition, use oral tranexamic acid treat melasma does not diminish NBUVB phototherapy. Platelet-rich plasma (PRP) injections Polypodium leucotomos extract be comanaging However, guidelines needed optimize care this patient population.
Language: Английский
Citations
1
Antioxidants, Journal Year: 2022, Volume and Issue: 11(11), P. 2222 - 2222
Published: Nov. 11, 2022
The root bark of Morus alba L. (Mori Cortex) is used to treat diuresis and diabetes in Chinese traditional medicine. We evaluated different solvent extracts bioactive components from the for their antioxidant, anti-α-glucosidase, antityrosinase, anti-inflammatory activities. Acetone extract showed potent antioxidant activity, with SC50 values 242.33 ± 15.78 129.28 10.53 µg/mL DPPH ABTS radical scavenging assays, respectively. ethyl acetate exhibited strongest anti-α-glucosidase IC50 3.87 1.95 5.80 2.29 μg/mL, In antityrosinase assay, acetone excellent an value 7.95 1.54 μg/mL. test, significant anti-nitric oxide (NO) 10.81 1.41 12.00 1.32 content active compounds was examined compared by HPLC analysis. Six were isolated properties. Morin (1) oxyresveratrol (3) effective activities assays. Additionally, kuwanon H (6) highest among all isolates. Morusin (2) demonstrated more anti-NO anti-iNOS than positive control, quercetin. Our study suggests that should be further investigated as promising candidates treatment or prevention oxidative stress-related diseases, hyperglycemia, pigmentation disorders.
Language: Английский
Citations
23
Life, Journal Year: 2023, Volume and Issue: 13(7), P. 1513 - 1513
Published: July 5, 2023
Exposure to sun radiation leads higher risk of sunburn, pigmentation, immunosuppression, photoaging and skin cancer. In addition ultraviolet (UVR), recent research indicates that infrared (IR) visible light (VIS) can play an important role in the pathogenesis some these processes. Detrimental effects associated with exposure are well known, but new studies have shown DNA damage continues occur long after solar has ended. Regarding photoprotection strategies, natural substances emerging for topical oral photoprotection. this sense, Fernblock®, a standardized aqueous extract fern Polypodium Leucotomos (PLE), been widely administered both topically orally strong safety profile. Thus, used extensively clinical practice, including as complement photodynamic therapy (PDT) treating actinic keratoses (AKs) field cancerization. It also treat diseases such photodermatoses, photoaggravated inflammatory conditions pigmentary disorders. This review examines most developments application Fernblock® assesses how newly investigated action mechanisms may influence its use.
Language: Английский
Citations
10
Journal of Cosmetic Dermatology, Journal Year: 2024, Volume and Issue: 23(5), P. 1745 - 1752
Published: Feb. 19, 2024
Abstract Background Chronic nonextreme sun exposure induces two mechanisms of skin pigmentation, causing immediate darkening and delayed tanning. A new molecule, 2‐mercaptonicotinoyl glycine (2‐MNG), has been shown in vitro to inhibit both melanin synthesis via covalent conjugation the thiol group 2‐MNG precursors. Objective To evaluate preventing vivo. Methods In a randomized, intra‐individual controlled study, 33 subjects with melanin‐rich were exposed UV daylight on designated areas back treated cosmetic formula containing 0.5% or 1% alone association lipohydroxy acid (LHA, 0.3%) plus Mexoryl‐SX (MSX, 1.5%). The respective vehicles used as controls 4‐n‐butyl‐resorcinol (4‐n‐BR, 2.5%) positive reference. Results significantly reduced inhibited production when compared vehicle, higher performance at than 0.5%. LHA MSX showed alone. better 4‐n‐BR. Conclusions UV‐induced pigmentation highest efficacy induced by exposure.
Language: Английский
Citations
4
Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(2), P. 85 - 85
Published: Jan. 29, 2025
Chalcones are recognized for their diverse pharmacological properties, including anti-inflammatory and anti-melanogenic effects. However, studies on 2′-hydroxy-2-methoxychalcone derivatives remain limited. This study investigated the melanin synthesis-inhibitory effects of three derivatives: 2′-hydroxy-2,4-dimethoxychalcone (2,4-DMC), 2′-hydroxy-2,5′-dimethoxychalcone (2,5′-DMC), 2′-hydroxy-2,6′-dimethoxychalcone (2,6′-DMC). In lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages, 2,6′-DMC demonstrated a superior inhibition nitric oxide (NO) production, pro-inflammatory cytokines, expression inducible synthase (iNOS) cyclooxygenase-2 (COX-2) compared to other derivatives. A mechanistic analysis revealed that modulates NF-κB MAPK signaling pathways attenuate inflammation. Additionally, exhibited significant α-melanocyte-stimulating hormone (α-MSH)-induced synthesis in B16F10 melanoma cells by downregulating tyrosinase, TRP-1, TRP-2, MITF expression. regulation was achieved through suppression Wnt/β-catenin, PI3K/AKT, MAPK, PKA/CREB pathways. Compared 2,4-DMC 2,5′-DMC, 2,6′-DMC’s structural configuration, characterized methoxy groups at 2- 6′-positions, contributed its enhanced molecular stability binding affinity, amplifying inhibitory primary skin irritation test confirmed minimal irritation, demonstrating safety dermal applications. These findings suggest holds promise as dual-function agent managing inflammatory conditions hyperpigmentation-related disorders.
Language: Английский
Citations
0
Journal of Cosmetic Dermatology, Journal Year: 2025, Volume and Issue: 24(3)
Published: Feb. 27, 2025
ABSTRACT Objective Dry and chapped lips adversely affect both lip structure function, yet there is no established gold standard for their treatment. Herbal extracts present a promising alternative due to natural properties, though therapeutic potential care remains underexplored. This study aims develop clinically evaluate novel hydrant formulated with polyherbal extracts, the objective of offering an effective solution managing dry lips. Methods Six herbal eight mixtures, consisting at least three were evaluated cytotoxicity using MTT assay in HaCaT cells. The essential molecular markers examined by western blot analysis immunofluorescence assay. selected mixture was into tested randomized, double‐blind, controlled clinical trial. 66 Thai participants concerns randomly assigned two groups. Each participant applied either (test group) or petroleum gel (control once daily 28 days. Clinical assessments performed baseline on day post‐application. conditions, texture wrinkles, hemoglobin levels measured. Participant included ratings dryness, appearance, product satisfaction. Results demonstrated strengthening cell adherence, providing antioxidant effect, inducing self‐renewal. Mix2 shows most activity, increasing adherent protein stemness as active ingredient In trial, test control groups experienced significant reduction roughness compared ( p < 0.05). However, group exhibited significantly greater than No differences found between terms texture, wrinkle levels, levels. Notably, showed improvements perceived dryness 0.001). Conclusion findings support improving hydration, reducing roughness, alleviating ClinicalTrials.gov ID: NCT06475482).
Language: Английский
Citations
0
BMC Chemistry, Journal Year: 2023, Volume and Issue: 17(1)
Published: Nov. 19, 2023
Abstract Tyrosinase, the rate-limiting enzyme of melanogenesis, plays a crucial role in hyperpigmentation. As result, this study, novel class thiazolopyrimidine derivatives was developed and synthesized as tyrosinase inhibitor. The structure characterized using various spectroscopy techniques, including FTIR, Mass, 1 H-NMR, 13 C-NMR. Next, inhibitory activities all were examined against tyrosinase, and, 6a most potent compound, exhibited an IC 50 value 28.50 µM. Furthermore, kinetic study performed to better understand mechanism its type inhibition. UV/Vis spectra analysis also executed provide valuable evidence supporting compound context Also, molecular docking dynamic interactions within enzyme’s binding site.
Language: Английский
Citations
8
Current Protein and Peptide Science, Journal Year: 2024, Volume and Issue: 25(2), P. 183 - 188
Published: Jan. 17, 2024
Background: Melasma, oxidative stress, tyrosinase, antioxidants, Homogenized skin tissues, hyperpigmentation disease. Aims: To compare the levels of stress and tyrosinase activity in melasma patients with healthy volunteers. Methods: After written consent, 130 were enrolled a case–control study. 65 cases disorder, served as control. tissues taken used to estimate superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), peroxidase (GPx) (antioxidants), malondialdehyde (MDA) tyrosine hydroxylase (TH). Results: Melasma had lower basal systemic antioxidants than subjects. Tyrosinase was shown be greater lesional non-lesional skin. In controls, there good positive relationship between TH MDA an excellent negative GPx GSH. patients, significant associations CAT, GPx, SOD MDA. Conclusions: Increased may affect eumelanin synthesis via anabolic pathway melanin synthesis, according our findings. conclusion, we discovered activity.
Language: Английский
Citations
3