Green synthesis: an eco friendly approach for metallic nanoparticles synthesis

Particulate Science And Technology, Journal Year: 2023, Volume and Issue: 42(5), P. 874 - 894

Published: Nov. 16, 2023

Nanotechnology is an emerging field with diverse applications, wherein materials ranging in size from 1 to 100 nm, referred as nanoparticles (NPs), are utilized. Traditional methods for producing metallic NPs primarily involve chemical processes, which can result unintended outcomes. To overcome these challenges, a greener alternative, known green synthesis, has been developed. Green synthesis of emerged innovative and environmentally friendly approach nanotechnology. Utilizing plant extracts, microorganisms, biopolymers reducing stabilizing agents, researchers have successfully prepared various nanoparticles, such silver, copper, gold, platinum, palladium nanoparticles. These offer advantages like cost-effectiveness, reduced environmental impact, facile scalability. This method ensures eco-friendliness by implementing techniques the use safe, nontoxic solvents (such supercritical fluids water) additives polysaccharides. Different reaction conditions energy-saving growth also employed enhance sustainability. Nanoparticles synthesized through exhibit unique properties, rendering them highly suitable including catalysis, medicine, energy technologies. review paper explores recent advances biosynthesis at nanoscale highlights different factors that affect their possible applications

Language: Английский

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Chemico-pharmacological and computational studies of Ophiorrhiza fasciculata D. Don and Psychotria silhetensis Hook. f. focusing cytotoxic, thrombolytic, anti-inflammatory, antioxidant, and antibacterial properties

Heliyon, Journal Year: 2023, Volume and Issue: 9(9), P. e20100 - e20100

Published: Sept. 1, 2023

The current study sought to examine the pharmacological potentials of crude methanolic extracts Ophiorrhiza fasciculata and Psychotria silhetensis, as well their various solvent fractionates, with a focus on cytotoxic, thrombolytic, membrane stabilizing, antioxidant, antibacterial activities via in vitro silico approaches. extensive chromatographic spectroscopic analyses confirmed characterized two compounds (±)-licarin B (1) stigmasterol (2) from O. P. respectively. Petroleum ether soluble fraction aqueous silhetensis showed lowest 50% lethal concentrations (1.41 1.94 μg/mL, respectively) brine shrimp bioassay. Likewise, petroleum highest thrombolytic activity 46.66% 50.10% lyses clot, methanol dichloromethane fractions reduced erythrocyte hemolysis by 64.03% 37.08%, respectively, under hypotonic heat-induced conditions, compared 81.97% 42.12% for standard acetylsalicylic acid. In antioxidant test, (IC50 = 7.22 μg/mL) revealed promising potentialities comparison butylated hydroxytoluene 21.20 μg/mL). screening, chloroform, mild drug ciprofloxacin. Additionally, molecular docking corroborated findings, isolated constituents had higher binding affinities toward epidermal growth factor receptor, tissue plasminogen activator, vFLIP-IKK gamma stapled peptide dimer, glutathione reductase, dihydrofolate reductase enzyme than corresponding drugs. addition, both exerted favorable pharmacokinetics (absorption, distribution, metabolism, excretion) toxicological profiles drug-like qualities computational-based ADMET likeliness analyses. research suggests that plants have potential natural treatment treating thrombosis, inflammation, oxidative stress. However, more thorough is required thoroughly screen phytochemicals pinpoint precise mechanisms action bioactive metabolites derived these against broad range targets.

Language: Английский

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Rational approach to design gold nanoparticles for photothermal therapy: the effect of gold salt on physicochemical, optical and biological properties

International Journal of Pharmaceutics, Journal Year: 2023, Volume and Issue: 650, P. 123659 - 123659

Published: Nov. 30, 2023

Language: Английский

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An overview of phyto-assisted fabrication of metallic nanoparticles

Biocatalysis and Agricultural Biotechnology, Journal Year: 2023, Volume and Issue: 50, P. 102723 - 102723

Published: May 3, 2023

Language: Английский

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Exploring the potential anti-inflammatory effect of biosynthesized gold nanoparticles using Isodon excisus leaf tissue in human keratinocytes

Arabian Journal of Chemistry, Journal Year: 2023, Volume and Issue: 16(10), P. 105113 - 105113

Published: July 4, 2023

The skin plays a crucial role in maintaining hydration, preventing dehydration, and protecting against harmful microorganisms. Skin injury can lead to inflammation fluid loss, which are detrimental human health. Nanotechnology has been proposed as potential solution prevent damage because it more effectively penetrate the barrier deliver targeted treatments directly cells that require them. In this study, we biosynthesized gold nanoparticles (AuNPs) using Isodon excisus (Maxim.) Kudo (IE) leaf tissue. formation of IE (IE-AuNPs) was confirmed various techniques. Furthermore, cytotoxicity IE-AuNPs on keratinocytes (HaCaT cells) evaluated, found had no cytotoxic effect HaCaT (50 µg/mL). ability reduce investigated dark-field microscopy (DFM) enzyme-linked immunosorbent assay (ELISA). Real-time quantitative reverse transcription-polymerase chain reaction (qRT-PCR) used assess inflammatory biomarkers such IL-6, IL-8, CCL17/TARC, CCL27/CTACK, CCL5/RANTES. Additionally, western blotting demonstrated exhibited anti-inflammatory effects by activating autophagy inhibiting PI3K/AKT signaling pathway at upstream level. Overall, our findings suggest enhance be development nano-based for skin-related diseases.

Language: Английский

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<i>Tribulus terrestris</i> fruit’s potential for synthesizing gold nanoparticles with remarkable biological prospects

Journal of Biological Research - Bollettino della Società Italiana di Biologia Sperimentale, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Tribulus terrestris is a member of the family Zygophyllaceae commonly known as “puncture vine”. The plant has been used traditionally an analgesic and to relieve rheumatic pain, eye problems, sexual dysfunction edema. aim this work was test use T. fruit extract reducing agent in synthesizing gold nanoparticles (AuNPs), their biological activities, assess suitability therapeutic by testing them for potential adverse effects on human cells. Indeed, we have performed most comprehensive AuNPs produced using extracts date. aqueous dried powdered fruits reduction hydrogen tetrachloroaurate (III) trihydrate (AuCl4·3H2O). extract's phytochemical components effectively served reducing, capping stabilizing agents, resulting production consistent round-shaped with size range less than 100 nm. synthesized were subjected various physicochemical analyses, then evaluated antibacterial, antifungal antileishmanial activity, hemagglutination, cytotoxicity antioxidant bioassays. showed inhibition zones against several bacterial fungal strains, exhibited activity at high doses. demonstrated positive hemagglutination Red Blood Cells (RBCs) blood groups A B 10 20 µg/mL, but no AB O up 40 µg/mL. RBCs suggesting that they may be suitable clinical setting. 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, results indicated potential.

Language: Английский

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Myco-engineered Gold Nanoparticles and Their Employment as Biomedical Agents and Upscaling

Plasmonics, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Language: Английский

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Exploring Biomedical Potential of Phytochemical Synthesized Iron Nanoparticles: In Vivo and In Vitro Evaluation

Nano Biomedicine and Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Nano-Biofortification of Millets: A Review

Published: April 29, 2025

The world's population faces nutritional insecurity due to a reliance on grain-heavy diets low in micronutrients. In drought-prone regions of Asia and Africa, millets are crucial energy source, rich proteins, vital amino acids, minerals, vitamins. Biofortifying staple crops is cost-effective strategy combat micronutrient deficiencies, particularly impoverished areas where access supplements limited. While the green revolution boosted agricultural output, it often overlooked quality food. Biofortification using nanoparticles nanomaterials can enhance nutrient delivery improve crop health without significantly harming environment. Micronutrient-enriched nano fertilizers increase yields quality, especially for zinc iron. Studies indicate that nano-fertilizers utilization, reduce soil toxicity, decrease application frequency, making nanotechnology promising solution sustainable production, developing nations

Language: Английский

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Synergistic relationship of endophyte-nanomaterials to alleviate abiotic stress in plants

Frontiers in Environmental Science, Journal Year: 2022, Volume and Issue: 10

Published: Nov. 24, 2022

Plant responses to abiotic stresses through diverse mechanisms and strategic measures in utilizing nanomaterials have positively impacted crop productivity. Stress can cause membrane depletion, reactive oxygen species formation, cell toxicity death, reduction plant growth. However, mitigate some of the negative impacts enhance yield. Some endophytic microbes synthesize nanomaterials, which maintain health growth via nitrogen fixation, siderophore production, phytohormones synthesis, enzyme production without any pathological effects. Nanoparticle-synthesizing endophytes also help boost biochemical physiological functions by ameliorating impact stresses. The increase use implementation nano-growth enhancers from beneficial microbes, such as nano-biofertilizers, nano-pesticides, nano-herbicides, nano-fungicides are considered safe eco-friendly ensuring sustainable agriculture agrochemical usage. Promisingly, nanotechnology concepts aim sustain protect plants oxidative activation anti-oxidative enzymes. relieve stress still require further discussion literature. Therefore, this review is focused on induction tolerance plants,

Language: Английский

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