Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: June 26, 2023
Abstract
Growing
evidence
suggests
that
exposure
of
Bisphenol
A
(BPA),
an
endocrine
disruptor
commonly
presence
in
the
environment,
can
impair
reproduction.
However,
conflicting
results
have
been
reported
and
underling
mechanism
not
fully
understood.
In
this
study,
3
weeks
old
male
mice
were
exposed
to
50mg/kg/d
BPA
or
equivalent
corn
oil
for
28
days.
Their
testis
epididymis
then
collected
morphology
examination
by
HE
stains.
The
number
sperm
counted,
was
analyzed
PNA
pap
staining.
Fertilization
capacity
successful
rate
after
mating
with
wide
type
females.
Spermatid
DNA
damage
apoptosis
evaluated
DFI,
γH2AX
stain
TUNEL
assay.
RNA-seq
analysis
conducted
identify
differentially
expressed
genes
testicular
tissue
BPA.
RNA
interference
used
verify
regulatory
on
gene
expression
GC-2
cells.
Our
data
showed
total
decreased
impaired
BPA-exposed
mice.
addition,
serum
testosterone
level
fertilization
efficiency
also
reduced.
Mechanism
studies
could
suppress
PCBP2,
a
key
spermatid
development,
activating
EZH2/H3K27me3.
conclusion,
we
found
development
via
affecting
at
least
partially
due
epigenetic
modification.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: March 25, 2024
Abstract
The
innate
immune
pathway
is
receiving
increasing
attention
in
cancer
therapy.
This
ubiquitous
across
various
cell
types,
not
only
cells
but
also
adaptive
cells,
tumor
and
stromal
cells.
Agonists
targeting
the
have
shown
profound
changes
microenvironment
(TME)
improved
prognosis
preclinical
studies.
However,
to
date,
clinical
success
of
drugs
remains
limited.
Interestingly,
recent
studies
that
activation
can
paradoxically
promote
progression.
uncertainty
surrounding
therapeutic
effectiveness
targeted
for
a
critical
issue
needs
immediate
investigation.
In
this
review,
we
observe
role
demonstrates
heterogeneity,
linked
development
stage,
status,
specific
types.
We
propose
within
TME,
exhibits
multidimensional
diversity.
diversity
fundamentally
rooted
cellular
heterogeneity
manifested
as
variety
signaling
networks.
pro-tumor
effect
essentially
reflects
suppression
classical
pathways
potential
alternative
pathways.
Refining
our
understanding
tumor’s
network
employing
appropriate
strategies
enhance
ability
harness
anti-tumor
ultimately
bridge
gap
from
application.
Cell Death Discovery,
Journal Year:
2024,
Volume and Issue:
10(1)
Published: July 20, 2024
Abstract
Recently,
N6-methyladenosine
(m
6
A)
has
aroused
widespread
discussion
in
the
scientific
community
as
a
mode
of
RNA
modification.
m
A
comprises
writers,
erasers,
and
readers,
which
regulates
production,
nuclear
export,
translation
is
very
important
for
human
health.
large
number
studies
have
found
that
regulation
closely
related
to
occurrence
invasion
tumors,
while
homeostasis
function
tumor
microenvironment
(TME)
determine
development
tumors
some
extent.
TME
composed
variety
immune
cells
(T
cells,
B
etc.)
nonimmune
(tumor-associated
mesenchymal
stem
(TA-MSCs),
cancer-associated
fibroblasts
(CAFs),
etc.).
Current
suggest
involved
regulating
various
TME,
thereby
affecting
progression.
In
this
manuscript,
we
present
composition
relationship
between
methylation
characteristic
changes
role
potential
therapeutic
strategies
provide
new
perspectives
better
treatment
clinical
work.
Briefings in Bioinformatics,
Journal Year:
2023,
Volume and Issue:
25(1)
Published: Nov. 22, 2023
Abstract
N6-methyladenosine
(m6A)
RNA
methylation
is
the
predominant
epigenetic
modification
for
mRNAs
that
regulates
various
cancer-related
pathways.
However,
prognostic
significance
of
m6A
regulators
remains
unclear
in
glioma.
By
integrating
TCGA
lower-grade
glioma
(LGG)
and
glioblastoma
multiforme
(GBM)
gene
expression
data,
we
demonstrated
both
m6A-target
genes
were
associated
with
prognosis
activated
Then,
paired
their
target
as
m6A-related
pairs
(MGPs)
using
iPAGE
algorithm,
among
which
122
MGPs
significantly
reversed
between
LGG
GBM.
Subsequently,
employed
LASSO
Cox
regression
analysis
to
construct
an
MGP
signature
(MrGPS)
evaluate
prognosis.
MrGPS
was
independently
validated
CGGA
GEO
cohorts
high
accuracy
predicting
overall
survival.
The
average
area
under
receiver
operating
characteristic
curve
(AUC)
at
1-,
3-
5-year
intervals
0.752,
0.853
0.831,
respectively.
Combining
clinical
factors
age
radiotherapy,
AUC
much
improved
around
0.90.
Furthermore,
CIBERSORT
TIDE
algorithms
revealed
indicative
immune
infiltration
level
response
checkpoint
inhibitor
therapy
patients.
In
conclusion,
our
study
a
factor
developed
model
holds
potential
valuable
tool
enhancing
patient
management
facilitating
accurate
assessment
cases
Cellular and Molecular Neurobiology,
Journal Year:
2025,
Volume and Issue:
45(1)
Published: April 7, 2025
The
canonical
cyclic
GMP-AMP
(cGAMP)
synthase
(cGAS)-Stimulator
of
Interferon
Genes
(STING)
pathway
has
been
widely
recognized
as
a
crucial
mediator
inflammation
in
many
diseases,
including
tumors,
infections,
and
tissue
damage.
STING
signaling
can
also
be
activated
cGAS-
or
cGAMP-independent
manner,
although
the
specific
mechanisms
remain
unclear.
In-depth
studies
on
structural
molecular
biology
have
led
to
development
therapeutic
strategies
involving
modulators
their
targeted
delivery.
These
may
effectively
penetrate
blood-brain
barrier
(BBB)
target
multiple
central
nervous
system
(CNS)
diseases
humans.
In
this
review,
we
outline
both
non-canonical
pathways
activation
describe
general
associations
between
activity
CNS
diseases.
Finally,
discuss
prospects
for
delivery
clinical
application
agonists
inhibitors,
highlighting
novel
