Mitochondrial quality control mechanisms as molecular targets in diabetic heart

Metabolism, Journal Year: 2022, Volume and Issue: 137, P. 155313 - 155313

Published: Sept. 17, 2022

Language: Английский

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TMBIM6 prevents VDAC1 multimerization and improves mitochondrial quality control to reduce sepsis-related myocardial injury

Metabolism, Journal Year: 2023, Volume and Issue: 140, P. 155383 - 155383

Published: Jan. 2, 2023

Language: Английский

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Ginsenoside Rb1 ameliorates heart failure through DUSP-1-TMBIM-6-mediated mitochondrial quality control and gut flora interactions

Phytomedicine, Journal Year: 2024, Volume and Issue: 132, P. 155880 - 155880

Published: July 20, 2024

Language: Английский

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Traditional Chinese medicine and mitophagy: A novel approach for cardiovascular disease management

Phytomedicine, Journal Year: 2024, Volume and Issue: 128, P. 155472 - 155472

Published: Feb. 24, 2024

Language: Английский

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The oral-gut microbiota axis: a link in cardiometabolic diseases

npj Biofilms and Microbiomes, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 10, 2025

Language: Английский

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ß-tubulin contributes to Tongyang Huoxue decoction-induced protection against hypoxia/reoxygenation-induced injury of sinoatrial node cells through SIRT1-mediated regulation of mitochondrial quality surveillance

Phytomedicine, Journal Year: 2022, Volume and Issue: 108, P. 154502 - 154502

Published: Oct. 13, 2022

Language: Английский

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Zishenhuoxue decoction-induced myocardial protection against ischemic injury through TMBIM6-VDAC1-mediated regulation of calcium homeostasis and mitochondrial quality surveillance

Phytomedicine, Journal Year: 2023, Volume and Issue: 132, P. 155331 - 155331

Published: Dec. 31, 2023

Language: Английский

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Mitochondrial disorder and treatment of ischemic cardiomyopathy: Potential and advantages of Chinese herbal medicine

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 159, P. 114171 - 114171

Published: Jan. 13, 2023

Mitochondrial dysfunction is the main cause of damage to pathological mechanism ischemic cardiomyopathy. In addition, mitochondrial can also affect homeostasis cardiomyocytes or endothelial cell dysfunction, leading a vicious cycle oxidative stress. And an important basis for cardiomyopathy and reperfusion injury after myocardial infarction end-stage coronary heart disease. Therefore, mitochondria be used as therapeutic targets against ischemia injury, regulation morphology, function structure key way targeting quality control mechanisms. includes mechanisms such mitophagy, dynamics (mitochondrial fusion/fission), biosynthesis, unfolded protein responses. Among them, increase fragmentation caused by fission initial factor. The protective fusion strengthen interaction synthesis paired promote biosynthesis. hypoxia, formation fragments, fragmented lead damaged DNA production, which biosynthesis insufficient ATP ROS. Burst growth loss membrane potential. This eventually leads accumulation mitochondria. Then, under leadership complete degradation process through transport morphologically structurally lysosomes degradation. But once increases, may activate pathway cardiomyocyte death. Although laboratory studies have found that variety mitochondrial-targeted drugs reduce protect cardiomyocytes, there are still few successfully passed clinical trials. this review, we describe role MQS in ischemia/hypoxia-induced physiopathology elucidate relevant further explained advantages natural products improving protecting cells from perspective pharmacological mechanism, its related Potential targeted therapies improve ischemia/hypoxia discussed, aiming accelerate development cardioprotective dysfunction.

Language: Английский

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Kynurenines, Neuronal Excitotoxicity, and Mitochondrial Oxidative Stress: Role of the Intestinal Flora

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1698 - 1698

Published: Jan. 30, 2024

The intestinal flora has been the focus of numerous investigations recently, with inquiries not just into gastrointestinal aspects but also pathomechanism other diseases such as nervous system disorders and mitochondrial diseases. Mitochondrial are most common type inheritable metabolic illness caused by mutations nuclear DNA. Despite intensive research, its diagnosis is usually difficult, unfortunately, treating it challenges physicians. Metabolites kynurenine pathway linked to many disorders, depression, schizophrenia, migraine, associated impaired function. includes substances, for instance kynurenic acid quinolinic acid. In this review, we would like show a possible link between metabolites stress in context flora. Furthermore, summarize markers future therapeutic options excitotoxicity oxidative stress.

Language: Английский

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Co-decoction of Lilii bulbus and Radix Rehmannia Recens and its key bioactive ingredient verbascoside inhibit neuroinflammation and intestinal permeability associated with chronic stress-induced depression via the gut microbiota-brain axis

Phytomedicine, Journal Year: 2024, Volume and Issue: 129, P. 155510 - 155510

Published: March 11, 2024

Language: Английский

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