Frontiers in Immunology,
Journal Year:
2022,
Volume and Issue:
13
Published: Dec. 15, 2022
Nonalcoholic
steatohepatitis
(NASH)
is
the
progressive
form
of
nonalcoholic
fatty
liver
disease
(NAFLD),
and
dysregulation
lipid
metabolism
oxidative
stress
are
typical
features.
Subsequent
dyslipidemia
oxygen
radical
production
may
render
formation
modified
lipids.
Macrophage
scavenger
receptor
1
(MSR1)
responsible
for
uptake
lipoprotein
one
key
molecules
in
atherosclerosis.
However,
unrestricted
lipoproteins
by
MSR1
cholesterol-rich
foamy
macrophages
also
can
be
observed
NASH
patients
mouse
models.
In
this
review,
we
highlight
NASH,
alteration
expression
physiological
pathological
conditions,
lipoproteins,
role
on
macrophage
foaming
development
progression.
Life,
Journal Year:
2024,
Volume and Issue:
14(10), P. 1283 - 1283
Published: Oct. 10, 2024
High-fat
diets
have
detrimental
health
impacts
that
increase
the
likelihood
of
developing
obesity
and
metabolic
syndrome.
This
study
aimed
to
examine
potential
antioxidant
anti-inflammatory
effects
orlistat
white
tea
in
rats
fed
a
high-fat
diet.
Thirty-two
were
randomized
into
four
groups:
control
(standard
diet),
HFD
(high-fat
HFD+Orlistat
diet+orlistat),
HFD+WT
diet+white
extract).
A
significant
malondialdehyde
(MDA)
levels
decrease
total
thiol
(TT)
detected
group
(
Phytotherapy Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 30, 2024
ABSTRACT
Metabolic
dysfunction‐associated
fatty
liver
disease
(MAFLD)
and
diabesity
(diabetes
related
to
obesity)
are
interrelated
since
glucose
lipid
alterations
play
a
vital
role
in
the
development
of
both
disorders.
Due
their
multi‐variant
metabolic
features,
more
than
one
drug
or
natural
product
may
be
required
achieve
proper
therapeutic
effects.
This
study
aimed
evaluate
effectiveness
formulation
containing
co‐micronized
palmitoylethanolamide
rutin
(PEA‐Rut)
associated
with
hydroxytyrosol
(HT),
namely
NORM3,
against
hepatic
damage
high‐fat
diet
(HFD)‐induced
mice.
NORM3
decreased
body
weight
fat
mass
obese
The
improved
HFD‐altered
insulin
sensitivity
production
metabolism,
as
shown
by
glucose,
insulin,
pyruvate
tolerance
tests,
Western
blot,
real‐time
PCR.
In
liver,
limited
macro‐
micro‐vacuolar
steatosis,
revealed
morphological
analysis,
reduced
inflammation.
counteracted
dysfunctions
HFD
animals,
activating
AMPK,
key
cellular
energy
sensor,
normalizing
expression
carnitine
palmitoyl‐transferase
(CPT)1,
rate‐limiting
enzyme
acid
β‐oxidation,
other
genes
involved
homeostasis.
Relevantly,
antioxidant
activity
was
proved
(reduced
ROS
increased
detoxifying
factors
enzymes).
Finally,
vitro
synergistic
protective
effects
components
(PEA‐Rut
HT)
on
H
2
O
‐induced
oxidative
challenge
HepG2
were
determined
(ROS
production,
inflammation,
defense).
Our
results
show
beneficial
effect
its
potential
an
innovative
phytotherapeutic
combination
limiting
progression
counteracting
dysmetabolism
diabesity.
Bioimpacts,
Journal Year:
2023,
Volume and Issue:
13(4), P. 301 - 311
Published: May 30, 2023
Silymarin
proved
to
be
a
beneficial
herbal
medicine
against
many
hepatic
disorders
such
as
alcoholic
liver
disease
(ALD).
However,
its
application
is
restricted
due
low
bioavailability
and
consequently
decreased
efficacy.
We
herein
used
nano-based
approach
known
"phytosome",
improve
silymarin
increase
efficacy.Phytosome
nanoparticles
(NPs)
were
synthesized
using
thin
film
hydration
method.
NPs
size,
electrical
charge,
morphology,
stability,
molecular
interaction,
entrapment
efficiency
(EE
%)
loading
capacity
(LC
determined.
Moreover,
in
vitro
toxicity
of
was
investigated
on
mesenchymal
stem
cells
(MSCs)
viability
MTT
assay.
In
vivo
experiments
performed
24
adult
rats
that
divided
into
four
groups
including
control,
ethanol
(EtOH)
treatment,
silymarin/EtOH
treatment
phytosome/EtOH,
with
6
mice
each
group.
Experimental
given
40%
EtOH,
(50
mg/kg)
phytosome
(200
through
the
gastric
gavage
once
day
for
3
weeks.
Biochemical
parameters,
containing
ALP,
ALT,
AST,
GGT,
GPx
MDA
measured
before
after
experiment
investigate
protective
effect
phytosomal
form.
And
histopathological
examination
done
evaluate
pathological
changes.Silymarin
mean
size
100
nm
produced
well
tolerated
cell
culture.
These
showed
considerable
ALD
inverting
biochemical
parameters
(ALP,
GPx)
alterations.Silymarin
can
an
efficient
ALD.
Frontiers in Immunology,
Journal Year:
2022,
Volume and Issue:
13
Published: Dec. 15, 2022
Nonalcoholic
steatohepatitis
(NASH)
is
the
progressive
form
of
nonalcoholic
fatty
liver
disease
(NAFLD),
and
dysregulation
lipid
metabolism
oxidative
stress
are
typical
features.
Subsequent
dyslipidemia
oxygen
radical
production
may
render
formation
modified
lipids.
Macrophage
scavenger
receptor
1
(MSR1)
responsible
for
uptake
lipoprotein
one
key
molecules
in
atherosclerosis.
However,
unrestricted
lipoproteins
by
MSR1
cholesterol-rich
foamy
macrophages
also
can
be
observed
NASH
patients
mouse
models.
In
this
review,
we
highlight
NASH,
alteration
expression
physiological
pathological
conditions,
lipoproteins,
role
on
macrophage
foaming
development
progression.
