Lower serum BDNF as a predictor of post-stroke cognitive impairment in acute ischemic stroke patients DOI Creative Commons
Ismail Setyopranoto,

Astuti Prodjohardjono,

Sri Sutarni

et al.

F1000Research, Journal Year: 2024, Volume and Issue: 11, P. 749 - 749

Published: March 8, 2024

Background Reduced level of serum brain-derived neurotrophic factor (BDNF) in acute stroke patients is associated with poor outcomes. We aimed to identify the role BDNF as a predictor for post-stroke cognitive impairment (PSCI). Methods This was prospective study. recruited ischemic Dr. Sardjito General Hospital Yogyakarta, Indonesia followed them up 90 days (3 months). Serum collected at day 5 and 30 onset measured by enzyme-linked immunosorbent assay (ELISA). Montreal Cognitive Assessment (MoCA) used measure function follow up. Receiver operating characteristic (ROC) curve conducted cut-off point level. Factors independently PSCI were analyzed using stepwise regression. Results Among 89 recruited, 60 (67.41%) developed PSCI. The mean age non-PSCI 62.7 ± 9.5 57.5 8.7, respectively (p = 0.01). Patients dyslipidemia less likely develop (OR 0.10, 95%CI 0.02-0.51, p < 0.05). In addition, 5-serum 23.29 ng/mL five times more compared their counterparts 5.15, 1.26-21.09, Conclusions patients, those <23.29 had higher risk developing study suggests that could be PSCI, allowing earlier detection better preventive strategies.

Language: Английский

Supplementation with a Symbiotic Induced Neuroprotection and Improved Memory in Rats with Ischemic Stroke DOI Creative Commons
Yolanda Cruz,

Leslie Aguilar-Ponce,

Alejandra Romo‐Araiza

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(1), P. 209 - 209

Published: Jan. 17, 2024

After an ischemic stroke, various harmful mechanisms contribute to tissue damage, including the inflammatory response. The increase in pro-inflammatory cytokines has been related greater damage neural and promotion of neurological alterations, cognitive impairment. Recent research shown that use prebiotics and/or probiotics counteracts inflammation improves function through production growth factors, such as brain-derived neurotrophic factor (BDNF), by reducing molecules. Therefore, this study, effect symbiotic inulin

Language: Английский

Citations

7
Lower serum BDNF as a predictor of post-stroke cognitive impairment in acute ischemic stroke patients DOI Creative Commons
Ismail Setyopranoto,

Astuti Prodjohardjono,

Sri Sutarni

et al.

F1000Research, Journal Year: 2024, Volume and Issue: 11, P. 749 - 749

Published: March 8, 2024

Background Reduced level of serum brain-derived neurotrophic factor (BDNF) in acute stroke patients is associated with poor outcomes. We aimed to identify the role BDNF as a predictor for post-stroke cognitive impairment (PSCI). Methods This was prospective study. recruited ischemic Dr. Sardjito General Hospital Yogyakarta, Indonesia followed them up 90 days (3 months). Serum collected at day 5 and 30 onset measured by enzyme-linked immunosorbent assay (ELISA). Montreal Cognitive Assessment (MoCA) used measure function follow up. Receiver operating characteristic (ROC) curve conducted cut-off point level. Factors independently PSCI were analyzed using stepwise regression. Results Among 89 recruited, 60 (67.41%) developed PSCI. The mean age non-PSCI 62.7 ± 9.5 57.5 8.7, respectively (p = 0.01). Patients dyslipidemia less likely develop (OR 0.10, 95%CI 0.02-0.51, p < 0.05). In addition, 5-serum 23.29 ng/mL five times more compared their counterparts 5.15, 1.26-21.09, Conclusions patients, those <23.29 had higher risk developing study suggests that could be PSCI, allowing earlier detection better preventive strategies.

Language: Английский

Citations

0