Asian Journal of Surgery, Journal Year: 2023, Volume and Issue: 47(3), P. 1585 - 1586
Published: Dec. 15, 2023
Language: Английский
Journal of Stomatology Oral and Maxillofacial Surgery, Journal Year: 2024, Volume and Issue: unknown, P. 102143 - 102143
Published: Nov. 1, 2024
Language: Английский
Citations
1
Cancers, Journal Year: 2024, Volume and Issue: 16(22), P. 3843 - 3843
Published: Nov. 15, 2024
SGCs are rare malignancies, accounting for less than 1% of all head and neck cancers [...].
Language: Английский
Citations
1
Cells, Journal Year: 2023, Volume and Issue: 12(20), P. 2437 - 2437
Published: Oct. 11, 2023
Salivary gland tumors (SGTs) are rare and complex neoplasms characterized by heterogenous histology clinical behavior as well resistance to systemic therapy. Tumor etiology is currently under elucidation an interplay of genetic epigenetic changes has been proposed contribute tumor development. In this work, we investigated regulators histone-modifying factors that may alter gene expression participate in the pathogenesis SGT neoplasms. We performed a detailed bioinformatic analysis on publicly available RNA-seq dataset 94 ACC tissues supplemented with data respective controls generated protein-protein interaction (PPI) network chromatin histone modification factors. A significant upregulation TP53 enzymes SUV39H1, EZH2, PRMT1, HDAC8, KDM5B, along DNA methyltransferase DNMT3A ubiquitin ligase UHRF1 mRNA levels, downregulation lysine acetyltransferase KAT2B were detected tissues. The protein p53, HDAC8 was further validated their functional deposition repressive marks H3K9me3 H3K27me3, respectively. Overall, study first detect interacting proteins affecting structure modifications salivary cells, providing mechanistic insights molecular profile SGTs confer altered programs.
Language: Английский
Citations
2
Cureus, Journal Year: 2024, Volume and Issue: unknown
Published: Feb. 22, 2024
Background Adenoid cystic carcinoma (ACC) poses clinical challenges with its unique histology and potential for perineural invasion, recurrence, distant metastases. Recent genomic advancements have unveiled key genetic alterations in ACC, offering insights into pathogenesis. Aim This study aims to unravel the intricate molecular landscape of ACC through a comprehensive analysis gene expression patterns. By integrating data from multiple microarray datasets, explores differentially expressed genes (DEGs), their functional enrichment, protein-protein interactions (PPI), hub genes, microRNA (miRNA) involvement, transcription factors, drug-gene interactions. Methods Three datasets (GSE88804, GSE153002, GSE36820) related were selected Gene Expression Omnibus (GEO) repository. DEGs identified using GEO2R further analyzed commonalities differences. Functional enrichment analysis, including Set Enrichment Analysis (GSEA), provided biological processes, cellular components, functions, Kyoto Encyclopedia Genes Genomes (KEGG) pathways associated ACC. PPI networks Search Tool Retrieval Interacting Genes/Proteins (STRING) (STRING Consortium, Lausanne, Switzerland) database Cytoscape (Cytoscape California, United States). The also explored miRNAs, Results integrated revealed 339 common upregulated 643 downregulated pathway analyses involvement these critical signaling cascades, pathways. network, comprising 904 nodes 4139 edges, highlighted complexity Hub KIF11, BUB1, DLGAP5, identified, shedding light on pivotal roles cell cycle regulation. miRNAs (e.g., hsa-mir-7-5p hsa-mir-138-5p) factors E2F1 TP53) Drug-gene therapeutic options, amsacrine rucaparib. Conclusions highlights nuanced landscape, identifying such as KIF11 CDK1 targets given progression. dysregulation microRNAs adds ACC's profile. Exploration reveals promising strategies, involving FDA-approved drugs rucaparib, providing avenues personalized interventions.
Language: Английский
Citations
0
Radiology Case Reports, Journal Year: 2024, Volume and Issue: 19(8), P. 3049 - 3055
Published: May 7, 2024
Salivary duct carcinoma (SDC) is a major malignant salivary gland tumor that usually forms solid tumor. Non-necrotic macrocystic SDCs have rarely been reported among tumors. A 78-year-old Japanese man with submandibular was evaluated radiologically, pathologically, and immunohistochemically. multilocular lesion maximum size of 6 cm radiologically observed in the left region. It had noticed 20 years earlier. Malignant cytological result obtained, surgical resection performed. Pathological examination revealed non-necrotic, lined glandular, cribriform, or papillary atypical cuboidal cells. Frankly invasive components were intercystic areas. Intraductal, mucoepidermoid, secretory carcinomas identified as pathological differential diagnoses because their morphology. We diagnosed SDC there no intraductal growth based on lack myoepithelial markers, diffuse immunoreactivity to gross cystic disease fluid protein15, androgen receptor, mammaglobin immunonegativity S100 p63. Postoperative positron emission tomography absence lymph node distant metastases. The patient disease-free 9 months after surgery. can be included
Language: Английский
Citations
0
Mayo Clinic Proceedings, Journal Year: 2024, Volume and Issue: 99(6), P. 1017 - 1018
Published: June 1, 2024
Citations
0
Head and Neck Pathology, Journal Year: 2024, Volume and Issue: 18(1)
Published: June 19, 2024
Language: Английский
Citations
0
Cureus, Journal Year: 2024, Volume and Issue: unknown
Published: June 27, 2024
Adenoid cystic carcinoma (ACC) is an uncommon and aggressive head neck cancer mainly affecting minor salivary glands. It affects more women than men in their 60s 70s. The tumor typically locally has a high rate of distant metastatic disease. This report unveils potential avenue for targeted therapy the management disease: patient with ACC who harbored specific fibroblast growth factor receptor 2 (FGFR-2) mutation responded significantly to novel FGFR-2 inhibitor. finding could pave way personalized treatment options patients similar genetic alterations. Nevertheless, use futibatinib requires further investigation optimize protocols, including exploring combination therapies, identifying predictive biomarkers response, developing strategies overcome resistance.
Language: Английский
Citations
0
Balkan Journal of Dental Medicine, Journal Year: 2024, Volume and Issue: 28(2), P. 143 - 149
Published: Jan. 1, 2024
Background/Aim: Adenoid cystic carcinoma (ACC) is a rare type of cancer that most often occurs in the salivary glands. The aim this report was to describe very case ACC floor mouth referring usefulness combined imaging methodology for detection exact origin and extension tumor. Case Report: A 70-year-old female patient referred private practice one authors (D.A., Thessaloniki, Greece). Before examination, provided written informed consent accordance with Helsinki Declaration research patient's ethics. Subsequently, examined thoroughly. She exhibited swelling on (left side). painless, firm-solid upon palpation, non-movable attached adjacent tissues normal covering oral mucosa. an ultrasonography MRI examination afterwards incisional biopsy performed. surgical removal involved sublingual but also submandibular (for safety reasons) glands were performed under general nasopharyngeal anesthesia bilateral, both external intraoral access. In addition, post-surgical radiotherapy Conclusions: Due aggressiveness lesion fact cases are affected, surgeons tend be rather aggressive their interventions. techniques may vary interpretation lesions. Ultrasonography examinations assist surgeon by depicting borders investigation, much more accurately, supporting establishment diagnosis avoiding unnecessary loss healthy neighboring tissue.
Language: Английский
Citations
0
Cureus, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 6, 2024
HPV-related multiphenotypic sinonasal carcinoma (HMSC) is a rare malignancy of the nasal cavity or paranasal sinuses that often presents with indolent behavior despite aggressive histologic appearance. Herein, we present an unusual case patient HMSC presenting rapid local recurrence, highlighting histopathology and diagnostic therapeutic strategies surrounding HMSC.
Language: Английский
Citations
0