Bioactivity and Bioavailability of Carotenoids Applied in Human Health: Technological Advances and Innovation

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7603 - 7603

Published: July 11, 2024

This article presents a groundbreaking perspective on carotenoids, focusing their innovative applications and transformative potential in human health medicine. Research jointly delves deeper into the bioactivity bioavailability of revealing therapeutic uses technological advances that have to revolutionize medical treatments. We explore pioneering which carotenoids are used treat chronic diseases such as cancer, cardiovascular disease, age-related macular degeneration, offering novel protective mechanisms benefits. Our study also shows cutting-edge innovations carotenoid extraction bioavailability, including development supramolecular carriers advanced nanotechnology, dramatically improve absorption efficacy these compounds. These not only ensure consistent quality but tailor therapies each patient's needs, paving way for personalized By integrating latest scientific discoveries techniques, this research provides prospective clinical establishing new benchmark future studies field. findings underscore importance optimizing extraction, administration, bioactivity, methods develop more effective, targeted, treatments, thus visionary insight modern practices.

Language: Английский

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Ferritin‐Based Supramolecular Assembly Drug Delivery System for Aminated Fullerene Derivatives to Enhance Tumor‐Targeted Therapy

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 31, 2024

Owing to their attractive antitumor effects, aminated fullerene derivatives are emerging as promising therapeutic drugs for cancer. However, in vivo applications severely limited due cation toxicity. To address this problem, human heavy chain ferritin (HFn), possessing natural biocompatibility is utilized, develop a novel supramolecular assembly drug delivery system. Specifically, tetra[4-(amino)piperidin-1-yl]-C

Language: Английский

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STAT3 Signaling Pathway in Health and Disease

MedComm, Journal Year: 2025, Volume and Issue: 6(4)

Published: March 30, 2025

ABSTRACT Signal transducer and activator of transcription 3 (STAT3) is a critical factor involved in multiple physiological pathological processes. While STAT3 plays an essential role homeostasis, its persistent activation has been implicated the pathogenesis various diseases, particularly cancer, bone‐related autoimmune disorders, inflammatory cardiovascular neurodegenerative conditions. The interleukin‐6/Janus kinase (JAK)/STAT3 signaling axis central to activation, influencing tumor microenvironment remodeling, angiogenesis, immune evasion, therapy resistance. Despite extensive research, precise mechanisms underlying dysregulated disease progression remain incompletely understood, no United States Food Drug Administration (USFDA)‐approved direct inhibitors currently exist. This review provides comprehensive evaluation STAT3's health disease, emphasizing involvement cancer stem cell maintenance, metastasis, inflammation, drug We systematically discuss therapeutic strategies, including JAK (tofacitinib, ruxolitinib), Src Homology 2 domain (S3I‐201, STATTIC), antisense oligonucleotides (AZD9150), nanomedicine‐based delivery systems, which enhance specificity bioavailability while reducing toxicity. By integrating molecular mechanisms, pathology, emerging interventions, this fills knowledge gap STAT3‐targeted therapy. Our insights into crosstalk, epigenetic regulation, resistance offer foundation for developing next‐generation with greater clinical efficacy translational potential.

Language: Английский

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pH‐responsive supramolecular vesicles composed of sulfobutylether‐β‐cyclodextrin and N‐dodecyl chitosan for controlled release of naproxen sodium

Polymer Engineering and Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Abstract pH‐responsive supramolecular polymeric vesicles were successfully developed through the host–guest complexation of two biocompatible and water‐soluble saccharides: sulfobutylether‐β‐cyclodextrin (SCD) N ‐dodecyl chitosan (DCS). Extensive characterization using UV–vis spectroscopy, dynamic light scattering (DLS), zeta potential measurements, transmission electron microscopy (TEM) confirmed structural robustness vesicles, which exhibited effective self‐assembly in acidic conditions disassembly alkaline environments. To evaluate drug‐loading capacity release properties, naproxen sodium (NS), a widely used nonsteroidal anti‐inflammatory drug, was encapsulated as model compound. In vitro studies simulating gastrointestinal pH (2.0, 6.8, 8.5) demonstrated minimal drug (28.34 ± 1.02)% at low significantly enhanced (56.57 1.68)% (86.96 1.29)% neutral slightly pH, respectively. The system an initial burst followed by sustained release, aligning with therapeutic requirements for rapid onset prolonged action. These findings highlight SCD/DCS versatile platform targeted oral delivery, particularly drugs requiring intestinal release. Highlights Supramolecular self‐assembled via (DCS) complexation. Vesicles stability disassembled conditions. Naproxen sodium‐loaded displayed pH‐sensitive properties. Drug occurred to ideal delivery.

Language: Английский

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Supramolecular approach to the design of nanocarriers for antidiabetic drugs: targeted patient-friendly therapy

Russian Chemical Reviews, Journal Year: 2024, Volume and Issue: 93(11), P. RCR5150 - RCR5150

Published: Oct. 30, 2024

Diabetes and its complications derived are among serious global health concerns that critically deteriorate the quality of life patients and, in some cases, result lethal outcome. Herein, general information on pathogenesis, factors aggravating course disease drugs used for treatment two types diabetes briefly discussed. The aim review is to introduce supramolecular strategies currently being developed mellitus present a very effective alternative chemical synthesis, allowing fabrication nanocontainers with switchable characteristics meet criteria green chemistry. Particular attention paid organic (amphiphilic polymeric) formulations, including those natural origin, due their biocompatibility, low toxicity, bioavailability. advantages limitations different nanosystems discussed, emphasis adaptivity noninvasive administration routes.<br>The bibliography includes 378 references.

Language: Английский

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Shielding siRNA by peptide-based nanofibers: An efficient approach for turning off EGFR gene in breast cancer

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 292, P. 139219 - 139219

Published: Dec. 27, 2024

Language: Английский

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