A cost-effective, machine learning-driven approach for screening arterial functional aging in a large-scale Chinese population

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: March 20, 2024

Introduction An easily accessible and cost-free machine learning model based on prior probabilities of vascular aging enables an application to pinpoint high-risk populations before physical checks optimize healthcare investment. Methods A dataset containing questionnaire responses measurement parameters from 77,134 adults was extracted the electronic records Health Management Center at Third Xiangya Hospital. The least absolute shrinkage selection operator recursive feature elimination-Lightweight Gradient Elevator were employed select features a pool potential covariates. participants randomly divided into training (70%) test cohorts (30%). Four algorithms applied build screening models for elevated arterial stiffness (EAS), performance evaluated by calculating area under receiver operating characteristic curve (AUC), sensitivity, specificity, accuracy. Results Fourteen selected construct model, including “systolic blood pressure” (SBP), “age,” “waist circumference,” “history hypertension,” “sex,” “exercise,” “awareness normal pressure,” “eat fruit,” “work intensity,” “drink milk,” bean products,” “smoking,” “alcohol consumption,” “Irritableness.” extreme gradient boosting (XGBoost) outperformed other three models, achieving AUC values 0.8722 0.8710 in sets, respectively. most important five are SBP, age, waist, history hypertension, sex. Conclusion XGBoost ideally assesses probability current EAS general population. integration primary care facilities has lower medical expenses enhance management aging.

Language: Английский

The Role of ROS in Electronic Cigarette- and Heated Tobacco Product-Induced Damage

Oxygen, Journal Year: 2024, Volume and Issue: 4(4), P. 363 - 376

Published: Sept. 25, 2024

The success of heated tobacco products (HTPs) and electronic cigarettes (e-cigs) has been largely attributed to their ability mimic the gestural experience traditional cigarette smoking, while being perceived as a safer alternative due absence combustion, well appeal, particularly among younger populations. Despite initial idea that these new devices were harmless, recent literature reveals concerning expanding body evidence on potential toxicity. Thus, this review aims elucidate mechanisms by which reactive oxygen species generated HTPs e-cigs induce oxidative stress inflammation subsequent biological health consequences, in order raise awareness significance addressing toxicological effects associated with devices, are commonly believed be safe.

Language: Английский

Intermittent Exercise and Cigarette Smoke Extract-Induced Pulmonary Tensegrity Dysfunction; Monitoring Elastin, Matrix Metalloproteinase-12, Transforming Growth Factor-beta 1

Zahedan Journal of Research in Medical Sciences, Journal Year: 2024, Volume and Issue: 26(4)

Published: Oct. 22, 2024

Background: Cigarette smoke causes inflammation of the alveoli, leading to airflow restriction and potentially irreversible changes in lung architecture, including pulmonary emphysema. This study investigates effects a six-week aerobic interval training regimen on elastin activity rat model cigarette smoke-induced COPD (CS-COPD). Objectives: Specifically, we observe variables matrix metalloproteinase-12 (MMP12) transforming growth factor-beta (TGF-β1). Methods: Twenty male Wistar rats, aged eight weeks, were divided into four groups (n = 5 per group): Control, (Exe), extract (CSE), CSE + Exe. The (Exe) was performed for 49 min/day, five days week six weeks form. group received an intraperitoneal (IP) injection 150 µL CSE, one day weeks. Results: Exe showed significant decrease gene expression tissue compared healthy control (P 0.0002 P 0.0057, respectively) 0.0042, respectively). Additionally, exhibited increase MMP12 0.0008 0.0013, Notably, 0.0015). Furthermore, demonstrated TGFB1 < 0.0001 0.0022, both). Conclusions: Our findings indicate that exposed experienced levels, accompanied by TGF-β1 expression. Although provided some protection against detrimental exposure, it not sufficient fully reverse harmful impacts disease.

Language: Английский