Advancements in Drug Delivery Systems for the Treatment of Sarcopenia: An Updated Overview DOI Open Access
Alfred Najm,

Elena-Theodora Moldoveanu,

Adelina-Gabriela Niculescu

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10766 - 10766

Published: Oct. 7, 2024

Since sarcopenia is a progressive condition that leads to decreased muscle mass and function, especially in elderly people, it public health problem requires attention from researchers. This review aims highlight drug delivery systems have high efficient therapeutic potential for sarcopenia. Current as well future research needs consider the barriers encountered realization of systems, such route administration, interaction with aggressive environment human body, loading agents, targeted agents into tissue without creating undesirable adverse effects. Thus, this paper sets framework existing possibilities treatment sarcopenia, serving an inception point interdisciplinary studies.

Language: Английский

Peptides: Emerging Candidates for the Prevention and Treatment of Skin Senescence: A Review DOI Creative Commons

Andrada Pintea,

Andrei Manea,

Cezara Pintea

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(1), P. 88 - 88

Published: Jan. 9, 2025

One class of cosmetic compounds that have raised interest many experts is peptides. The search for ingredients with good biocompatibility and bioactivity has led to the use peptides in products. Peptides are novel active improve collagen synthesis, enhance skin cell proliferation, or decrease inflammation. Based on their mechanism action, they can be classified into signal peptides, carrier neurotransmitter inhibitor enzyme This review focuses main types application field, underlining limitations. most significant drawbacks poor permeability through membranes, which limits delivery effectiveness. As a result, this follows methods used improving stratum corneum. Increasing peptide bioavailability stability enhanced desired site action visible effects become central points latest research due promising features. For purpose, several been identified described. Physical techniques include thermal ablation (radiofrequency laser), electrical (electroporation, iontophoresis), mechanical approach (microneedles), ultrasounds. an alternative, innovative formulations developed nano-systems such as liposomes, niosomes, ethosomes, nanoemulsions, other nanomaterials reduce irritation product purpose provide information regarding these noteworthy molecules reasoning behind formulations.

Language: Английский

Citations

2
Harnessing Ultrasonic Technologies to Treat Staphylococcus Aureus Skin Infections DOI Creative Commons
John Hulme

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 512 - 512

Published: Jan. 23, 2025

The rise of antibiotic-resistant Staphylococcus aureus strains, particularly MRSA, complicates the management skin and soft tissue infections. This review highlights ultrasonic methodologies as adjunctive therapies to combat S. aureus-driven infections prevent progression biofilm formation chronic wounds. Low- high-frequency ultrasound (LFU HFU) demonstrate potential in disrupting biofilms, enhancing drug delivery, promoting repair through cavitation microbubble activity. These approaches integrate frequencies with microbubbles therapeutics, such antibiotics affimers, minimize resistance improve healing. Tailoring bioeffects on structures localized delivery technologies, including microneedle patches piezoelectric systems, presents promising solutions for early intervention structure (SSSIs).

Language: Английский

Citations

0
Novel strategies in topical delivery for psoriasis treatment: nanocarriers and energy-driven approaches DOI
Cheng-Yu Lin, Zih‐Chan Lin,

Yen-Tzu Chang

et al.

Expert Opinion on Drug Delivery, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Psoriasis is characterized by abnormal differentiation and hyperproliferation of epidermal keratinocytes. This condition presents significant challenges for effective drug delivery. In addition to overcoming the thickness skin, topical treatments must navigate complex hydrophobic hydrophilic properties skin barrier. Recent advancements in nanocarrier technologies, including energy-driven methods microneedles that penetrate stratum corneum, present promising strategies enhancing permeation through tailored physicochemical properties. A literature search was performed using databases Google Scholar, PubMed, ScienceDirect. review highlights recent studies on novel delivery psoriasis treatment, addressing current therapeutic options their limitations. We provide a comprehensive overview chemical nanoformulations explore physical improve rates. Furthermore, we discuss advantages various formulations can carry different types payloads, offering patients diverse symptom management. The covers conventional treatments, emphasizing nanoparticle design macromolecular drugs. includes Ribonucleic acid (RNA)-based therapies protect drugs from rapid clearance body. argue intelligent approaches enhance efficacy across applications while allowing precision treatment strategies, ultimately improving patient outcomes.

Language: Английский

Citations

0
Non-porous silica nanoparticles as a cavitation sensitive vehicle for antibiotic delivery DOI Creative Commons

G. T. Ball,

Jack Stevenson,

Faraz Amini Boroujeni

et al.

Ultrasonics Sonochemistry, Journal Year: 2025, Volume and Issue: 116, P. 107316 - 107316

Published: March 17, 2025

Language: Английский

Citations

0
Development of a dual-frequency sonophoresis for enhanced skin permeability and efficient drug delivery DOI
Abdulkhaliq Alsaadi, Farhang Honarvar, Mohammad Akrami

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125539 - 125539

Published: March 1, 2025

Language: Английский

Citations

0
Bioinspired Suction-Driven Strategies with Nanoscale Skin-Controllable Adhesive Architectures for Efficient Liquid Formulated Transdermal Patches DOI

Dohyun Lim,

Minwoo Song,

Minjin Kim

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

For highly efficient and precise drug release, transdermal delivery systems (TDDS) have recently evolved through the combination of intelligent material-based structures with various active components. These strategies are an effort to overcome significant difficulties in delivering large molecule drugs nanomaterials due physical barrier skin, especially stratum corneum, traditional TDDS. Interestingly, multiscale suction-driven architectures (SDAs) inspired by bioinspired suction adhesion mechanisms provided innovative solutions these challenges. employ negative pressure enhance nanoscale skin-controllable skin adhesion, temporarily bypass barrier, facilitate deep penetration therapeutic agents, thereby, achieving goals increasing efficiency maximizing user convenience as a minimal invasive, needle-free platform. This review provides comprehensive overview patches emphasizes their integration multifunctional materials achieve stable controlled release. Next, we present cost-effective user-friendly patch devices optimization cupping without incorporation additional devices. Furthermore, that optimize need for Potential SDAs localized systemic challenging complex well future perspectives, discussed, along directions more patient-centric solutions.

Language: Английский

Citations

0
Nanobiohybrid Oncolytic Bacteria with Optimized Intratumoral Distribution for Combined Sono–Photodynamic/Immunotherapy DOI
Xu Zhang,

Zhongsheng Zang,

Zhenguo Liang

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

"Living therapeutic carriers" present a promising avenue for cancer research, but it is still challenging to achieve uniform and durable distribution of payloads throughout the solid tumor owing microenvironment heterogeneity. Herein, living drug sprinkle biohybrid (YB1–HCNs) was constructed by hitching acid/enzyme-triggered detachable nanoparticles (HCNs) backpack on surface metabolic oligosaccharide-engineered oncolytic bacteria YB1. Along with process penetration bacterial hypoxia navigation, YB1–HCNs responsively continuously release HCNs, achieving loaded agents tumor. Upon successive irradiation laser ultrasound (US), HCNs can separately generate type II I ROS superior sono–photodynamic therapy (SPDT), which enables synergize YB1 satisfactory effect in both superficial normoxic deep hypoxic regions After single dose, this efficient combination realized 98.3% primary inhibition rate prolonged survival mice 90 days no recurrence, further inducing powerful immunological memory completely suppress rechallenge cured mice. Such hybridization vector optimization spatial providing an innovative strategy maximize outcomes evoke antitumor immunity.

Language: Английский

Citations

0
Advancing frontiers in skin offensive odor management: from innovative diagnostics to cutting-edge treatments and emerging technologies DOI
Majeed M. A. Ali

Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)

Published: March 8, 2025

Language: Английский

Citations

0
Advancements in Drug Delivery Systems for the Treatment of Sarcopenia: An Updated Overview DOI Open Access
Alfred Najm,

Elena-Theodora Moldoveanu,

Adelina-Gabriela Niculescu

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10766 - 10766

Published: Oct. 7, 2024

Since sarcopenia is a progressive condition that leads to decreased muscle mass and function, especially in elderly people, it public health problem requires attention from researchers. This review aims highlight drug delivery systems have high efficient therapeutic potential for sarcopenia. Current as well future research needs consider the barriers encountered realization of systems, such route administration, interaction with aggressive environment human body, loading agents, targeted agents into tissue without creating undesirable adverse effects. Thus, this paper sets framework existing possibilities treatment sarcopenia, serving an inception point interdisciplinary studies.

Language: Английский

Citations

1