The efficacy of Lacticaseibacillus paracasei MSMC39-1 and Bifidobacterium animalis TA-1 probiotics in modulating gut microbiota and reducing the risk of the characteristics of metabolic syndrome: A randomized, double-blinded, placebo-controlled study

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(1), P. e0317202 - e0317202

Published: Jan. 10, 2025

Modern treatment, a healthy diet, and physical activity routines lower the risk factors for metabolic syndrome; however, this condition is associated with all-cause cardiovascular mortality worldwide. This investigation involved randomized controlled trial, double-blind, parallel study. Fifty-eight participants of syndrome according to inclusion criteria were into two groups given probiotics ( Lacticaseibacillus paracasei MSMC39-1 Bifidobacterium animalis TA-1) (n = 31) or placebo 27). The had mean age 42.29 ± 7.39 43.89 7.54 years in groups, respectively. Stool samples, anthropometric data, blood chemistries taken at baseline 12 weeks. primary outcome was achieved by group as their low-density lipoprotein-cholesterol level dramatically lowered compared (the difference 39.97 26.83 mg/dl, p-value <0.001). Moreover, significant reductions body weight, mass index, waist circumference, systolic pressure, total cholesterol observed volunteers treated placebo. In gut microbiome analysis, results showed statistically differences beta diversity post-intervention group. Blautia , Roseburia Collinsella Ruminococcus among microbiomes that more prevalent addition, exhibited increases predicted functional changes ATP-binding cassette (ABC) transporters, well ribonucleic acid transport, biosynthesis unsaturated fatty acids, glycerophospholipid metabolism, pyruvate metabolism. conclusion, research demonstrated L . B TA-1 have efficacy syndrome.

Language: Английский

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Factors Affecting Gut Microbiota and Its Relationship with Cardiovascular Diseases: A Narrative Review

Deleted Journal, Journal Year: 2025, Volume and Issue: 2(1)

Published: Feb. 16, 2025

Context: The estimated population of microorganisms inhabiting the gastrointestinal tract is thought to exceed 1014, with a total weight approximately 2 kg. This accumulation microbiota indicates that number bacterial cells ten times greater than human cells, and gene content exceeds genome by more hundredfold. These are essential for maintaining health, having evolved over millions years. They influence vital processes in life, such as digestion regulation immune system. gut (GM) can be viewed dynamic environmental factor, its composition shaped host genetics, dietary patterns, hygiene practices, lifestyle choices. variability positions it potential therapeutic target cardiovascular disease (CVD) myocardial infarction (MI). Evidence Acquisition: present study review factors affecting intestinal relationship heart diseases. To ensure identification most relevant studies, common databases, including PubMed, Scopus, Web Science, were searched using terms "Gut dysbiosis", "Cardiovascular disease", "Probiotics", "prebiotics". articles abstracts obtained from search then reviewed. Results: Dysbiosis plays significant role onset progression atherosclerosis CVD. Microbiota-derived short-chain fatty acids (SCFAs) crucial development blood pressure. Alterations have been linked dysfunctions lipid metabolism, reduced levels high-density lipoprotein (HDL) plasma patients GM affect efficiency energy extraction sources, thereby impacting likelihood developing obesity through inflammation metabolism. Conclusions:

Language: Английский

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Effects of Dietary Fiber and Acetate on Alcoholic Heart Disease and Intestinal Microbes in Mice

Molecular Nutrition & Food Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

ABSTRACT Alcoholic heart disease (AHD) is a severe cardiovascular condition linked to chronic alcohol consumption. This study investigates the effects of high‐fiber diet and acetate on gut microbiota cardiac function in AHD mouse models. Sixty male C57BL/6 mice were divided into six groups, receiving either control diet, or supplementation alongside treatment. Results revealed that fibrosis failure notably improved diets. Transcriptomic analyses indicated dietary interventions modulated expression genes involved lipid metabolism TGF‐β signaling pathway. Additionally, 16S rRNA sequencing showed altered composition, enhancing abundance beneficial bacteria such as Akkermansia muciniphila , Lactobacillus intestinalis Bacteroides acidifaciens . These microbes exhibited positive correlations with related fat signaling, suggesting potential mechanism for microbiota's role pathology. ROC analysis identified these promising biomarkers detection. Overall, our findings underscore therapeutic fiber modulating improving AHD, highlighting intricate relationship between health management.

Language: Английский

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Mechanisms of microbial-gut-brain axis modulation by electroconvulsive therapy in the treatment of depression

Anesthesiology and Perioperative Science, Journal Year: 2025, Volume and Issue: 3(2)

Published: May 7, 2025

Abstract Purpose The present study aims to evaluate the effects of electroconvulsive therapy (ECT) on depressive behaviors. In addition, we explore mechanisms by which ECT alters composition and functioning gut microbiota through microbiota-gut-brain axis. Methods A depression model in mice was established using chronic unpredictable mild stress. were divided into three groups: control, depression, ECT-treated. Depressive behaviors assessed a series behavioral tests, including monitoring body weight, open field sucrose preference forced swim tests. Histological microcirculatory assessments brain tissues conducted hematoxylin eosin (H&E) staining, Nissl staining immunofluorescence methodology along with laser speckle contrast imaging. inflammatory cytokines Tumor Necrosis Factor- α (TNF- ), Interleukin-6 (IL-6) Interleukin-1 β (IL-1 ) quantified enzyme-linked immunosorbent assay. Metagenomic sequencing employed diversity abundance microbiota. Results significantly improved as evidenced increased weight decreased immobility time H&E indicated substantial reduction inflammation while revealed restoration neuronal morphology following treatment. Furthermore, analysis showed elevated c-Fos expression hippocampal region ( P < 0.05). Assessments demonstrated significant reductions TNF- , IL-6, IL-1 levels group. metagenomic that enhanced diversity, particularly restoring Bacteroides Verrucomicrobia Conclusion exerts its antidepressant modulating enhancing functionality gut-brain

Language: Английский

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