Current Opinion in Biotechnology, Journal Year: 2024, Volume and Issue: 90, P. 103213 - 103213
Published: Oct. 10, 2024
Language: Английский
3 Biotech, Journal Year: 2025, Volume and Issue: 15(3)
Published: Feb. 11, 2025
Language: Английский
Citations
1
Small Structures, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 19, 2025
To effectively address crisis emergence of new virus such as monkeypox, a collective and collaborative effort between scientists, engineers, innovators, artists from all ages, regions, diverse fields is required. This review explores holistic approach to addressing the monkeypox by integrating nanobiosensors, artificial intelligence, visual arts, humanities, social sciences. Traditional diagnostic methods are often limited time, accessibility, accuracy, but advancement point‐of‐care smart nanobiosensors offers promising shift toward rapid, precise, accessible diagnostics. They enhance ability screen, diagnose, monitor infections efficiently, contributing better disease management. Beyond technological innovation, essential role sciences in fostering public engagement, understanding, acceptance tools emphasized. Visual arts can illustrate scientific concepts, making them more relatable, while storytelling through various media reduce stigma promote preventive measures. Social provide insights into cultural attitudes, behaviors, health challenges, ensuring that solutions integrated communities. By combining these disciplines, this presents comprehensive framework for resilient global system aligns with One Health principles, emphasizing interconnectedness human, animal, environmental health.
Language: Английский
Citations
1
Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12
Published: March 5, 2025
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is a prevalent chronic liver condition characterized by lipid accumulation and inflammation, often progressing to severe damage. We aim review the pathophysiology, diagnostics, clinical care of MASLD, highlights advances in proteomic technologies. Recent proteomics technologies have improved identification novel biomarkers therapeutic targets, offering insight into molecular mechanisms underlying MASLD progression. focus on application mass spectrometry-based including single cell proteomics, proteogenomics, extracellular vesicle (EV-omics), exposomics for biomarker discovery, emphasizing potential blood-based panels noninvasive diagnosis personalized medicine. Future research directions are presented develop targeted therapies improve outcomes patients.
Language: Английский
Citations
0
Archiv der Pharmazie, Journal Year: 2025, Volume and Issue: 358(3)
Published: March 1, 2025
Quantitative proteomics, an integral subfield within is pivotal for elucidating complex biological processes. By integrating with other omics data, quantitative proteomics facilitates system-level analysis and significantly advances our understanding of cellular networks disease mechanisms. The ongoing advancements in technology boost its importance by improving analytical accuracy. This review focuses on employing liquid chromatography-mass spectrometry (LC-MS), a cornerstone technique renowned sensitivity, selectivity, accuracy, throughput. efficacy LC-MS heavily reliant sample preparation, which encompasses protein extraction, total estimation, reduction, alkylation, digestion, cleanup. For the very first time, this article provides detailed examination preparation methods offering insights guidelines that researchers can utilize to refine their experimental protocols were not critically evaluated before. optimizing workflows, enhance robustness reproducibility proteomic studies. complexities optimize workflow improve results. comprehensive overview strategies using LC-MS, discussing underlying principles key considerations each step. delving into aims aid workflows achieve robust reproducible results, ultimately drive innovations breakthroughs biomedical research healthcare.
Language: Английский
Citations
0
Molecular Oncology, Journal Year: 2025, Volume and Issue: unknown
Published: March 25, 2025
B-cell chronic lymphocytic leukemia (B-CLL) is characterized by highly heterogeneous genomic alterations and altered signaling pathways, with limited studies on its proteome. Our study presents a comprehensive analysis of the proteome phosphoproteome in B-CLL CLL-like monoclonal lymphocytosis (MBL) primary cells. Using high-resolution mass spectrometry, we identified 2970 proteins 316 phosphoproteins across five tumor samples, including 55 newly phosphopeptides (ProteomeXchange-PXD005997). multifaceted approach also integrated protein microarrays western blotting for further data validation new patient cohort 14 patients. Despite sharing 73% their proteomes, phosphoproteomes varied significantly among independent cytogenetic immunoglobulin heavy variable cluster (IGHV) mutational status. We common functional hallmarks MBL phosphoproteomes, notably tonic (low-level, constitutive signaling) antigen-specific receptor (BCR) nuclear factor NF-kappa-B (NF-kβ)/signal transducer activator transcription 3 (STAT3) pathways. Nine involved BCR were validated, showing high correlation early disease stages. advances field providing detailed perspective cells, revealing pathways crucial development progression. Integrating diverse proteomics techniques identifying novel offers insights into CLL biology, potentially informing future therapeutic strategies biomarker diagnosis personalized treatment.
Language: Английский
Citations
0
Clinica Chimica Acta, Journal Year: 2025, Volume and Issue: unknown, P. 120302 - 120302
Published: April 1, 2025
Language: Английский
Citations
0
Food Chemistry X, Journal Year: 2024, Volume and Issue: 23, P. 101691 - 101691
Published: July 23, 2024
This work investigated the functional changes in whey proteins obtained from goat milk subject to various temperature treatments. Ultra-high instantaneous sterilization (UHTIS) caused less damage than common low-temperature, whereas spray-drying treatment had opposite effect. A total of 426 were identified UHTIS and control groups, including 386 16 14 unique proteins. The upregulated 55 while down-regulated 98. UHTIS-treated may upregulate three metabolic pathways but downregulate one. Overall, only slightly impacted composition functions compared low-temperature
Language: Английский
Citations
3
Children, Journal Year: 2024, Volume and Issue: 11(10), P. 1174 - 1174
Published: Sept. 26, 2024
Multisystem Inflammatory Syndrome in Children (MIS-C) is a post-infectious complication of COVID-19. MIS-C has overlapping features with other pediatric inflammatory disorders including Kawasaki Disease (KD), Macrophage Activation (MAS), Toxic Shock and sepsis. The exact mechanisms responsible for the clinical overlap between these conditions remain unclear, biomarkers that could distinguish from its mimics are lacking. This study aimed to provide an overview how proteomic methods, like Mass Spectrometry (MS) affinity-based proteomics, can offer detailed understanding pathophysiology aid diagnosis prognosis MIS-C.
Language: Английский
Citations
2
Archives of Dermatological Research, Journal Year: 2024, Volume and Issue: 316(10)
Published: Oct. 26, 2024
Language: Английский
Citations
2
iScience, Journal Year: 2024, Volume and Issue: 27(10), P. 110875 - 110875
Published: Sept. 3, 2024
Language: Английский
Citations
1