Stemness of Cancer: A Study of Triple-negative Breast Cancer From a Neuroscience Perspective DOI Creative Commons
Mustafa B.A. Djamgoz

Stem Cell Reviews and Reports, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 12, 2024

Abstract Stemness, giving cancer cells massive plasticity enabling them to survive in dynamic (e.g. hypoxic) environments and become resistant treatment, especially chemotherapy, is an important property of aggressive tumours. Here, we review some essentials stemness focusing on triple-negative breast (TNBC), the most form all cancers. TNBC express a range genes mechanisms associated with stemness, including fundamental four “Yamanaka factors”. Most evidence concerns transcription factor / oncogene c-Myc interesting case expression neonatal splice variant voltage-gated sodium channel subtype Nav1.5. On whole, measures that reduce make less aggressive, reducing their invasive/metastatic potential increasing/restoring chemosensitivity. Such include gene silencing techniques, epigenetic therapies as well novel approaches like optogenetics aiming modulate plasma membrane voltage. Indeed, simply hyperpolarizing can stem differentiate. Finally, give overview clinical aspects exploitation cancer/TNBC diagnostics therapeutics. In particular, personalised mRNA-based mechanistically meaningful combinations are promising emerging discipline ‘cancer neuroscience’ providing insights both issues applications. Graphical

Language: Английский

Intricate relationship between cancer stemness, metastasis, and drug resistance DOI Creative Commons
Tikam Chand Dakal, Ravi Bhushan, Caiming Xu

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(10)

Published: Sept. 21, 2024

Cancer stem cells (CSCs) are widely acknowledged as the drivers of tumor initiation, epithelial-mesenchymal transition (EMT) progression, and metastasis. Originating from both hematologic solid malignancies, CSCs exhibit quiescence, pluripotency, self-renewal akin to normal cells, thus orchestrating heterogeneity growth. Through a dynamic interplay with microenvironment (TME) intricate signaling cascades, undergo transitions differentiated cancer culminating in therapy resistance disease recurrence. This review undertakes an in-depth analysis multifaceted mechanisms underlying stemness CSC-mediated therapy. Intrinsic factors encompassing TME, hypoxic conditions, oxidative stress, alongside extrinsic processes such drug efflux mechanisms, collectively contribute therapeutic resistance. An exploration into key pathways, including JAK/STAT, WNT, NOTCH, HEDGEHOG, sheds light on their pivotal roles sustaining phenotypes. Insights gleaned preclinical clinical studies hold promise refining discovery efforts optimizing interventions, especially chimeric antigen receptor (CAR)-T cell therapy, cytokine-induced killer (CIK) natural (NK) cell-mediated CSC-targeting others. Ultimately use sorting single sequencing approaches for elucidating fundamental characteristics inherent will enhance our comprehension CSC intratumor heterogeneity, which ultimately would inform about tailored personalized interventions.

Language: Английский

Citations

9
Hotspots and trends in gastric cancer stem cell research: a visualization and bibliometric analysis DOI Creative Commons
Jinfeng Liu, Xiaoxu Han,

Qingyi Wang

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: March 5, 2025

Gastric cancer (GC) is a type of malignant tumor that seriously endangers human health. As the understanding mechanisms underlying gastric deepens, in recent years, investigations on stem cells (GCSCs) have garnered significant interest. They are pivotal onset, progression, recurrence, and pharmacoresistance GC. Comprehensive research GCSCs expected to provide new strategies for diagnosis treatment This article endeavors comprehensively assess current status future trends through bibliometric analysis, thereby providing valuable reference further - depth studies this field. English language academic journals related Web Science database were retrieved. Subsequently, VOSviewer was utilized conduct network collinear analysis exported source institutions, literature authors, references, keywords. And CiteSpace used perform statistical annual publication count, keyword clustering, burst. A total 3882 documents met criteria incorporated. The quantity published papers has shown consistent upward trend annually since 2003. Among authors literature, multiple stable core author groups represented by Zhu, Wei, Wang, Mei, Xu, Wenrong, etc. been formed. There 335 associated institutions total. Japan National Cancer Center strongest relevance largest number papers. 7 clustering labels formed among keywords, including main modules such as activation, cells, DNA content aneuploidy, expression. 25 burst keywords generated, past two years include mesenchymal drug resistance, proliferation, emergence references indicates eight cited up now focus research. overview 30 visually presented visual maps. In decade, scholars' field gradually intensified, development good. Through deeper study mechanism, intervention will be promising approach GC patients. hot topic still deserves more attention future.

Language: Английский

Citations

0
Stemness of Cancer: A Study of Triple-negative Breast Cancer From a Neuroscience Perspective DOI Creative Commons
Mustafa B.A. Djamgoz

Stem Cell Reviews and Reports, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 12, 2024

Abstract Stemness, giving cancer cells massive plasticity enabling them to survive in dynamic (e.g. hypoxic) environments and become resistant treatment, especially chemotherapy, is an important property of aggressive tumours. Here, we review some essentials stemness focusing on triple-negative breast (TNBC), the most form all cancers. TNBC express a range genes mechanisms associated with stemness, including fundamental four “Yamanaka factors”. Most evidence concerns transcription factor / oncogene c-Myc interesting case expression neonatal splice variant voltage-gated sodium channel subtype Nav1.5. On whole, measures that reduce make less aggressive, reducing their invasive/metastatic potential increasing/restoring chemosensitivity. Such include gene silencing techniques, epigenetic therapies as well novel approaches like optogenetics aiming modulate plasma membrane voltage. Indeed, simply hyperpolarizing can stem differentiate. Finally, give overview clinical aspects exploitation cancer/TNBC diagnostics therapeutics. In particular, personalised mRNA-based mechanistically meaningful combinations are promising emerging discipline ‘cancer neuroscience’ providing insights both issues applications. Graphical

Language: Английский

Citations

0