Exploring the Frontier of Inhalation Therapy: A Review of Dry Powder Inhalers for Precision Management of Inflammatory Lung Diseases DOI Creative Commons

Amir R. Tamboli,

Vibha Yadav, Sameer Nadaf

et al.

BIO Integration, Journal Year: 2024, Volume and Issue: 5(1)

Published: Jan. 1, 2024

Abstract Chronic respiratory diseases impose a substantial health burden globally with increasing prevalence and mortality rates, especially in affluent nations. Recent studies underscore the escalating contribution to premature morbidity mortality, highlighting critical need for effective interventions. Inflammatory lung diseases, such as asthma, chronic obstructive pulmonary disease (COPD), acute distress syndrome (ARDS), idiopathic fibrosis (IPF), have significant roles this that are characterized by heightened inflammation affecting airways or parenchyma, leading restrictive diseases. These conditions often exhibit components, which complicate classification management. Current treatments illnesses predominantly rely on systemic drug delivery, may result poor efficacy adverse effects other organs. Inhalation delivery presents promising alternative, offering advantages, targeted deposition, reduced side effects, rapid onset of action. Despite these benefits, inhalation systems still developmental stage, particularly local delivery. Dry powder inhalers (DPIs) emerged popular choice due ease use, high-dose capability, breath-activated mechanisms. This review delves into intriguing world spotlight DPIs. From fascinating design principles potential precision medicine, DPIs offer glimpse future care. By unravelling mysteries DPI formulation performance assessment, aimed propel field forward, ushering new era personalized efficacious therapies inflammatory beyond. Furthermore, article delved identification prevalent technologies within domain while also probing prospective avenues emerging development. Such insights aim assist researchers making informed decisions regarding relevant research development pursuits.

Language: Английский

Interfacial Adsorption Interactions of Dyes and Chitosan/Activated Carbon@Curcumin Derivatives in Single-Component and Binary Solutions DOI Creative Commons

Angeliki A. Kouzoutzoglou-Efremidou,

Athanasia K. Tolkou, Konstantinos N. Maroulas

et al.

Langmuir, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

The remediation of wastewaters contaminated with dyes (discharged mainly from industry) is very important for preserving environmental quality and human health. In this study, a new composite chitosan (CS)-based adsorbent combined activated carbon (AC) curcumin (Cur) (abbreviated hereafter as CS/AC@Cur) in three different ratios (12.5%, 25%, 50%) was synthesized the removal anionic [reactive black 5 (RB5)] cationic [methylene blue (MB)] single-component or binary systems. materials were completely characterized through Fourier transform infrared spectroscopy, scanning electron microscopy, Brunauer-Emmett-Teller analysis, X-ray diffraction. Specifically, decrease surface area CS/AC@ observed addition curcumin, 163 to 18 m2/g, all CS/AC@Cur derivatives. terms adsorption results, optimal derivative both RB5 MB found be CS/AC@Cur50%, providing 93% at pH 2.0 ± 0.1 54% optimum 9.0 due electrostatic attractions. Elovich pseudo-second-order kinetic model, correlation coefficient R2 >0.98, better tailored indicating that controlled by chemisorption. addition, Sips (Langmuir-Freundlich) isotherm model fitted calculated capacities 338 307 mg/g MB, respectively. thermodynamic analysis showed spontaneous endothermic procedure, chemisorption main mechanism. Reuse experiments efficiency retained high levels, while stability studies revealed retains its structural integrity, even extreme values. Finally, mixed solution investigated, competitive effect between dyes.

Language: Английский

Citations

2
Comprehensive Aerodynamic and Physicochemical Stability Evaluations of Nanocrystal-Based Dry Powder Inhalers: The Role of Mannitol and Leucine in Enhancing Performance DOI Creative Commons
Heba Banat, Attila Nagy, Árpád Farkas

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 436 - 436

Published: March 28, 2025

Background: Nanocrystals, a carrier-free nanotechnology, offer significant advantages for pulmonary drug delivery by enhancing the dissolution and solubility of poorly soluble drugs while maintaining favorable biological properties low toxicity. This study aims to investigate aerodynamic performance stability nanocrystal-based dry powders (NC-DPs). Methods: Nanocrystalline suspensions were produced via wet media milling subjected studies before undergoing nano spray drying. A factorial design was employed optimize process parameters. The influence mannitol leucine, individually in combination, evaluated terms (Aerodynamic Particle Sizer (APS), silico modeling) physicochemical at room temperature (in desiccator) accelerated conditions (40 ± 2 °C, 75 5% relative humidity). Results: APS analysis revealed that leucine-containing (K-NC-Ls) exhibited smallest median (1.357 µm) geometric mean (1.335 particle sizes, dispersibility. However, results indicated highest exhaled fraction K-NC-L, highlighting need optimized excipient selection. Although showed lowest fraction, it mainly deposited extra-thoracic region silico. mannitol/leucine combination (K-NC-ML) high lung deposition Also, K-NC-ML demonstrated superior stability, with 6% reduction D[0.5] decrease span overtime. Furthermore, no changes crystallinity, thermal behavior, release, or mass diameter observed under stress conditions. Conclusions: These findings confirm combined incorporation leucine NC-DP formulations enhances performance, making promising approach delivery.

Language: Английский

Citations

1
Mannitol-Leucine synergy in nanocrystal agglomerates for enhanced systemic delivery of inhaled Ketoprofen: Pharmacokinetics and safety in Ovalbumin-Sensitized rats DOI Creative Commons
Heba Banat, Ildikó Csóka,

Fruzsina Kun-Szabó

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125610 - 125610

Published: April 1, 2025

Language: Английский

Citations

0
Exploring the Frontier of Inhalation Therapy: A Review of Dry Powder Inhalers for Precision Management of Inflammatory Lung Diseases DOI Creative Commons

Amir R. Tamboli,

Vibha Yadav, Sameer Nadaf

et al.

BIO Integration, Journal Year: 2024, Volume and Issue: 5(1)

Published: Jan. 1, 2024

Abstract Chronic respiratory diseases impose a substantial health burden globally with increasing prevalence and mortality rates, especially in affluent nations. Recent studies underscore the escalating contribution to premature morbidity mortality, highlighting critical need for effective interventions. Inflammatory lung diseases, such as asthma, chronic obstructive pulmonary disease (COPD), acute distress syndrome (ARDS), idiopathic fibrosis (IPF), have significant roles this that are characterized by heightened inflammation affecting airways or parenchyma, leading restrictive diseases. These conditions often exhibit components, which complicate classification management. Current treatments illnesses predominantly rely on systemic drug delivery, may result poor efficacy adverse effects other organs. Inhalation delivery presents promising alternative, offering advantages, targeted deposition, reduced side effects, rapid onset of action. Despite these benefits, inhalation systems still developmental stage, particularly local delivery. Dry powder inhalers (DPIs) emerged popular choice due ease use, high-dose capability, breath-activated mechanisms. This review delves into intriguing world spotlight DPIs. From fascinating design principles potential precision medicine, DPIs offer glimpse future care. By unravelling mysteries DPI formulation performance assessment, aimed propel field forward, ushering new era personalized efficacious therapies inflammatory beyond. Furthermore, article delved identification prevalent technologies within domain while also probing prospective avenues emerging development. Such insights aim assist researchers making informed decisions regarding relevant research development pursuits.

Language: Английский

Citations

0