Sweet Potato Peel Pectin's Potential as a Suspending Agent in Pharmaceutical Formulations: The Effect of Extraction Technique

Journal of Pharmacy, Journal Year: 2025, Volume and Issue: 5(1), P. 57 - 72

Published: Jan. 31, 2025

Introduction: Sweet potato (Ipomoea batatas L. Lam) represents an essential underutilised crop globally. The ubiquitous hydrocolloid, pectin, with versatile pharmaceutical and cosmetic applications has been reported to be abundant in the peels. This study thus examined impact of acid (citric acid) alkaline (sodium hydroxide) extraction procedures on suitability pectin extracted from sweet peels as a biocompatible economical alternative suspending agent. Methods: Conventional were utilised followed by characterisation phytochemical evaluation. proximate composition, FTIR spectra, secondary metabolites degree esterification determined. Additionally, different concentrations (1% 2%) pectins formulating paracetamol suspensions using acacia gum reference assessed for quality. Results: Secondary present all while yield was 9.04±0.07 7.24±0.25 respectively methods. Quality high methoxyl significant differences (p<0.05) parameters (Equivalent weight=1666.67 1250mg/mol; content=16.43 9.57% respectively) except ash content (3.12 2.95 % obtained. highlighted characteristic functional groups pectin. Both demonstrated good however, variable flow rates, re-dispersibility, sedimentation volumes compared gum. pH remained mildly acidic (<7) no physical instabilities. Conclusion: exhibited better-suspending property than extract. Nevertheless, they both can

Language: Английский

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Influence of Core Starch and Lignocellulosic Fibers from Plantain (Musa paradisiaca L.) Pseudostem on the Development of Thermoplastic Starches and Biobased Composite Materials

Polymers, Journal Year: 2025, Volume and Issue: 17(7), P. 859 - 859

Published: March 23, 2025

As the demand for sustainable and environmentally friendly materials has increased, renewable resources have been explored development of biobased composites. Two composite were developed from thermoplastic starch (TPS), short fibers plantain pseudostems sheaths pseudostem core, using twin-screw extrusion compression molding. Based on findings, there is evidence a material with reduced water absorption up to 9.9%, keeping thermal stability at degradation temperature between 300 306 °C increasing tensile properties by over 506%, although hardness showed slight increases (4.6%). In addition, capacity sheath generate vapor barrier highlighted reducing magnitude losses in mechanical during storage period 8 days. This study contributes use agricultural residues create products, offering pathway toward dependency synthetic polymers mitigating environmental impact.

Language: Английский

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Green Hydrogels Prepared from Pectin Extracted from Orange Peels as a Potential Carrier for Dermal Delivery Systems

ACS Omega, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Language: Английский

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Biogenic Waste from Two Varieties of Plantain in Ghana Contain Pectin with Potential Binding Properties in Conventional Tablets

The Scientific World JOURNAL, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Pharmaceutical formulations have traditionally relied on plants and their derivatives for various APIs excipients. In Ghana, the widespread utilization of plantains, irrespective ripeness, generates significant waste at every stage processing, posing disposal issues. Fascinatingly, these wastes, often discarded, possess economic potential can be recycled into valuable raw materials or products. Pectin, a polysaccharide that occurs naturally, has seen surge in interest recent times. It found use pharmaceutical sector, particularly as binding agent tablet formulations. This study aimed to evaluate pectin from two popular plantain varieties, Apem (M) Apantu (T) different ripening stages, immediate‐release tablets. The stages selected were matured‐green (G), half‐ripe (H), full‐ripe (R). Acid (D) alkaline (L) mediums extraction employed each both varieties. Wet granulation method was used prepare granules using paracetamol model drug, flow properties subsequently assessed. Postcompression tests including, hardness, friability, weight uniformity, disintegration, assay, vitro dissolution also Granules all formulation batches had good indicated by angle repose (14.93 ± 1.41–21.80 1.41), Hausner ratio (0.96 0.27–1.22 0.02), compressibility (%) (7.69 0.002–20.51 0.002). All tablets passed uniformity with none deviating ±5%. hardness formulated ranged between 3.96 0.32 13.21 0.36, while friability below 1%. drug content 100.1 0.23% 103.4 0.01%. Tablets concentrations 10% w/v 15% successfully met disintegration test criteria immediate release However, those prepared concentration 20% (MGL, MHD, MHL, MRD, MRL, TGL, THD, THL, TRL) did not pass test. Consequently, requirement (Diss, Q > 75%), except < 75%). Ultimately, pectins extracted peels acid commercially exploited binders varying

Language: Английский

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Insights into the non-covalent interaction between muskmelon peel pectin and selected C9 aldehydes by the application of multiple spectroscopy and molecular docking

Food Hydrocolloids, Journal Year: 2024, Volume and Issue: unknown, P. 110982 - 110982

Published: Dec. 1, 2024

Language: Английский

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