Polyherbal renal tea extract shows anti-inflammatory and antioxidant effects against gentamicin-induced nephrotoxicity in guinea pigs DOI Open Access

Joshua Asante,

Aliu Moomin, Michael Ofori

et al.

Egyptian Journal of Basic and Applied Sciences, Journal Year: 2024, Volume and Issue: 12(1), P. 1 - 15

Published: Dec. 31, 2024

Renal diseases pose a tremendous economic burden worldwide, and the only treatment options are renal transplantation dialysis, which remain unaffordable to low-income people. This study evaluated potential of polyherbal tea extract (RTE) as remedy for kidney disease using gentamicin-induced damage model in guinea pigs. Polyherbal was purchased from market extracted with 70% ethanol. RTE phytochemicals were screened qualitatively chemoprofiled by High-performance liquid chromatography. Acute sub-acute toxicity studies on carried out. To investigate possible effects RTE, groups animals received either gentamicin intraperitoneally alone or combination oral administration (200, 600 1000 mg/kg/day) 14 days. On day 15, biochemical markers inflammation assessed. The caused no significant changes blood biochemistry histomorphology, LD50 >5000 mg/kg. Significantly (p<0.001) reduced serum creatinine urea levels observed when compared gentamicin-treated group. also showed significantly increased superoxide dismutase catalase activities malondialdehyde, IL-6 TNF-α protects against nephrotoxicity pigs through its antioxidant anti-inflammatory effects.

Language: Английский

Measurement of four main catechins content in green tea based on visible and near-infrared spectroscopy using optimized machine learning algorithm DOI
Wei Luo,

Wayne Jason Li,

Shilin Liu

et al.

Journal of Food Composition and Analysis, Journal Year: 2024, Volume and Issue: 138, P. 106990 - 106990

Published: Nov. 17, 2024

Language: Английский

Citations

1
Phytochemistry and bioactives of ingredient plants of a Polyherbal formulation DOI

C. T. Sulaiman,

G R Advaya,

T Shafna

et al.

Next research., Journal Year: 2024, Volume and Issue: unknown, P. 100078 - 100078

Published: Nov. 1, 2024

Language: Английский

Citations

0
Polyherbal renal tea extract shows anti-inflammatory and antioxidant effects against gentamicin-induced nephrotoxicity in guinea pigs DOI Open Access

Joshua Asante,

Aliu Moomin, Michael Ofori

et al.

Egyptian Journal of Basic and Applied Sciences, Journal Year: 2024, Volume and Issue: 12(1), P. 1 - 15

Published: Dec. 31, 2024

Renal diseases pose a tremendous economic burden worldwide, and the only treatment options are renal transplantation dialysis, which remain unaffordable to low-income people. This study evaluated potential of polyherbal tea extract (RTE) as remedy for kidney disease using gentamicin-induced damage model in guinea pigs. Polyherbal was purchased from market extracted with 70% ethanol. RTE phytochemicals were screened qualitatively chemoprofiled by High-performance liquid chromatography. Acute sub-acute toxicity studies on carried out. To investigate possible effects RTE, groups animals received either gentamicin intraperitoneally alone or combination oral administration (200, 600 1000 mg/kg/day) 14 days. On day 15, biochemical markers inflammation assessed. The caused no significant changes blood biochemistry histomorphology, LD50 >5000 mg/kg. Significantly (p<0.001) reduced serum creatinine urea levels observed when compared gentamicin-treated group. also showed significantly increased superoxide dismutase catalase activities malondialdehyde, IL-6 TNF-α protects against nephrotoxicity pigs through its antioxidant anti-inflammatory effects.

Language: Английский

Citations

0