Medicinal Research Reviews, Journal Year: 2025, Volume and Issue: unknown
Published: March 12, 2025
ABSTRACT The development of standard drugs for some unusual cancers, including estrogen‐nonresponsive breast cancer, is somewhat difficult within a very short time. So, considering the current situation, phytoestrogen may be potential candidate unraveling chemotherapeutics agents. reason this review article to manifest overall information regarding effects on triple‐negative cancer (TNBC), along with its related cellular and molecular pathways in different TNBC models. Data was retrieved by systematic searches according PRISMA guidelines, commonly used tools servers are BioRender, ChemDraw professional 16.0, Schrodinger, ADMETlab 2.0. caused due dysregulation several signaling mechanisms such as Wnt/β‐catenin, hedgehog, MAPK, notch, PI3K/AKT/mTOR, hippo, NF‐κB, JAK/STAT cascades. Among all phytoestrogens ( n = 150), 48 compounds therapeutically effective vitro preclinical Chemotherapeutics activities regulated through varieties mechanisms, targeting phosphor‐Akt, TNF‐α; apoptosis FASL, Bcl2, Bax, Bak, Bad, apfa1, ASK1, Capase, PARP; metastasis MMPs (1,2,3,9), Wnt/‐β catenin, angiogenesis (E&N Cadherin, Vimentin), cell proliferation (cyclins‐A, B1, D1, E1, CDKs 1, 6,7), inflammatory molecules (TNF‐α, IL‐1β, IL‐8), regulating tumor suppressor genes (p21, p27, p51, p53) nonspecific like DNA damage repair (γH2AX, RAD51, surviving), autophagy (mTOR, ULK1, cathepsin B), epigenetic (HDAC1, DNMT1, telomerase production) metabolism regulation (glucose regulation‐GLUT1 GLUT4), showing antioxidant many other pathways. Some selective exert synergistic conventional well radiotherapy mechanism reverse drug resistance EMT process, pathways, sensitizing, miRNA regulation, improving uptake. Nano‐based can target cells, stimulate accumulation, improve efficacies, making more agents treating TNBC. Additionally, an in‐silico pharmacokinetics study reveals that possesses suitable pharmacokinetic characteristics minor toxicity. against until fully pharma available at markets.
Language: Английский