Oxidative Stress‐Related Targets POR and MAPK13 Elucidated for Sarcoidosis Therapy Through Multiomics Analysis DOI Creative Commons
Yang Xun, Hao Jiang, Xiaoyun Li

et al.

International Journal of Clinical Practice, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Purpose: We aimed to identify potential plasma protein targets genetically associated with oxidative stress genes in sarcoidosis. Methods: performed summary data‐based Mendelian randomization (SMR) analyses using statistics from the FinnGen cohorts and multiomics data on quantitative trait loci (QTLs) linked at protein, RNA, methylation levels. validated findings two independent datasets published studies. Bayesian colocalization analysis confirmed shared genetic bases excluded pleiotropy. also identified relevant regulatory transcription factors (TFs) constructed protein–protein interaction (PPI) networks. In addition, molecular docking was conducted for drug ligand‐protein binding assays. Results: MAPK13 POR were as significant proteome‐wide SMR, transcriptome‐wide methylation‐wide SMR analyses. These through additional sarcoidosis cohorts. PSMR analysis, A allele of rs10447396 near (p38 δ ) ( p = 0.0068 β 0.6009) rs59882870 0.0006 0.3924) increased risk. NFATC3 NFKB1 common TFs influencing expression plasma. Molecular MAPK13‐targeting drugs, ilorasertib SNS‐314, both showing strong affinities MAPK13. Conclusion: This study is first preliminarily therapeutic compounds targeting these proteins, suggesting avenues future experimental validation development targeted therapies.

Language: Английский

Research Progress on the Therapeutic Mechanisms of Stigmasterol for Multiple Diseases DOI Creative Commons
Juan Li, Xinhua Zheng, Jinxu Qi

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(9), P. 1874 - 1874

Published: April 23, 2025

Stigmasterol is a plant-derived phytosterol that has attracted considerable attention because of its diverse biological activities and potential therapeutic applications. In this review, the chemical properties, biosynthesis, effects stigmasterol are exhaustively summarized. Furthermore, anti-inflammatory, antioxidant, anticancer, neuroprotective, hypolipidemic have been discussed. Findings from various in vitro vivo studies revealed treating diseases, including cancer, diabetes, neurological disorders, inflammatory conditions. The mechanisms underlying these also discussed, particularly emphasizing regulation key signaling pathways molecular targets, to further clarify role stigmasterol. This review would provide reference for exploring utility as agent, thereby contributing improvement human health.

Language: Английский

Citations

0
Oxidative Stress‐Related Targets POR and MAPK13 Elucidated for Sarcoidosis Therapy Through Multiomics Analysis DOI Creative Commons
Yang Xun, Hao Jiang, Xiaoyun Li

et al.

International Journal of Clinical Practice, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Purpose: We aimed to identify potential plasma protein targets genetically associated with oxidative stress genes in sarcoidosis. Methods: performed summary data‐based Mendelian randomization (SMR) analyses using statistics from the FinnGen cohorts and multiomics data on quantitative trait loci (QTLs) linked at protein, RNA, methylation levels. validated findings two independent datasets published studies. Bayesian colocalization analysis confirmed shared genetic bases excluded pleiotropy. also identified relevant regulatory transcription factors (TFs) constructed protein–protein interaction (PPI) networks. In addition, molecular docking was conducted for drug ligand‐protein binding assays. Results: MAPK13 POR were as significant proteome‐wide SMR, transcriptome‐wide methylation‐wide SMR analyses. These through additional sarcoidosis cohorts. PSMR analysis, A allele of rs10447396 near (p38 δ ) ( p = 0.0068 β 0.6009) rs59882870 0.0006 0.3924) increased risk. NFATC3 NFKB1 common TFs influencing expression plasma. Molecular MAPK13‐targeting drugs, ilorasertib SNS‐314, both showing strong affinities MAPK13. Conclusion: This study is first preliminarily therapeutic compounds targeting these proteins, suggesting avenues future experimental validation development targeted therapies.

Language: Английский

Citations

0