From pox to protection: understanding Monkeypox pathophysiology and immune resilience DOI Creative Commons

Alagammai Ganesan,

Thirumalai Arunagiri,

Suganandhini Mani

et al.

Tropical Medicine and Health, Journal Year: 2025, Volume and Issue: 53(1)

Published: Feb. 26, 2025

Abstract The Monkeypox virus (MPXV), which causes (Mpox) is an invasive ailment with global implications. MPXV, categorized within the Orthopoxvirus genus, exhibits diverse clades varying fatality rates. Initially discovered in monkeys and later humans, disease predominantly affects regions across West Central Africa. Clinical manifestations encompass a spectrum from mild flu-like symptoms to severe eruptions. This article aims give scientific community comprehensive overview of Mpox Pathophysiology delve into intricate landscape host immune responses against MPXV infection. It offers crucial insights virus's Pathophysiology, spanning its entry, replication, dissemination, elicited responses. reaction involves innate immunity, B-cell T-cell immunity. Moreover, this review underscores immunological response resistance mechanisms MPXV. also highlights imperative research areas warranting prioritization devise more efficacious treatments for controlling viral propagation healthcare systems. In addition, it gives us look possible futures that could help progress immunotherapies cutting-edge biotechnological solutions protecting

Language: Английский

From pox to protection: understanding Monkeypox pathophysiology and immune resilience DOI Creative Commons

Alagammai Ganesan,

Thirumalai Arunagiri,

Suganandhini Mani

et al.

Tropical Medicine and Health, Journal Year: 2025, Volume and Issue: 53(1)

Published: Feb. 26, 2025

Abstract The Monkeypox virus (MPXV), which causes (Mpox) is an invasive ailment with global implications. MPXV, categorized within the Orthopoxvirus genus, exhibits diverse clades varying fatality rates. Initially discovered in monkeys and later humans, disease predominantly affects regions across West Central Africa. Clinical manifestations encompass a spectrum from mild flu-like symptoms to severe eruptions. This article aims give scientific community comprehensive overview of Mpox Pathophysiology delve into intricate landscape host immune responses against MPXV infection. It offers crucial insights virus's Pathophysiology, spanning its entry, replication, dissemination, elicited responses. reaction involves innate immunity, B-cell T-cell immunity. Moreover, this review underscores immunological response resistance mechanisms MPXV. also highlights imperative research areas warranting prioritization devise more efficacious treatments for controlling viral propagation healthcare systems. In addition, it gives us look possible futures that could help progress immunotherapies cutting-edge biotechnological solutions protecting

Language: Английский

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