Mitochondria-Targeted Biomaterials-Regulating Macrophage Polarization Opens New Perspectives for Disease Treatment

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 1509 - 1528

Published: Feb. 1, 2025

Abstract: Macrophage immunotherapy is an emerging therapeutic approach designed for modulating the immune response to alleviate disease symptoms. The balance between pro-inflammatory and anti-inflammatory macrophages plays a pivotal role in progression of inflammatory diseases. Mitochondria, often referred as "power plants" cell, are essential organelles responsible critical functions such energy metabolism, material synthesis, signal transduction. functional state mitochondria closely linked macrophage polarization, prompting interest strategies that target regulate this process. To end, biomaterials with excellent targeting capabilities effective properties have been developed influence mitochondrial function polarization. However, comprehensive summary biomaterial-driven modulation control phenotypes still lacking. This review highlights polarization discusses mediated by biomaterials, including mitochondria-targeted biomaterials. Finally, prospects challenges use these explored, emphasizing their potential be translated clinic. It anticipated will serve valuable resource materials scientists clinicians development next-generation Keywords: macrophages,

Language: Английский

The Landscape of Malignant Transition: Unraveling Cancer Cell-of-Origin and Heterogeneous Tissue Microenvironment

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217591 - 217591

Published: March 1, 2025

Language: Английский