Exosomal circRNAs: key modulators in breast cancer progression DOI Creative Commons
Guozhen Liu, Quan Liu,

Lingmei Jia

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 24, 2025

Abstract Breast cancer (BC) poses significant challenges globally, necessitating a deeper understanding of its complexities. Exosomes are cell-specific secreted extracellular vesicles interest, characterized by lipid bilayer structure. can carry variety bioactive components, including nucleic acids, lipids, amino and small molecules, to mediate intercellular signaling. CircRNAs novel class single-stranded RNA closed-loop mainly exert ceRNA functions intricately modulate gene expression signaling pathways in breast cancer, influencing tumor progression therapeutic responses. The unique packaging circRNAs within exosomes serves as genetic information transmitters, facilitating communication between BC cells microenvironmental cells, thereby regulating critical aspects progression, immune evasion, drug resistance. Besides, exosomal possess the capabilities serving diagnostic biomarkers BC, due their stability, specificity, regulatory roles tumorigenesis metastasis. Therefore, this review aims elucidate mechanisms well potential for diagnosis therapeutics. ongoing investigations will potentially revolutionize treatment paradigms improve patient outcomes BC.

Language: Английский

Exosomal circRNAs: key modulators in breast cancer progression DOI Creative Commons
Guozhen Liu, Quan Liu,

Lingmei Jia

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 24, 2025

Abstract Breast cancer (BC) poses significant challenges globally, necessitating a deeper understanding of its complexities. Exosomes are cell-specific secreted extracellular vesicles interest, characterized by lipid bilayer structure. can carry variety bioactive components, including nucleic acids, lipids, amino and small molecules, to mediate intercellular signaling. CircRNAs novel class single-stranded RNA closed-loop mainly exert ceRNA functions intricately modulate gene expression signaling pathways in breast cancer, influencing tumor progression therapeutic responses. The unique packaging circRNAs within exosomes serves as genetic information transmitters, facilitating communication between BC cells microenvironmental cells, thereby regulating critical aspects progression, immune evasion, drug resistance. Besides, exosomal possess the capabilities serving diagnostic biomarkers BC, due their stability, specificity, regulatory roles tumorigenesis metastasis. Therefore, this review aims elucidate mechanisms well potential for diagnosis therapeutics. ongoing investigations will potentially revolutionize treatment paradigms improve patient outcomes BC.

Language: Английский

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