Remodeling tumor-associated macrophages in the tumor microenvironment

Oncology and Translational Medicine, Journal Year: 2024, Volume and Issue: 10(6), P. 281 - 285

Published: Sept. 11, 2024

Abstract Tumor-associated macrophages (TAMs) actively interact with the tumor microenvironment (TME). The dynamic communication between TAMs and TME is closely associated tumorigenesis, progression, metastasis, drug resistance. With development of single-cell sequencing, specific have been identified, their roles in were explored. an understanding interactions TME, targeting has become a new treatment strategy for cancer therapy because high plasticity. In this review, we highlight strategies remodeling based on genes involved regulating TAM phenotypes, blocking crosstalk abnormal metabolic pathways. Moreover, provided perspectives translational potential treatment, which could shed light TAM-based therapeutic future.

Language: Английский

The Regulation and Function of the Amino Acid Transporters LAT1, ASCT2, xCT in Urological Cancers

Receptors, Journal Year: 2024, Volume and Issue: 3(4), P. 474 - 493

Published: Oct. 31, 2024

Amino acid transporters play pivotal roles in cancer biology, including urological cancers. Among them, L-type amino transporter 1 (LAT1), alanine-serine-cysteine 2 (ASCT2), and cystine-glutamate (xCT) have garnered significant attention due to their involvement various aspects of tumor progression response therapy. This review focuses on elucidating the regulation functions these cancers, prostate, bladder, renal Understanding intricate regulatory mechanisms governing is essential for developing effective therapeutic strategies. Furthermore, exploring interactions with signaling pathways microenvironmental cues context cancers may uncover novel vulnerabilities. comprehensive overview highlights importance transporters, particularly LAT1, ASCT2, xCT, underscores potential inhibitors as targets improving patient outcomes.

Language: Английский

Metabolic dynamics of tumor-associated macrophages: Implications for cancer therapy

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский