Colorectal Organoids: Models, Imaging, Omics, Therapy, Immunology, and Ethics DOI Creative Commons
Martina Taglieri,

Linda Di Gregorio,

Serena Matis

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(6), P. 457 - 457

Published: March 19, 2025

Colorectal epithelium was the first long-term 3D organoid culture established in vitro. Identification of key components essential for survival stem cell niche allowed an indefinite propagation these cultures and modulation their differentiation into various lineages mature intestinal epithelial cells. While methods were eventually adapted to establish organoids from different organs, colorectal remain a pioneering model development new applications health disease. Several basic applicative aspects culture, modeling, monitoring testing are analyzed this review. We also tackle ethical problems biobanking distribution precious research tools, frequently confined laboratory origin or condemned destruction at end project.

Language: Английский

Unraveling UPR-Mediated Intercellular Crosstalk: Implications for Immunotherapy Resistance Mechanisms DOI
Lu Si, Qimin Zhou, Rongjie Zhao

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217613 - 217613

Published: March 1, 2025

Language: Английский

Citations

2
Homeostasis control in health and disease by the unfolded protein response DOI
Diego Acosta‐Alvear, Jonathan M. Harnoss, Peter Walter

et al.

Nature Reviews Molecular Cell Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 5, 2024

Language: Английский

Citations

12
Colorectal Organoids: Models, Imaging, Omics, Therapy, Immunology, and Ethics DOI Creative Commons
Martina Taglieri,

Linda Di Gregorio,

Serena Matis

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(6), P. 457 - 457

Published: March 19, 2025

Colorectal epithelium was the first long-term 3D organoid culture established in vitro. Identification of key components essential for survival stem cell niche allowed an indefinite propagation these cultures and modulation their differentiation into various lineages mature intestinal epithelial cells. While methods were eventually adapted to establish organoids from different organs, colorectal remain a pioneering model development new applications health disease. Several basic applicative aspects culture, modeling, monitoring testing are analyzed this review. We also tackle ethical problems biobanking distribution precious research tools, frequently confined laboratory origin or condemned destruction at end project.

Language: Английский

Citations

0