Journal of Alzheimer s Disease,
Journal Year:
2021,
Volume and Issue:
82(4), P. 1417 - 1450
Published: July 16, 2021
Porphyromonas
gingivalis
(Pg)
is
a
primary
oral
pathogen
in
the
widespread
biofilm-induced
"chronic"
multi-systems
inflammatory
disease(s)
including
Alzheimer's
disease
(AD).
It
possibly
only
second
identified
unique
example
of
biological
extremophile
human
body.
Having
better
understanding
key
microbiological
and
genetic
mechanisms
its
pathogenesis
induction
are
central
to
future
diagnosis,
treatment,
possible
prevention.
The
published
literature
around
role
Pg
AD
highlights
bacteria's
direct
within
brain
cause
disease.
available
evidence,
although
somewhat
adopted,
does
not
fully
support
this
as
major
process.
There
alternative
pathogenic/virulence
features
associated
with
that
have
been
overlooked
may
explain
pathogenic
processes
found
"infection
hypothesis"
AD.
A
explanation
offered
here
for
discrepancy
relatively
low
amounts
"Pg
bacteria"
residing
compared
rather
florid
broad
distribution
one
or
more
bacterial
protein
toxins.
Related
this,
"Gingipains
Hypothesis",
AD-related
iron
dyshomeostasis,
early
reduced
salivary
lactoferrin,
along
resurrection
Cholinergic
Hypothesis
now
be
integrated
into
working
model.
current
paper
suggests
highly
evolved
developed
Type
IX
secretory
cargo
system
producing
outer
membrane
vesicles
observed
diseases.
Thus
it
hoped
can
provide
unifying
model
sporadic
form
guide
direction
research,
Journal of Neuroendocrinology,
Journal Year:
2018,
Volume and Issue:
30(5)
Published: April 3, 2018
In
the
converging
fields
of
neuroendocrinology
and
behavioural
neuroscience,
interaction
between
peripheral
secretion
central
release
oxytocin
in
humans
has
not
yet
been
comprehensively
assessed.
Because
human
brain
is
directly
accessible
collection
cerebrospinal
fluid
(CSF)
usually
requires
invasive
procedures,
easier
compartments
such
as
blood
or
saliva
have
attracted
increasing
attention.
present
study,
we
prospectively
determined
concentrations
3
comprising
plasma,
CSF
50
critically
ill
patients
with
neurological
neurosurgical
diseases.
All
samples
per
patient
were
collected
concomitantly.
Oxytocin
was
measured
by
a
highly
sensitive
specific
radioimmunoassay.
The
strength
correlation
assessed
Spearman
rank
coefficient.
Correlation
analyses
revealed
modest
to
strong
correlations
for
compartments,
whereas
predominantly
weak
found
well
plasma
compartments.
conclusion,
demonstrated
suggesting
that
may
help
assess
levels.
By
contrast,
failed
correspond
levels
because
which
are
unlikely
any
biological
relevance.
Further
research
needed
clarify
what
extent
serve
biomarker
reflecting
activity.
Deleted Journal,
Journal Year:
2023,
Volume and Issue:
2(1), P. 121 - 138
Published: June 6, 2023
The
human
body
has
a
unique
way
of
saying
when
something
is
wrong
with
it.
molecules
in
the
fluids
can
be
helpful
early
detection
diseases
by
enabling
health
and
preventing
disease
progression.
These
biomarkers
better
healthcare
are
becoming
an
extensive
area
research
interest.
Biosensors
that
detect
these
future,
especially
Point
Of
Care
(POC)
biosensors
remove
need
to
physically
present
hospital.
Detection
complex
systemic
using
long
go.
Saliva-based
gaining
attention
among
due
their
non-invasive
collection
ability
periodontal
identify
diseases.
possibility
saliva-based
diagnostic
gained
much
publicity,
companies
sending
home
kits
for
ancestry
prediction.
testing
covid
19
revealed
effective
clinical
use
relevance
economic
collection.
Based
on
universal
biomarkers,
booming
arena.
Lots
available,
but
it
still
poses
challenges
limitations
as
POC
devices.
This
review
paper
talks
about
saliva
its
usefulness
biosensor.
Also,
recommendations
considered
enable
possible
tool.
Disease Markers,
Journal Year:
2018,
Volume and Issue:
2018, P. 1 - 22
Published: Nov. 7, 2018
The
Global
Burden
of
Oral
Diseases
affects
3.5
billion
people
worldwide,
representing
the
number
affected
by
burden
untreated
dental
caries,
severe
periodontal
disease,
and
edentulism.
Thus,
much
more
efforts
in
terms
diagnostics
treatments
must
be
provided
fight
these
outcomes.
In
this
sense,
recently,
study
saliva
as
biological
matrix
has
been
identified
a
new
landmark
initiative
search
novel
useful
biomarkers
to
prevent
diagnose
conditions.
Specifically,
is
rich
reservoir
different
proteins
peptides
accessible
due
recent
advances
molecular
biology
specially
targeted
unbiased
proteomics
technologies.
Nonetheless,
emerging
barriers
are
an
obstacle
salivary
proteome
effective
way.
This
review
aims
at
giving
overall
perspective
several
oral
diseases
means
approaches.
