The Beclin 1 network regulates autophagy and apoptosis

Cell Death and Differentiation, Journal Year: 2011, Volume and Issue: 18(4), P. 571 - 580

Published: Feb. 11, 2011

Language: Английский

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Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice

The Journal of Cell Biology, Journal Year: 2005, Volume and Issue: 169(3), P. 425 - 434

Published: May 2, 2005

Autophagy is a membrane-trafficking mechanism that delivers cytoplasmic constituents into the lysosome/vacuole for bulk protein degradation. This involved in preservation of nutrients under starvation condition as well normal turnover component. Aberrant autophagy has been reported several neurodegenerative disorders, hepatitis, and myopathies. Here, we generated conditional knockout mice Atg7, an essential gene yeast. Atg7 was ATG conjugation systems autophagosome formation, amino acid supply neonates, starvation-induced degradation proteins organelles mice. Furthermore, deficiency led to multiple cellular abnormalities, such appearance concentric membranous structure deformed mitochondria, accumulation ubiquitin-positive aggregates. Our results indicate important role response quality control quiescent cells.

Language: Английский

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The amyloid state and its association with protein misfolding diseases

Nature Reviews Molecular Cell Biology, Journal Year: 2014, Volume and Issue: 15(6), P. 384 - 396

Published: May 23, 2014

Language: Английский

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Fluorescence Lifetime Measurements and Biological Imaging

Chemical Reviews, Journal Year: 2010, Volume and Issue: 110(5), P. 2641 - 2684

Published: March 31, 2010

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTFluorescence Lifetime Measurements and Biological ImagingMikhail Y. Berezin* Samuel Achilefu*View Author Information Department of Radiology, Washington University School Medicine, 4525 Scott Ave, St. Louis, USA* To whom correspondence should be addressed. Tel. 314-747-0701 (M.Y.B.); 314-362-8599 (S.A.). Fax: 314-747-5191. E-mail: [email protected] (S.A.).Cite this: Chem. Rev. 2010, 110, 5, 2641–2684Publication Date (Web):March 31, 2010Publication History Received19 October 2009Published online31 March 2010Published inissue 12 May 2010https://pubs.acs.org/doi/10.1021/cr900343zhttps://doi.org/10.1021/cr900343zreview-articleACS PublicationsCopyright © 2010 American Chemical SocietyRequest reuse permissionsArticle Views41161Altmetric-Citations1762LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated to reflect usage leading up last few days.Citations number other articles citing this article, calculated by Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence for given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Biological imaging,Dyes pigments,Fluorescence,Fluorescence imaging,Fluorophores Get e-Alerts

Language: Английский

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Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism

Cellular and Molecular Life Sciences, Journal Year: 2016, Volume and Issue: 73(17), P. 3221 - 3247

Published: April 21, 2016

The multifunctional regulator nuclear factor erythroid 2-related (Nrf2) is considered not only as a cytoprotective regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it also powerful modulator species longevity. vertebrate Nrf2 belongs to Cap 'n' Collar (Cnc) bZIP family transcription factors shares high homology with SKN-1 from Caenorhabditis elegans or CncC found in Drosophila melanogaster. major characteristics are some extent mimicked by Nrf2-dependent their proteins including heme oxygenase-1 (HO-1), which besides removing toxic heme, produces biliverdin, iron ions carbon monoxide. HO-1 products exert beneficial effects through protection against oxidative injury, regulation apoptosis, modulation inflammation well contribution angiogenesis. On other hand, disturbances proper level associated pathogenesis age-dependent disorders, neurodegeneration, cancer macular degeneration. This review summarizes our knowledge about across different phyla suggesting conservative role stress-protective anti-aging factors.

Language: Английский

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