Circulating testican-2 is a podocyte-derived marker of kidney health

Proceedings of the National Academy of Sciences, Journal Year: 2020, Volume and Issue: 117(40), P. 25026 - 25035

Published: Sept. 21, 2020

Significance All existing blood biomarkers of kidney function such as creatinine and cystatin C undergo renal clearance are thus inversely correlated with estimated glomerular filtrate rate (eGFR). Using a proteomic approach, we highlight the release testican-2 among individuals undergoing invasive catheterization show that higher levels associated eGFR slower subsequent decline in two large racially diverse cohorts. In conjunction microscopy single-cell RNA sequencing human samples, these studies advance concept protein released by podocyte can provide insight into kidney’s health prognosis. Cell-based also raise possibility this has functional effects on neighboring endothelial cells.

Language: Английский

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Metabolomics of Arterial Stiffness

Metabolites, Journal Year: 2022, Volume and Issue: 12(5), P. 370 - 370

Published: April 20, 2022

Arterial stiffness (AS) is one of the earliest detectable signs structural and functional alterations vessel wall an independent predictor cardiovascular events death. The emerging field metabolomics can be utilized to detect a wide spectrum intermediates products metabolism in body fluids that involved pathogenesis AS. Research over past decade has reinforced this idea by linking AS circulating acylcarnitines, glycerophospholipids, sphingolipids, amino acids, among other metabolite species. Some these metabolites influence through traditional risk factors (e.g., high blood pressure, cholesterol, diabetes, smoking), while others seem act independently both known unknown pathophysiological mechanisms. We propose term ‘arteriometabolomics’ indicate research applies methods study approach potential allow more personalized stratification, disease monitoring, treatment selection. One its major goals uncover causal metabolic pathways Such could represent valuable targets vascular ageing.

Language: Английский

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Serum amino acid alterations in hyperuricemia: potential targets for renal disease prevention

Amino Acids, Journal Year: 2025, Volume and Issue: 57(1)

Published: Feb. 18, 2025

Observational studies have linked uric acid (UA) levels and kidney disease to amino homeostasis, but the causal relationship is unclear. This study aims determine if elevated UA affects whether acids mediate this relationship, focusing on links between UA, circulating acids, disease. Methods: utilized Uox-KO mice as a hyperuricemia model, assessed renal injury through blood biochemistry pathology, analyzed serum changes via targeted acidomics, employed Mendelian randomization investigate acid, Results: Hyperuricemia significantly higher impairment markers, with histopathological analysis showing extensive tissue damage. Changes in balance were found mice's serum, key metabolites like alanine, isoleucine, leucine, aspartic cysteine, glutamate, glycine potentially influencing pathophysiology. Genetically predicted was positively correlated chronic failure (CRF) urea nitrogen(BUN) negatively cystatin C (eGFRcys) creatinine (eGFRcrea). Alanine (Ala) mediated effect of CRF BUN risk, accounting for 4.5% UA-CRF 14.4% UA-BUN association. Conclusion: In mice, undergo metabolic changes. are BUN, eGFRcys eGFRcrea. Ala mediates UA's indicating could be target preventing diseases caused by hyperuricemia.

Language: Английский

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Metabolites Mediate the Causal Associations Between Gut Microbiota and Chronic Kidney Disease: A Mendelian Randomization Study and Therapeutical Strategy from Traditional Chinese Medicine Perspective

Integrative Medicine in Nephrology and Andrology, Journal Year: 2025, Volume and Issue: 12(2)

Published: April 7, 2025

Background: In chronic kidney disease (CKD), patients often suffer from intestinal barrier damage and gut microbiota disorders, characterized by reduced beneficial bacteria, increased harmful production of neurotoxins that worsen damage. While associations between microbiota, plasma metabolites, CKD have been observed, the causal relationships remain unclear may be confounded other factors. To address this, we used Mendelian randomization (MR) to investigate effects metabolites on CKD. Simultaneously, explored strategy Traditional Chinese medicine regulate influence mediated serum Methods: A two-sample MR study was conducted evaluate potential connections among susceptibility. Gut data were obtained genome-wide association studies (GWASs) microbiome composition Dutch Microbiome Project. procured FinnGen biobank analysis, while comprehensive GWAS summary statistics for derived NHGRI-EBI Catalog. Fluctuations in with evaluated using weighted mode method. Additionally, pleiotropic heterogeneity analyses assess reliability findings. Results: Twelve taxonomic bacterial pathways sixteen found significantly associated analysis revealed four relationships. Mediation showed arachidonoylcholine levels relationship enterobacterial common antigen biosynthesis pathway (ECASYN.PWY) risk CKD, a mediation proportion 24.8%. X-12007 aspartate superpathway (PWY0.781) 15.6%. N-acetyl-2-aminooctanoate tetrapyrrole II glycine (PWY.5189) 7.7%. X-22776 pyrimidine deoxyribonucleotides de novo Biosynthesis (PWY.7211) 23.8%. Conclusion: The current provides evidence supporting specific taxa pathways, metabolite, These findings offer novel perspectives future research development treatment prevention strategies as well scientific basis traditional intervention microbiota.

Language: Английский

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1,5-Anhydroglucitol predicts CKD progression in macroalbuminuric diabetic kidney disease: results from non-targeted metabolomics

Metabolomics, Journal Year: 2018, Volume and Issue: 14(4)

Published: Feb. 27, 2018

Language: Английский

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