Shorter androgen receptor polyQ alleles protect against life-threatening COVID-19 disease in European males

EBioMedicine, Journal Year: 2021, Volume and Issue: 65, P. 103246 - 103246

Published: Feb. 26, 2021

Language: Английский

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Andrological effects of SARS-Cov-2 infection: a systematic review and meta-analysis

Journal of Endocrinological Investigation, Journal Year: 2022, Volume and Issue: 45(12), P. 2207 - 2219

Published: May 9, 2022

The short- and long-term andrological effects of coronavirus disease 2019 (COVID-19) have not been clarified. Our aim is to evaluate the available evidence regarding possible consequences COVID-19 either on seminal or hormonal parameters. safety vaccines in terms sperm quality was also investigated.All prospective retrospective observational studies reporting information severe acute respiratory syndrome 2 (SARS-Cov-2) mRNA semen male genitalia tract detection (n = 19), as well those data analysis 5) parameters 11) infected/recovered patients without any arbitrary restriction were included.Out 204 retrieved articles, 35 considered, including 2092 1138 controls with a mean age 44.1 ± 12.6 years, follow-up 24.3 18.9 days. SARS-CoV-2 can be localized tracts during phase disease. result short-term impaired T production. Available cannot clarify effects. Low observed associated an increased risk being admitted Intensive Care Unit death. two showed that use does affect quality.The results our clearly suggest each patient recovering from should monitored rule out abnormalities. specific contribution reduced levels infection needs better

Language: Английский

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Excess diabetes mellitus-related deaths during the COVID-19 pandemic in the United States

EClinicalMedicine, Journal Year: 2022, Volume and Issue: 54, P. 101671 - 101671

Published: Sept. 23, 2022

Diabetes mellitus (DM) is a critical risk factor for severe SARS-CoV-2 infection, and infection contributes to worsening glycemic control. The COVID-19 pandemic profoundly disrupted the delivery of care patients with diabetes. We aimed determine trend DM-related deaths during pandemic.In this serial population-based study between January 1, 2006 December 31, 2021, mortality data decedents aged ≥25 years from National Vital Statistics System dataset was analyzed. Decedents DM as underlying or contributing cause death on certificate were defined deaths. Excess estimated by comparing observed versus expected age-standardized rates derived 2006-2019 linear polynomial regression models. trends quantified joinpoint analysis. Subgroup analyses performed age, sex, race/ethnicity, state.Among 4·25 million 2006-2021, there significant surge more than 30% in pandemic, 106·8 (per 100,000 persons) 2019 144·1 2020 148·3 2021. Adults 25-44 had most pronounced rise mortality. Widened racial/ethnic disparity observed, Hispanics demonstrating highest excess (67·5%; 95% CI 60·9-74·7%), almost three times that non-Hispanic whites (23·9%; 21·2-26·7%).The United States saw an increase pandemic. disproportionate young adults widened warrant urgent preventative interventions diverse stakeholders.National Natural Science Foundation China.

Language: Английский

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Testosterone Replacement Therapy and Risk of COVID-19 and Effect of COVID-19 on Testosterone's Treatment Effect

Journal of the Endocrine Society, Journal Year: 2025, Volume and Issue: 9(3)

Published: Jan. 7, 2025

Abstract Context Whether circulating testosterone, dihydrotestosterone, and estradiol levels or testosterone replacement therapy (TRT) affects the risk of COVID-19 whether response to TRT remains unknown. Objective The study evaluated baseline are associated with developing treatment TRT. Methods Among 5204 men, aged 45 80 years, hypogonadism in TRAVERSE trial, 379 developed COVID-19. We compared on-treatment hormone levels, safety efficacy participants without diagnosis. Results Neither nor estradiol, dihydrotestosterone prior differed significantly between men Incidence was similar randomized placebo groups (3-year Kaplan-Meier incidence 8.0% 8.6% group, P = .823). Incidences COVID-19-related hospitalizations (38.5% vs 32.8%, .222) deaths (12.8% 8.9%, .247) were groups. Changes hypogonadal symptoms, libido, energy, hemoglobin/hematocrit attenuated testosterone-treated who major adverse cardiovascular events, venous thromboembolism, acute kidney injury those diagnosis without. Conclusion In disease (CVD) increased CVD, pre-COVID-19 did not. not affect

Language: Английский

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Sex Disparities and Neutralizing-Antibody Durability to SARS-CoV-2 Infection in Convalescent Individuals

mSphere, Journal Year: 2021, Volume and Issue: 6(4)

Published: Aug. 25, 2021

In this study, we found that neutralizing antibody responses in COVID-19-convalescent individuals vary magnitude but are durable and correlate well with receptor binding domain (RBD) Ig levels compared to other SARS-CoV-2 antigen responses. our cohort, higher titers independently significantly associated male sex female sex.

Language: Английский

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Associations between COVID-19 infection and sex steroid hormones

Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13

Published: Oct. 11, 2022

Aims Coronavirus disease 2019 (COVID-19) is caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and within a few months of the first outbreak, it was declared global pandemic WHO. The lethal virus SARS-CoV-2 transmitted through droplets enters host cells angiotensin-converting enzyme (ACE-2) receptors. ACE-2 receptors are highly expressed in many tissues, including testes. Therefore, objective this study to summarize available literature regarding correlation between sex hormone levels COVID-19. Methods PubMed, Web Science, Embase, Cochrane Library databases were reviewed systematically August 2022 for studies comparing different patient groups: COVID-19 versus no COVID-19, more less non-survivors survivors. Various types clinical research reporting levels, free testosterone (FT), luteinizing (LH), follicle-stimulating (FSH), 17β-oestradiol (E ), oestradiol-to-testosterone ratio /T), prolactin (PRL), hormone-binding globulin (SHBG), included. Random- or fixed-effects models used calculate weighted mean differences (WMDs) 95% confidence intervals (CIs). Heterogeneity among assessed I index, data analyses performed using meta-analysis Stata version 12.0. Results Twenty-two articles that included 3369 patients ultimately meta-analysis. According analysis studies, had significantly low T/LH, FSH/LH, SHBG high LH, E /T, but their FT, FSH, PRL, , progesterone not affected. Publication bias found according funnel plots Egger’s regression Begg’s rank tests. Conclusion Low serum /T may increase risk Additionally, greater severity higher probability increases decreases levels. have unfavourable effects on gonadal functions, which should be taken seriously clinicians. Routine monitoring might help clinicians evaluate

Language: Английский

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SARS-CoV-2 and male infertility: from short- to long-term impacts

Journal of Endocrinological Investigation, Journal Year: 2023, Volume and Issue: 46(8), P. 1491 - 1507

Published: March 14, 2023

Language: Английский

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Sex differences in airway disease: estrogen and airway surface liquid dynamics

Biology of Sex Differences, Journal Year: 2024, Volume and Issue: 15(1)

Published: July 18, 2024

Abstract Biological sex differences exist for many airway diseases in which females have either worse or better health outcomes. Inflammatory such as cystic fibrosis (CF) and asthma display a clear male advantage post-puberty while female benefit is observed during the pre-puberty years. The influence of menstrual cycle stage pregnancy on frequency severity pulmonary exacerbations CF point to role steroid hormones, particularly estrogen, underpinning biological these diseases. There are ways by estrogen may aggravate involving disturbances surface liquid (ASL) dynamics, inappropriate hyper-immune allergenic responses, well exacerbation pathogen virulence. deleterious effect function contrasts with characterised edema pneumonia, acute respiratory distress syndrome (ARDS) COVID-19. Airway hypersecretion alveolar flooding hallmarks ARDS COVID-19, contribute morbidity mortality severe forms ASL dynamics encompasses intrinsic features thin lining fluid covering epithelium regulate mucociliary clearance (ciliary beat, height, volume, pH, viscosity, mucins, channel activating proteases) addition innate defence mechanisms (pathogen virulence, cytokines, defensins, specialised pro-resolution lipid mediators, metabolism). Estrogen regulation contributing CF, COVID-19 major focus this review. Graphical

Language: Английский

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SARS-CoV-2 Variants Detection Using TaqMan SARS-CoV-2 Mutation Panel Molecular Genotyping Assays

Infection and Drug Resistance, Journal Year: 2021, Volume and Issue: Volume 14, P. 4471 - 4479

Published: Oct. 1, 2021

Purpose: For rapid detection and tracking of SARS-CoV-2, a simple screening method alternative to laborious expensive sequencing is highly desirable. Here, we evaluated performance characteristics TaqMan SARS-CoV-2 mutation panel genotyping molecular assay for most common reported variants using specific RT-PCR assays targeting single nucleotide polymorphisms (SNP). Patients Methods: A total 150 positive samples from March July were included this study. In addition, five controls comprised synthetic RNA B.1.1.7_601443, B.1.351_678597, P.1_792683, B.1.617.1_1662307 MN908947.3-Wuhan-hu-1 Twist bioscience B.1.1.7 (England/204820464/2020) B.1.351 (South Africa/KRISP-K005325/2020) Zeptometrix, NY, USA used validation. Total specimens was extracted Omega Bio-Tek Mag-Bind Viral Xpress Extraction Kit tested known SARS-CoV2 ThermoFisher on the QuantStudio 12K Flex. Nine representative have been compared with sequencing. Data analyzed by genotype calling QuantStudio™ design analysis software v 2.5 module. Results: All validation in triplicate repeated singlet three different days all matched as expected. Out specimens, 69 (46%) B.1.617.2, 49 (32.7%) B.1.1.7, P.1 P.2 4 (2.7%) each B.1.427/B.1429 2 (1.3%) each. Three (2%) B.1.526, 17 (11.3%) D614G. Genotyping results present study showing B.1.526 their genes concordant results. Conclusion: Our indicates that detect differentiate published B.1.617.2 (Delta), (Alpha), (Iota), (Beta), (Gamma), (Zeta), B.1.617.1 (Kappa) B.1.427/B.1.429 (Epsilon) can be surveillance epidemic control prevention. Keywords: variants, delta, alpha,

Language: Английский

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Generalizable Long COVID Subtypes: Findings from the NIH N3C and RECOVER Programs

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: May 25, 2022

Abstract Accurate stratification of patients with post-acute sequelae SARS-CoV-2 infection (PASC, or long COVID) would allow precision clinical management strategies. However, the natural history COVID is incompletely understood and characterized by an extremely wide range manifestations that are difficult to analyze computationally. In addition, generalizability machine learning classification COVID-19 outcomes has rarely been tested. We present a method for computationally modeling PASC phenotype data based on electronic healthcare records (EHRs) assessing pairwise phenotypic similarity between using semantic similarity. Our approach defines nonlinear function maps from feature space abnormalities matrix patient can be clustered unsupervised procedures. Using k-means clustering this matrix, we found six distinct clusters patients, each profiles abnormalities. There was significant association cluster membership pre-existing conditions measures severity during acute COVID-19. Two were associated severe displayed increased mortality. assigned new other centers one basis maximum original patients. show identified generalizable across different hospital systems mortality rate consistently observed in two clusters. Semantic provide foundation assigning stratified subgroups therapy studies PASC.

Language: Английский

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