Clinical Characterization of Demoralization

Psychotherapy and Psychosomatics, Journal Year: 2023, Volume and Issue: 92(3), P. 139 - 147

Published: Jan. 1, 2023

Language: Английский

---

Review of Major Social Determinants of Health in Schizophrenia-Spectrum Psychotic Disorders: III. Biology

Schizophrenia Bulletin, Journal Year: 2023, Volume and Issue: 49(4), P. 867 - 880

Published: April 6, 2023

Social determinants of health (SDoHs) are nonmedical factors that significantly impact and longevity. We found no published reviews on the biology SDoHs in schizophrenia-spectrum psychotic disorders (SSPD).

Language: Английский

---

Out of touch? How trauma shapes the experience of social touch – Neural and endocrine pathways

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 159, P. 105595 - 105595

Published: Feb. 17, 2024

Trauma can shape the way an individual experiences world and interacts with other people. Touch is a key component of social interactions, but surprisingly little known how trauma exposure influences processing touch. In this review, we examine possible neurobiological pathways through which influence touch lead to aversion avoidance in trauma-exposed individuals. Emerging evidence indicates that may affect sensory thresholds by modulating activity primary cortex posterior insula. Disturbances multisensory integration oxytocin reactivity combined diminished reward-related anxiolytic responses induce bias towards negative appraisal contexts. Furthermore, hippocampus deactivation during reflect dissociative state. These changes depend not only on type severity also features We hypothesise disrupted impair interactions confer elevated risk for future stress-related disorders.

Language: Английский

---

Behavioral and Neural Dissociation of Social Anxiety and Loneliness

Journal of Neuroscience, Journal Year: 2022, Volume and Issue: 42(12), P. 2570 - 2583

Published: Feb. 14, 2022

Loneliness is a public health concern with detrimental effects on physical and mental well-being. Given phenotypical overlaps between loneliness social anxiety (SA), cognitive-behavioral interventions targeting SA might be adopted to reduce loneliness. However, whether share the same underlying neurocognitive mechanisms still an elusive question. The current study aimed at investigating what extent known behavioral neural correlates of avoidance in are evident We used prestratified approach involving 42 (21 females) participants high (HL) 40 (20 low (LL) scores. During fMRI, completed gambling task measure subjective value engaging situations responses feedback. Univariate multivariate analyses data replicated effects. although HL showed increased SA, was associated response pattern clearly distinct from SA. Specifically, contrary expectations based differences, Bayesian revealed moderate evidence for equal values comparable amygdala decision-making striatal positive feedback both groups. Moreover, while explorative reduced pleasantness ratings, activity, decreased striatal-hippocampal connectivity negative computer participants, these were diminished Our findings suggest that, unlike not withdrawal interactions. Thus, established should adjusted when

Language: Английский

---

Fear of missing out (FOMO) associates with reduced cortical thickness in core regions of the posterior default mode network and higher levels of problematic smartphone and social media use

Addictive Behaviors, Journal Year: 2023, Volume and Issue: 143, P. 107709 - 107709

Published: March 25, 2023

Language: Английский

---

Oxytocin-Augmented Modular-Based Group Intervention for Loneliness: A Proof-Of-Concept Randomized Controlled Trial

Psychotherapy and Psychosomatics, Journal Year: 2024, Volume and Issue: 93(3), P. 169 - 180

Published: Jan. 1, 2024

Loneliness poses a significant health problem and existing psychological interventions have shown only limited positive effects on loneliness. Based preliminary evidence for impaired oxytocin signaling in trait-like loneliness, the current proof-of-concept study used randomized, double-blind, placebo-controlled design to probe intranasal (OT) as an adjunct short-term modular-based group intervention individuals suffering from high loneliness (HL, UCLA Scale ≥55).

Language: Английский

---

The neurocognitive impact of loneliness and social networks on social adaptation

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: July 25, 2023

Social adaptation arises from the interaction between individual and social environment. However, little empirical evidence exists regarding relationship contact adaptation. We propose that loneliness networks are key factors explaining Sixty-four healthy subjects with no history of psychiatric conditions participated in this study. All participants completed self-report questionnaires about loneliness, network, On a separate day, underwent resting state fMRI recording session. A hierarchical regression model on data revealed network were negatively positively associated Functional connectivity (FC) analysis showed was decreased FC fronto-amygdalar fronto-parietal regions. In contrast, fronto-temporo-parietal network. Finally, an integrative path examined combined effects behavioral brain predictors The mediated Further, loneliness-related abnormal (previously shown to be difficulties cognitive control, emotion regulation, sociocognitive processes) emerged as strongest predictor poor Findings offer insights into indicators highlight role buffer against maladaptive loneliness. These findings can inform interventions aimed at minimizing promoting especially relevant due high prevalence around globe. also serve study since they provide potential neurocognitive could influence

Language: Английский

---

Interplay of Neighborhood and Psychosocial Factors in Predicting Trajectories of Allostatic Load Among Latinx Adults in the United States

Hispanic Journal of Behavioral Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Research highlights the independent roles of neighborhood and psychosocial risk protective factors for accelerated physiological aging. However, combined role allostatic load among Latinx adults in U.S. remains unclear. Informed by Health Disparities Framework, study aims are to: (1) examine direct associations between (cohesion disorder) (loneliness) factors, respectively, trajectories; (2) determine whether family social support moderates association loneliness trajectories. Data ages ≥50 ( n = 319) from Retirement Study (waves 2006–2016). Linear mixed models estimated baseline rate change load, adjusting sociodemographics. Loneliness was positively associated with load. This persisted when we considered factors. Family moderated slope. As features, loneliness, dysregulation each worse cognitive outcomes, findings underscore dysregulation, thereby promoting resilience.

Language: Английский

---

Effects of a 16-week dance intervention on loneliness and self-esteem in left behind children: a randomised controlled trial

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 25, 2025

Loneliness and low self-esteem are among the more prominent mental health problems left-behind children, but most of current research stays in cross-sectional surveys, with fewer studies proposing specific solutions. In addition, although effective impact dance interventions on loneliness has been demonstrated, group children remains under-explored. Therefore, this study validated effectiveness a intervention through 16-week randomised controlled trial. Stratified sampling was used to select one primary school from each 14 cities Hunan Province, maximum 100 recruited school. Independent researchers SPSS 29.0 randomly assign eligible 1270 participants Experimental (n = 635) Control 1:1 ratio. The performed 45 min moderate-intensity training five times week. maintained their original living conditions. Participants were measured three using Children's Scale Rosenberg's Self-Esteem Scale: baseline (T0), after 8 weeks (T1), post-intervention (16 weeks, T2). Linear mixed-effects models for repeated measures test effects time, time × interactions. (a) average age 1261 10 years (SD 3.52), high levels (42.48 ± 12.04) (26.75 6.39). (b) There significant negative correlation between LBC (p < 0.001, r − 0.390). (c) After intervention, LBC's significantly decreased [F (2, 1258) 74.516, ηp2 0.106, p 0.001] increased 73.64, 0.104, 0.001]. A is an strategy improve LBC. Given acceptability practicality it could be included programme

Language: Английский

---

Major depressive disorder on a neuromorphic continuum

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 11, 2025

The heterogeneity of major depressive disorder (MDD) has hindered clinical translation and neuromarker identification. Biotyping facilitates solving the problems heterogeneity, by dissecting MDD patients into discrete subgroups. However, interindividual variations suggest that depression may be conceptualized as a "continuum," rather than "category." We use Bayesian model to decompose structural MRI features from multisite cross-sectional cohort three latent disease factors (spatial pattern) continuum factor compositions (individual expression). are associated with distinct neurotransmitter receptors/transporters obtained open PET sources. Increases cortical thickness in sensory decreases orbitofrontal cortices (Factor 1) associate norepinephrine 5-HT2A density, cingulo-opercular network subcortex 2) 5-HTT increases social affective brain systems 3) relate density. Disease patterns can also used predict symptom improvement longitudinal cohort. Moreover, individual expressions stable over time cohort, differentially expressed controls transdiagnostic Collectively, our data-driven reveal organize along continuous dimensions affect sets regions. Li et al. identify abnormalities using an unsupervised machine learning technique, quantify their expression level for each patient.

Language: Английский

---