Archives of Osteoporosis, Journal Year: 2024, Volume and Issue: 19(1)
Published: Oct. 4, 2024
Language: Английский
Maturitas, Journal Year: 2024, Volume and Issue: 185, P. 107975 - 107975
Published: March 21, 2024
Language: Английский
Citations
4
BMC Endocrine Disorders, Journal Year: 2025, Volume and Issue: 25(1)
Published: Jan. 26, 2025
The Weight-adjusted-waist index (WWI) has emerged as a predictive factor for range of metabolic disorders. To date, the value WWI in relation to sarcopenia individuals with diabetics not been extensively explored. This study aims investigate impact on prevalence among patients type 2 diabetes mellitus (T2DM). In this study, we enrolled 417 T2DM from Second Affiliated Hospital and Yuying Children's Wenzhou Medical University between Dec. 2023 Apr. 2024. relationship was evaluated using multivariate logistic regression, subgroup analysis, restricted cubic spline (RCS) receiver operating characteristic (ROC) curve analysis. Among T2DM, 76 (18.22%) were identified having sarcopenia. across quartile categories, first fourth quartile, 8.65%, 8.57%, 20.19% 8.65% respectively. Multivariate regression analysis revealed that, after adjusting covariates, higher an independent risk male (OR = 1.836, 95% CI: 1.216-2.772, P 0.004). association observed female patients. Subgroup further stronger correlation HbA1c levels. males, RCS demonstrated non-linear positive correlation, inflection point at 10.42 cm/√kg. Finally, area under ROC (AUC) 0.612. emerges robust T2DM. may serve accessible cost-effective tool identify diabetes.
Language: Английский
Citations
0
IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 19, 2025
Sarcopenia refers to the rapid loss of skeletal muscle mass and strength, which can result in serious consequences such as falls, fractures, a higher risk mortality. The prevalence sarcopenia is observed be twice high individuals with type 2 diabetes mellitus. Notably, there bidirectional relationship between mellitus, where each condit‑‑ion exacerbate progression other. Overlapping pathophysiological mechanisms, insulin resistance, inflammation, oxidative stress, accumulation advanced glycation end products, mitochondrial dysfunction, myosteatosis, aging process itself contribute development both conditions. A few treatments, myostatin antagonists, testosterone supplementation, selective androgen receptor modulators have been explored, but many remain experimental or clinical trial stages. cornerstone management involves nutritional intervention foods rich protein, essential amino acids, vitamin D, omega-3 fatty acids. Additionally, incorporating regular physical activity, particularly resistance exercises, minimizing sedentary behavior are key components for sarcopenia.
Language: Английский
Citations
0
OBM Geriatrics, Journal Year: 2025, Volume and Issue: 09(01), P. 1 - 23
Published: Feb. 20, 2025
Sarcopenia is more common in persons with type 2 diabetes mellitus (T2DM) than without diabetes. There overlap of some pathophysiologic features sarcopenia and T2DM. In addition, the risk for associated complications T2DM including renal disease, cardiovascular disease neuropathy. Glycemic control may have benefits on sarcopenia. The specific effects glucose lowering agents suggest that metformin, insulin, thiazolidinediones GLP1 receptor agonists favorable while SGLT2 inhibitors an adverse effect. However, RA’s been outcomes increased heart failure. Thus risk/benefit ratio overall key to selection agents. Nutrition guidelines generally align recommendations Data aerobic resistance exercise patients very limited, but data a benefit exercises.
Language: Английский
Citations
0
BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)
Published: March 29, 2025
Gallstones are a common disease that imposes significant burden on public health resources. Sarcopenia is an age-related condition characterized by decline in muscle mass, strength, and function. However, its relationship with gallstones remains unclear. This cross-sectional study included 2,167 US adults from the National Health Nutrition Examination Survey. We used multivariable logistic regression models restricted cubic spline to assess between sarcopenia gallstones. Additionally, subgroup analyses propensity score matching (PSM) were conducted account for potential confounding factors. found negative association index prevalence of (OR: 0.253, 95% CI: 0.132-0.471, P < 0.001). In Model 4, which integrated all covariates, was associated approximately 100% increased compared non-sarcopenia patients 1.995, 1.340-2.948, The results PSM also confirmed 1.982, 1.217-3.285, = 0.007). Notably, this more pronounced subgroups including females, non-Hispanic whites, married individuals, higher education level. summary, our findings suggest positive adults. suggests we should increase emphasis gallstone screening patients. finding needs be validated through further large-scale prospective studies.
Language: Английский
Citations
0
Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13
Published: April 3, 2025
People with diabetes mellitus (DM) have a significantly increased risk of sarcopenia. A cross-sectional analysis was performed using nationally representative data to evaluate possible sarcopenia in middle-aged and older adults mellitus, develop validate prediction model suitable for the Chinese community. Data from China Health Retirement Longitudinal Study (CHARLS), which focuses on people 45 years age or older, served as basis model. CHARLS 2015 participants were used study, examined 53 factors. In order guarantee reliability, study split into two groups at random: 70% training 30% validation. Ten-fold cross-validation Least Absolute Shrinkage Selection Operator (LASSO) regression analyses determine best predictors The factors associated DM researched logistic models. Nomogram constructed predictive performance assessed area under curve (AUC), calibration curves decision (DCA). total 2,131 database collected passed final analysis, prevalence 28.9% (616/2131). Eight subsequently chosen models by LASSO regression: age, residence, body mass index, diastolic blood pressure, cognitive function, activities daily living, peak expiratory flow hemoglobin. These nomogram model, showed good accuracy agreement. AUC values validation sets 0.867 (95%CI: 0.847~0.887) 0.849 0.816~0.883). Calibration DCA indicated that exhibited performance. this can be probability adult DM, is helpful early identification intervention high-risk groups.
Language: Английский
Citations
0
Endocrinology Diabetes & Metabolism, Journal Year: 2025, Volume and Issue: 8(3)
Published: April 8, 2025
ABSTRACT Introduction While type 2 diabetes (T2DM) has become a major health issue in the North American and Caribbean region, effects of weight change on incident T2DM, conditional either initial or attained weight, are poorly addressed. Therefore, we aimed to assess impact 3‐year T2DM over 6 years among US individuals. Methods A total 8377 participants aged 45–64 (4601 women), free cancer at baseline from Atherosclerosis Risk Communities (ARIC) study were included. Weight measurements taken (visit 1, 1987–89) approximately 3 later 2, 1990–92). Participants categorised based their ratio into ≥ 5% loss, stable (±5%), gain. Cox proportional hazards models, adjusting for known risk factors, used estimate hazard ratios (HRs) 95% confidence intervals (CIs) with (±5%) as reference category. Results During median follow‐up period years, classified three categories: 361 persons remained 47 135 In multivariable analysis, after adjustment gain loss significantly associated higher [HR (95% CI): 1.68 (1.36–2.06), p ‐value < 0.0001] lower [0.73 (0.53–1.00), = 0.05] risks respectively. When adjusted significant factor [1.51 (1.21–1.88)]; however, lost statistical significance [0.84 (0.60–1.17), 0.31]. Conclusions We found robust association between T2DM; beneficial was attenuated considering weight.
Language: Английский
Citations
0
Reviews in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 26(4)
Published: April 24, 2025
The high prevalence of sarcopenia among hypertensive adults is a global health issue. Growing literature demonstrates that antioxidant diet can protect against sarcopenia. However, little attention has been paid to the association between dietary composite intake and in hypertension. To investigate potential efficacy index (CDAI) on adults. This study included 6995 from National Health Nutrition Examination Survey (NHANES) 2001-2006 2013-2018, with 3212 (45.92%) females 3783 (54.08%) males. Appendicular lean mass (ALM) were assessed by dual-energy X-ray absorptiometry (DEXA). All participating NHANES eligible participate interviews, average six antioxidants over two days was used calculate CDAI. Logistic regression conducted determine odds ratios (ORs) 95% confidence intervals (CIs). Subgroup analyses restricted cubic spline (RCS) regressions additionally utilized. mean age 48.47 ± 0.27 years old, 1059 (15.14%) considered have highest quartile had 61% decreased risk (OR = 0.39, CI: 0.25, 0.60) compared lowest RCS revealed linear CDAI ALM. demonstrated more pronounced inverse correlation females. In summary, our results indicated reverse These findings highlighted beneficial role an antioxidant-rich prevention provided valid method for managing
Language: Английский
Citations
0
The Lancet Diabetes & Endocrinology, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Citations
0
Experimental Gerontology, Journal Year: 2025, Volume and Issue: 206, P. 112775 - 112775
Published: May 7, 2025
Nutritional status and levels of oxidative stress may be modifiable risk factors for the development sarcopenia. The Oxidative Balance Score (OBS) is a comprehensive measure balance in diet life exposures. We conducted cross-sectional study to investigate association between OBS sarcopenia US adults. Based on 2011-2018 National Health Nutrition Examination Survey (NHANES), this included 3084 participants. Weighted logistic regression analysis restricted cubic spline (RCS) were used assess sarcopenia, as well gender differences association. are negatively associated (OR = 0.951, 0.919-0.983, p 0.004). Compared with lowest quartile OBS, highest was significantly 0.431, 0.202-0.917, trend 0.01). Both dietary lifestyle 0.963, 0.930-0.997, 0.032; OR 0.634, 0.562-0.715, < 0.001). In subgroup analysis, significant negative observed women 0.916, 0.862-0.973, 0.005), while not men. RCS showed linear correlation total population female (p nonlinear >0.05, overall <0.05). Higher scores lower prevalence particularly among women. These findings support importance antioxidant-rich diets healthy lifestyles mitigating risk, especially aging populations.
Language: Английский
Citations
0