Medical Hypotheses, Journal Year: 2024, Volume and Issue: unknown, P. 111486 - 111486
Published: Sept. 1, 2024
Language: Английский
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: Jan. 2, 2024
Abstract Clinical efficacy of intranasal administration oxytocin is increasingly explored in autism spectrum disorder, but to date, the biological effects chronic regimes on endogenous oxytocinergic function are largely unknown. Here exploratory assessments from a completed randomized, placebo-controlled trial showed that children with (n = 79, 16 females) receiving for four weeks (12 IU, twice daily) displayed significantly higher salivary levels 24 hours after last nasal spray administration, no longer at four-week follow up session. Regarding receptor gene ( OXTR) epigenetics (DNA-methylation), oxytocin-induced reductions OXTR DNA-methylation were observed, suggesting facilitation expression compared placebo group. Notably, heightened post-treatment associated reduced and improved feelings secure attachment. These findings indicate stimulated system autism.
Language: Английский
Citations
16
Journal of Psychopharmacology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 24, 2025
Intranasal administration of oxytocin is emerging as a potential pharmacological option for mitigating social difficulties and regulating stress in autism spectrum disorder. However, initial single-dose multiple-dose trials showed mixed results, with some demonstrating improvements repetitive behavior others showing no benefit over placebo. This perspective aims to elucidate factors contributing this variability highlight pitfalls opportunities the field. We identified two major factors: design-related elements individual participant characteristics. Pertaining elements, optimal dosing regimens have yet be established, but appear favor moderate intervention durations (i.e., 4-6 weeks) intermittent intermediate 24-32 IU every other day). Also, context seems crucial, enhanced outcomes are mainly observed when paired socially stimulating supporting environment. In addition, more adequate outcome measures established effectively assess oxytocin's impact, including behavioral scales objective biophysiological markers tapping into neurophysiological regulation. Future research should also account differences biological sex, developmental stage cognitive adaptive functioning, incorporate (epi)genetic screening identify responders. Overall, refining study designs personalizing protocols essential optimizing prosocial anxiolytic effect autism.
Language: Английский
Citations
1
Neuroscience, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Language: Английский
Citations
0
Translational Psychiatry, Journal Year: 2025, Volume and Issue: 15(1)
Published: March 28, 2025
Heart rate variability (HRV) monitoring is increasingly applied in the realm of mental disorders; however, it remains a subject controversy. This umbrella review summarizes HRV differences between individuals with disorders and healthy controls (HCs), as well changes before after treatment patients disorders. A literature search was conducted using Medline, PubMed, Embase, Cochrane Database. Meta-analyses on disorders, meta-analyses comparing HCs were included. We computed summary effect size random effects models, along 95% confidence prediction intervals. assessed heterogeneity, p value largest study, excess significance bias, small-study effects. Evidence levels classified convincing, highly suggestive, weak, or not significant. Twenty-one systematic reviews HRV, covering 19 (53 meta-analyses) 8 modalities (18 meta-analyses), included 442 primary studies 34,625. For HCs, evidence suggestive for 7 (13.2%) pooled analyses, indicating decreased dementia, PTSD, somatic symptom functional syndromes, schizophrenia. other including autism spectrum disorder, alcohol use bipolar generalized anxiety insomnia, major depressive weaker below level. effects, 5 analyses (27.8%) had weak evidence, altered antipsychotic treatment, repetitive transcranial magnetic stimulation physiotherapy, psychotherapy. The credibility varied across variables diseases. No two diseases exhibited identical patterns, highlighting potential overall profiles delineating distinct
Language: Английский
Citations
0
Current Opinion in Neurobiology, Journal Year: 2025, Volume and Issue: 92, P. 103015 - 103015
Published: March 30, 2025
Language: Английский
Citations
0
Pilot and Feasibility Studies, Journal Year: 2025, Volume and Issue: 11(1)
Published: April 29, 2025
Language: Английский
Citations
0
Molecular Autism, Journal Year: 2024, Volume and Issue: 15(1)
Published: Dec. 21, 2024
Difficulties with (non-verbal) social communication, including facial expression processing, constitute a hallmark of autism. Intranasal administration oxytocin has been considered potential therapeutic option for improving difficulties in autism, either by enhancing the salience cues or reducing stress and anxiety experienced encounters. We recorded fMRI brain activity while presenting neutral, fearful scrambled faces, to compare neural face processing signature autistic children (n = 58) that matched non-autistic controls 38). Next, group, we implemented this task double-blind, placebo-controlled, multiple-dose clinical trial, evaluate impact four-week repeated (24 IU daily dose) on regions. No significant diagnostic-group differences were identified between versus regard processing. Furthermore, no treatment effects found trial. However, exploratory analyses (uncorrected multiple comparisons) demonstrated decreases left superior temporal sulcus (STS) inferior frontal region compared placebo change-from-baseline group revealed significantly reduced core face-processing network (STS, occipital, posterior fusiform), as well amygdala region. These findings suggest an attenuating effect potentially supporting anxiolytic account oxytocin.
Language: Английский
Citations
1
Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(8), P. 2399 - 2399
Published: April 20, 2024
Background: The primary purpose of this study was to preliminarily examine the effects autonomic nervous system activity on dorsolateral prefrontal cortex. Recent studies have examined approaches modulating using invasive and non-invasive methods, but changes in during cognitive tasks cortex not been fully investigated. preliminary investigation blood oxygen saturation reading induced by vagus nerve stimulation a microcone patch. Methods: A cohort 40 typically developing adults enrolled study. We carefully task two conditions: with without patch stimulation. Results: Significant brain activation cortext due were confirmed. In addition, hierarchical multiple regression analysis revealed specific task-related region Conclusions: It should be recognized that is does immediate clinical applications. However, our results suggest external vagal may affect reading-related regions Further research evaluation are needed understand implications potential applications these findings.
Language: Английский
Citations
0
Medicine Plus, Journal Year: 2024, Volume and Issue: 1(3), P. 100045 - 100045
Published: Aug. 15, 2024
Language: Английский
Citations
0
Medical Hypotheses, Journal Year: 2024, Volume and Issue: unknown, P. 111486 - 111486
Published: Sept. 1, 2024
Language: Английский
Citations
0