Pain research in a petri dish? Advantages and limitations of neuro-glial primary cell cultures from structures of the nociceptive system

Brain Behavior & Immunity - Health, Journal Year: 2024, Volume and Issue: unknown, P. 100854 - 100854

Published: Sept. 1, 2024

How can we learn more about pain without causing in humans or animals? This short review focuses on neuro-glial primary cell cultures as models to study neuro-immune interactions the context of and discusses their advantages limitations. The field basic research places scientists an ethical dilemma. We aim understand underlying mechanisms for improved therapy animals. At same time, this regularly includes induction model Within psychoneuroimmunology, examination complexity health disease well bi-directional communication between brain periphery make animal experiments inevitable part research. To address legal considerations growing societal awareness welfare, push identification characterization complementary methods implement 3R principle Russel Burch. As such,

Language: Английский

Why PNI scientists need to engage in exploratory hypothesis-generating biomarker studies

Brain Behavior & Immunity - Health, Journal Year: 2024, Volume and Issue: 42, P. 100904 - 100904

Published: Nov. 9, 2024

Multi-omics research is developing rapidly, offering extensive sample analysis options and advanced statistical solutions to identify understand complex networks of biomarkers. This review encourages groups in the psychoneuroimmunology field with limited experience

Language: Английский