Hormonal gene expression changes in the zebrafish caudal neurosecretory system under acute environmental challenges

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Abstract The caudal neurosecretory system (CNSS) is neuroendocrine complex, found only in fishes, and suggested to be involved osmoregulation thermoregulation. Despite its physiological significance, the CNSS has been understudied, functional role remains enigmatic. While zebrafish ( Danio rerio ) a well-established model organism for studies, so far, of not really investigated this species. In present study, we attempted identify environmental factors whose variations induce changes activity. Juvenile were submitted acute (2 h, 8 24 h) pH, salinity, temperature challenges activity was quantified by measuring hormonal gene expression levels quantitative PCR. Our findings revealed that challenge affected larger number followed salinity pH challenge. This that, zebrafish, thermoregulation, which consistent with what reported other species, showed relevant study function CNSS.

Language: Английский

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Effects of environmental salinity on global and endocrine‐specific transcriptomic profiles in the caudal neurosecretory system of salmonid fishes

The FASEB Journal, Journal Year: 2025, Volume and Issue: 39(6)

Published: March 20, 2025

Abstract The caudal neurosecretory system (CNSS) is a fish‐specific neuroendocrine complex whose function(s) remain uncertain despite over 60 years of research. Osmoregulatory roles for the CNSS have been hypothesized, but molecular regulation following changes in environmental salinity remains poorly characterized. Therefore, we performed transcriptomics on rainbow trout ( Oncorhynchus mykiss ) to establish: (1) how responds seawater (SW) transfer, and (2) which endocrine systems contribute osmoregulatory responses CNSS. Responses SW transfer varied at 24 h versus 168 h, with primarily affecting membrane transport transcriptional processes neuronal h. Components several osmoregulation‐associated were affected (e.g., corticosteroid receptors), including some that not previously identified calcitonin). Additionally, transcript levels corticotropin‐releasing factor (CRF) peptides—which functions highly abundant CNSS—were approximately twofold higher after SW. additional experiments investigating CRF peptides more euryhaline salmonid, Atlantic salmon Salmo salar ). Smolts had up 12‐fold peptide transcripts than parr, abundance declined transfer. lower freshwater SW‐acclimated salmon. These results suggest acutely aid coordinating physiological fluctuations via anticipatory and/or responsive mechanisms. Collectively, our data indicate CNSS‐mediated production has provide resource investigations novel functions.

Language: Английский

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Urotensin II in GIFT Nile tilapia (Oreochromis niloticus): CDS cloning, tissue distribution, and in vitro regulation of male reproduction

General and Comparative Endocrinology, Journal Year: 2025, Volume and Issue: unknown, P. 114720 - 114720

Published: April 1, 2025

Language: Английский

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CRF Peptides in Non-mammals

Published: Jan. 1, 2025

Language: Английский

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Born with Silurian global warming: Defensive role of TRPV1 in caudal neurosecretory system (CNSS) in flounder

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 144092 - 144092

Published: May 1, 2025

Language: Английский

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