Relationship between hypothyroidism and chronic kidney disease: Results from the National Health and Nutrition Examination Survey 2007 to 2012 and Mendelian randomization study DOI Creative Commons

Yin Xu,

Xinmei Wang, Guofeng Wang

et al.

Medicine, Journal Year: 2024, Volume and Issue: 103(51), P. e40925 - e40925

Published: Dec. 20, 2024

Chronic kidney disease (CKD) and hypothyroidism are prevalent chronic conditions with a generally believed correlation between them. However, large-scale population studies investigations into causation lacking. This study analyzed CKD thyroid function data from the National Health Nutrition Examination Survey database spanning 2007 to 2012 using multiple regression analyses examine hypothyroidism. Bidirectional Mendelian randomization analysis was employed investigate causal association two conditions. As stages deteriorated, there significant decrease in total triiodothyronine (TT3) free ( P < .05). no observed thyroxine thyroxine. Notably, increase thyroid-stimulating hormone levels changes were thyroglobulin, thyroglobulin antibody, peroxidase antibody levels. A relationship reduced (odds ratio [OR] = 1.0041, 95% confidence interval [CI]: 1.0007–1.0075, .0186). Conversely, reverse causality not statistically (OR 2.540, 95%CI: 0.8680–4.8603, .1014). progressed, risk of increased. function. There is The finding may be beneficial prevention prognosis patients.

Language: Английский

Association of anxiety status and anxiety duration with constipation in adult Americans: a cross-sectional study using data from the NHANES 2007–2010 DOI Creative Commons
Xinran Li,

Conghui Bian,

Hui Dai

et al.

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 22, 2025

Constipated patients may exhibit anxious behaviors, but the relationship between two remains unclear. This population-based study aims to investigate relationships of anxiety status and duration with constipation among U.S. adults. Using data from National Health Nutrition Examination Survey (NHANES) database spanning 2007 2010, a cross-sectional included 8945 participants was performed assess constipation. Participants' characteristics were presented using mean or proportion. Adjusted odds ratios (ORs) 95% confidence intervals (CIs) calculated multivariable logistic regression models. The analysis accounted for potential confounding factors, including gender, age, race/ethnicity, education level, marital status, PIR, BMI, smoking drinking chronic diseases, dietary intake. Subgroup analyses conducted ensure stability results. Smoothed curve fitting applied both linear nonlinear associations risk. Threshold effects assessed two-piecewise Of participants, 922 reported constipation, prevalence 10.3%. After adjusting individuals exhibited an increased risk (OR: 1.49, CI: 1.28–1.73). Stratified indicated that association remained relatively stable across different stratification levels. threshold effect revealed adults aged 20–60, while inverted U-shaped observed in those 60 older, inflection point at 10 days. variables correlated positively on left side not right. showed significant Additionally, age-dependent observed, particularly older.

Language: Английский

Citations

1
Association between tobacco smoke exposure and constipation among American adults: a National Health and Nutrition Examination Survey DOI Creative Commons
Guiyun Cui, Xia Jiao, Zhenbiao Wang

et al.

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: March 4, 2025

Studies have shown that there is a relationship between smoke exposure and constipation. However, are limited data on the associations constipation smoking or serum cotinine levels, metabolite of nicotine commonly used as marker tobacco exposure. This study thoroughly examined cross-sectional from National Health Nutrition Examination Survey (NHANES) 2005 to 2010. We applied multivariate logistic regression models assess association status, In this study, 11,651 participants were included. The average age was 48.8 ± 17.9 years. After controlling for covariates, no significant risk. According categorical analysis, incidence 36% higher in with levels 0.05 2.99 ng/mL (model 1: OR = 1.45 [1.13-1.85]; model 2: 1.44 [1.12-1.83]; 3: 1.36 [1.06-1.74]; p < 0.05) after adjusting covariates by using lowest (<0.05 ng/mL) reference. non-smokers, linearly positively associated risk (p > 0.05), remained relatively stable across all subgroups. suggests promoting effect stool frequency-related non-smokers. Therefore, avoiding passive much possible may reduce serve preventive measure treatment.

Language: Английский

Citations

0
Negative association between body roundness index and constipation: insights from NHANES DOI Creative Commons
L Chen, H. Xiao, Xueying Yu

et al.

Journal of Health Population and Nutrition, Journal Year: 2025, Volume and Issue: 44(1)

Published: May 9, 2025

The relationship between body roundness index (BRI), a metric that distinguishes heterogeneity in fat distribution, and constipation is unclear. This study the first to investigate association BRI based on National Health Nutrition Examination Survey (NHANES) United States, providing new perspective mechanisms of obesity-related gastrointestinal dysfunction. cross-sectional utilized data from NHANES conducted 2005 2010. Constipation was diagnosed Bristol Stool Form Scale (BSFS). Weighted logistic regression models were employed assess prevalence. Restricted cubic splines (RCS) piecewise linear applied evaluate non-linear relationships constipation. Propensity score matching (PSM) implemented match constipated non-constipated populations with similar baseline characteristics. Subsequent analyses correlation A total 12,732 eligible participants included. negative observed prevalence, an adjusted odds ratio (OR) 0.87 (95% CI: 0.80, 0.95) after controlling for all covariates. When categorized into quartiles (Q1-Q4), both Q3 Q4 groups exhibited significantly reduced risk compared Q1 (OR = 0.72, 95% 0.54-0.97; OR 0.63, 0.46-0.87). RCS model revealed inverse (nonlinearity test P 0.083). Subgroup identified significant interaction effects age, alcohol consumption status, hypertension (interaction < 0.05). Post PSM, patients demonstrated higher levels than non-constipation counterparts (P 0.013). An U.S. adults, suggesting lower may correlate raised incidence. underscores critical importance maintaining optimal prevention. Further research warranted elucidate underlying governing this association.

Language: Английский

Citations

0
Association between single-point insulin sensitivity estimator and heart failure in older adults: A cross-sectional study DOI Creative Commons

Xiaofeng Zhu,

Ye-Tong Mo,

Yuqi Hu

et al.

Experimental Gerontology, Journal Year: 2024, Volume and Issue: 196, P. 112578 - 112578

Published: Sept. 11, 2024

Heart failure (HF) is a condition caused by malfunction of the heart's pumping function. The single-point insulin sensitivity estimator (SPISE) index novel indicator for assessing resistance in humans. However, connection between SPISE and risk HF elderly unknown. Therefore, our study aims to evaluate older adults.

Language: Английский

Citations

1
A causal association between obesity and constipation: a two-sample bidirectional Mendelian randomization study and meta-analysis DOI Creative Commons

Xian Sun,

S. Zhang,

Xi Zhou

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 11, 2024

Observational studies suggest a potential link between obesity and constipation, but existing results are conflicting. Therefore, we conducted Mendelian randomization (MR) study meta-analysis to assess the causal relationship risk of constipation.

Language: Английский

Citations

1
Linking Factors Associated with Constipation in Obesity DOI Creative Commons

Brendan Jen‐Wei Tan,

Ling Ling Chan,

Eng-King Tan

et al.

Obesity Facts, Journal Year: 2024, Volume and Issue: 17(4), P. 372 - 373

Published: Jan. 1, 2024

Language: Английский

Citations

0
Relationship between hypothyroidism and chronic kidney disease: Results from the National Health and Nutrition Examination Survey 2007 to 2012 and Mendelian randomization study DOI Creative Commons

Yin Xu,

Xinmei Wang, Guofeng Wang

et al.

Medicine, Journal Year: 2024, Volume and Issue: 103(51), P. e40925 - e40925

Published: Dec. 20, 2024

Chronic kidney disease (CKD) and hypothyroidism are prevalent chronic conditions with a generally believed correlation between them. However, large-scale population studies investigations into causation lacking. This study analyzed CKD thyroid function data from the National Health Nutrition Examination Survey database spanning 2007 to 2012 using multiple regression analyses examine hypothyroidism. Bidirectional Mendelian randomization analysis was employed investigate causal association two conditions. As stages deteriorated, there significant decrease in total triiodothyronine (TT3) free ( P < .05). no observed thyroxine thyroxine. Notably, increase thyroid-stimulating hormone levels changes were thyroglobulin, thyroglobulin antibody, peroxidase antibody levels. A relationship reduced (odds ratio [OR] = 1.0041, 95% confidence interval [CI]: 1.0007–1.0075, .0186). Conversely, reverse causality not statistically (OR 2.540, 95%CI: 0.8680–4.8603, .1014). progressed, risk of increased. function. There is The finding may be beneficial prevention prognosis patients.

Language: Английский

Citations

0