Relationships Between NICU Infant Stressors and Childhood Behavior and Development

Advances in Neonatal Care, Journal Year: 2025, Volume and Issue: unknown

Published: March 14, 2025

Background: Preterm infants face many stressful experiences in the neonatal intensive care unit (NICU). Critical aspects of brain growth and development may be affected by stressor exposure. Longer term neurodevelopmental effects result. Purpose: The aims were to examine relationships between NICU scores childhood behavior neurodevelopment at 4 years age a cohort preterm infants. Methods: We measured daily stress events with Neonatal Infant Stress Scale (NISS) 83 over first 6 weeks life. Twenty-five these children followed up Child Behavior Checklist (CBCL) Battelle Developmental Index-Screening Test (BDI-2 ST). Results: cumulative NISS score was significantly correlated both scales unadjusted models, but CBCL BDI-2 ST not each other, suggesting they different constructs. Gestational (GA) time until full enteral feeding only consistent infant variables associated selected as covariates regression models. Only Score for Physiology Perinatal Extension (SNAPPE-II) personal-social, motor, communication, total covariate Hierarchical regressions on internalizing, externalizing, showed scales, other factors influenced relationships, including GA, SNAPPE-II, length feeding. Implications Practice Research: amount nature have impacts age. Limitations small sample size. Further larger studies are warranted. implications would ensure efforts reduce unnecessary during stay provide developmental support grow.

Language: Английский

Relationships Between NICU Infant Stress and Childhood Behavior and Development

Published: Jan. 1, 2024

Background: Premature infants face many stressful experiences while hospitalized in the Neonatal Intensive Care Unit (NICU). These include both necessary routine procedures and invasive interventions that are painful. Critical aspects of brain development may be affected by these extrauterine experiences, particularly a developmentally immature who is unable to cognitively process verbalize physiological psychological stress responses. Premature, low birth weight at risk for later developmental delays maladaptive behavior patterns, but role NICU experience plays risks has not been fully explored. Our aims were determine relationships between childhood neurodevelopment.Methods: We measured frequency daily events experienced 83 very extremely over first six weeks their life cared using Infant Stress Scale (NISS). Other measurements included multiple health, microbiome feeding data. Twenty-four children followed up four years age with home visits measure growth, along health history, parental information, short physical examination, collection stool samples. Parents completed Child Behavior Checklist (CBLCL) trained research nurse performed Battelle Developmental Index -Screening Test (BDI-2 ST) visit. Results: Nineteen 4-year-olds had complete NISS, CBCL, BDI-2 ST The cumulative NISS score was significantly related scales. CBCL correlated each other. Gestational (GA) number days until full enteral scales, Score Physiology Perinatal Extension (SNAPPE-II) ST- personal-social, motor, communication, total Hierarchical regressions on internalizing, externalizing, scores added step GA feeing second step. ST-S scales adding step, SNAPPE-II In general, addition increased proportion variance neurodevelopment did add or ST-. Conclusions: Conclusions neonatal have impacts associated meeting benchmarks 4 exhibiting negative behaviors this time life. Limitations small sample size further studies warranted.

Language: Английский

Benzylurea Protects hPDLFs Against LPS‐Induced Mitochondrial Dysfunction Through MTCH2

Oral Diseases, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 3, 2024

ABSTRACT Objective The aim of this study is to explore the mechanism benzylurea in inflammatory injury human periodontal ligament fibroblasts (hPDLFs). Methods An inflammation model hPDLFs was established using LPS. Nuclear transport nuclear transcription factor‐κB (NF‐κB), secretion cytokines, and morphology distribution F‐actin were determined. Mitochondrial function assessed by measuring mitochondrial membrane potential (MMP), permeability transition pore (mPTP), reactive oxygen species (ROS) levels. expression carrier homolog 2 (MTCH2) Cytochrome b5 type B (CYB5B) detected. Results Benzylurea alleviated effects lipopolysaccharide (LPS) on proliferation apoptosis hPDLFs. It reduced release cytokines inhibited NF‐κB translocation. improved regulating MMP preventing excessive mPTP opening. Furthermore, LPS elevated MTCH2 CYB5B However, these can be benzylurea. altered directly affected expression, activation translocation NF‐κB. Conclusion may act as an effector MTCH2, with enhancing protecting from LPS‐induced through MTCH2.

Language: Английский