Unraveling the molecular dissociation between aging and atherosclerosis: A bioinformatics approach DOI
Takahiro Kamihara,

Tomoyasu Kinoshita,

Reo Kawano

et al.

Geriatrics and gerontology international/Geriatrics & gerontology international, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Aim In clinical practice, cardiologists frequently note substantial differences in coronary artery health among patients of the same age bracket. This observation led to our investigation into identifying genes that are shared between atherosclerosis and aging, as well those specifically amplified alone. Methods Our study leveraged existing gene expression datasets from Gene Expression Omnibus (GEO), avoiding need for new experimental research involving human or animal subjects. We focused on analyzing two specific datasets: one comprising samples individuals with without atherosclerosis, other featuring people middle versus older groups. To identify significant genes, we applied a technique known weighted average difference (WAD). Results analysis identified 14 were upregulated both aging hinting at involvement type I interferon response conditions. Conversely, 408 exhibited heightened activity within atherosclerotic lesions indicated an augmentation lysosome‐related processes. While might create groundwork predisposes progression also involves distinct factors such increase lysosomal activity. Conclusions Aging encompasses more than just senescence vascular cells; it is significantly affected by extracellular interferon. The onset therefore, cannot be attributed solely aging. Instead, likely enhanced mechanisms phagocytosis heighted Geriatr Gerontol Int 2024; ••: ••–•• .

Language: Английский

Role of Epicardial Adipose Tissue in Atrial Fibrillation as an Age-Related Disease DOI Creative Commons
Takahiro Kamihara, Shinji Kaneko, Ken Tanaka

et al.

Archives of Gerontology and Geriatrics Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100159 - 100159

Published: April 1, 2025

Language: Английский

Citations

0
Deciphering the relationship between sarcopenia and aging: A combined text mining and bioinformatics approach DOI
Takahiro Kamihara, Takuya Omura, Atsuya Shimizu

et al.

Geriatrics and gerontology international/Geriatrics & gerontology international, Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

Aim Sarcopenia is recognized as an age‐related muscle disease, but there has been no comprehensive analysis of what different between normal aging and sarcopenia, with awareness the worldwide research to date. Therefore, in this study, we used text mining PubMed articles on sarcopenia focused our bioinformatics items that have identified. Methods This study compared gene‐level changes identify sarcopenia‐specific gene using high‐throughput sequencing data. In particular, was pathways mechanisms interest research, focus more these mechanisms. Results We identified common aging. Interleukin‐7 were associated both conditions. Although phagosome‐related suggested sarcopenia‐specific, significant phagosome formation, lysosome‐related mitophagy‐related groups However, genes nicotinamide adenine dinucleotide phosphate oxidase catalytic subunit family shown be possibly altered, suggesting involvement oxidative stress regulatory pathways. Conclusions A analysis, complemented by extant literature, might not characterized a failure autophagy whole, rather, disruption regulation, particularly subunit‐related at subsequent stage after phagosome‐lysosome fusion. Geriatr Gerontol Int 2025; ••: ••–•• .

Language: Английский

Citations

0
Single-cell Transcriptomic Atlas of Human Atrial Fibrillation DOI
Qiang Wang, Xiaojun He, Dongjin Wang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 11, 2024

Abstract Atrial fibrillation (AF) is becoming a significant public health challenge, presenting moderate treatment effects and high recurrence rate. The lack of complete, in-depth understanding the pathogenesis AF severely limits capability early diagnosis (and staging) development mechanism-based, individual patient-targeted therapies. Using analyses large-scale single-nucleus transcriptomes, we characterized cell-type compositions non-AF atrial appendage tissues. We identified validated disease-specific cardiac cell subpopulations primary types, analyzed their co-expression gene modules, explored differentiation subclusters, evaluated intercellular communication signals among types subclusters. Our data elucidate the disease-specific states, enriched biological functions, potential critical genes that might be markers or targets for novel interventions. study provides comprehensive evaluation cellular composition atrium reveals how expression landscape altered in human tissue. contributes to formation progression.

Language: Английский

Citations

0
Association between Atrial Fibrillation and Periodontal Disease: A Bioinformatics Analysis DOI Creative Commons
Takahiro Kamihara, Yoshihiro Kugimiya, Takuya Omura

et al.

Archives of Gerontology and Geriatrics Plus, Journal Year: 2024, Volume and Issue: unknown, P. 100093 - 100093

Published: Oct. 1, 2024

Language: Английский

Citations

0
Unraveling the molecular dissociation between aging and atherosclerosis: A bioinformatics approach DOI
Takahiro Kamihara,

Tomoyasu Kinoshita,

Reo Kawano

et al.

Geriatrics and gerontology international/Geriatrics & gerontology international, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Aim In clinical practice, cardiologists frequently note substantial differences in coronary artery health among patients of the same age bracket. This observation led to our investigation into identifying genes that are shared between atherosclerosis and aging, as well those specifically amplified alone. Methods Our study leveraged existing gene expression datasets from Gene Expression Omnibus (GEO), avoiding need for new experimental research involving human or animal subjects. We focused on analyzing two specific datasets: one comprising samples individuals with without atherosclerosis, other featuring people middle versus older groups. To identify significant genes, we applied a technique known weighted average difference (WAD). Results analysis identified 14 were upregulated both aging hinting at involvement type I interferon response conditions. Conversely, 408 exhibited heightened activity within atherosclerotic lesions indicated an augmentation lysosome‐related processes. While might create groundwork predisposes progression also involves distinct factors such increase lysosomal activity. Conclusions Aging encompasses more than just senescence vascular cells; it is significantly affected by extracellular interferon. The onset therefore, cannot be attributed solely aging. Instead, likely enhanced mechanisms phagocytosis heighted Geriatr Gerontol Int 2024; ••: ••–•• .

Language: Английский

Citations

0