A Systematic Review of the Predictive and Diagnostic Uses of Neuroinflammation Biomarkers for Epileptogenesis

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(12), P. 6488 - 6488

Published: June 12, 2024

A central role for neuroinflammation in epileptogenesis has recently been suggested by several investigations. This systematic review explores the of inflammatory mediators epileptogenesis, its association with seizure severity, and correlation drug-resistant epilepsy (DRE). The study analysed articles published JCR journals from 2019 to 2024. search strategy comprised MESH, free terms “Neuroinflammation”, selective searches following single biomarkers that had previously selected relevant literature: “High mobility group box 1/HMGB1”, “Toll-Like-Receptor 4/TLR-4”, “Interleukin-1/IL-1”, “Interleukin-6/IL-6”, “Transforming growth factor beta/TGF-β”, “Tumour necrosis factor-alpha/TNF-α”. These queries were all combined MESH “Epileptogenesis” “Epilepsy”. We found 243 related neuroinflammation, 356 biomarker type. After eliminating duplicates, 324 evaluated, 272 excluded 55 evaluated authors. total 21 included qualitative evaluation, including 18 case–control studies, 2 case series, 1 prospective study. As conclusion, this provides acceptable support five biomarkers, TNF-α some soluble receptors (sTNFr2), HMGB1, TLR-4, CCL2 IL-33. Certain receptors, cytokines, chemokines are examples neuroinflammation-related may be crucial early diagnosis refractory or connected control epileptic seizures. Their value will better defined future studies.

Language: Английский

Epigenetic Biomarkers in Alzheimer's Disease: Diagnostic and Prognostic Relevance

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 102, P. 102556 - 102556

Published: Oct. 30, 2024

Language: Английский