Frontiers in Cardiovascular Medicine,
Journal Year:
2022,
Volume and Issue:
9
Published: April 15, 2022
Chest
pain
is
a
common
symptom
in
patients
with
systemic
lupus
erythematosus,
an
autoimmune
disease
that
associated
increased
cardiovascular
morbidity
and
mortality.
While
chest
mechanisms
can
be
multifactorial
often
attributed
to
non-coronary
or
non-cardiac
cardiac
etiologies,
emerging
evidence
suggests
ischemia
no
obstructive
coronary
arteries
(INOCA)
prevalent
condition
artery
disease.
Coronary
microvascular
dysfunction
reported
approximately
half
of
SLE
suspected
INOCA.
In
this
mini
review,
we
highlight
the
risk
assessment,
INOCA,
diagnostic
approach
for
CMD.
Biomedicines,
Journal Year:
2022,
Volume and Issue:
10(9), P. 2274 - 2274
Published: Sept. 14, 2022
Diabetic
patients
are
frequently
affected
by
coronary
microvascular
dysfunction
(CMD),
a
condition
consisting
of
combination
altered
vasomotion
and
long-term
structural
change
to
arterioles
leading
impaired
regulation
blood
flow
in
response
changing
cardiomyocyte
oxygen
requirements.
The
pathogenesis
this
complication
is
complex
not
completely
known,
involving
several
alterations
among
which
hyperglycemia
insulin
resistance
play
particularly
central
roles
oxidative
stress,
inflammatory
activation
barrier
function
endothelium.
CMD
significantly
contributes
cardiac
events
such
as
angina
or
infarction
without
obstructive
artery
disease,
well
heart
failure,
especially
the
phenotype
associated
with
preserved
ejection
fraction,
greatly
impact
cardiovascular
(CV)
prognosis.
To
date,
no
treatments
specifically
target
vascular
damage,
but
recent
experimental
studies
some
clinical
investigations
have
produced
data
favor
potential
beneficial
effects
on
micro
vessels
caused
two
classes
glucose-lowering
drugs:
glucagon-like
peptide
1
(GLP-1)-based
therapy
inhibitors
sodium-glucose
cotransporter-2
(SGLT2).
purpose
review
describe
pathophysiological
mechanisms,
manifestations
particular
reference
diabetes,
summarize
protective
antidiabetic
drugs
myocardial
compartment.
Current Cardiology Reports,
Journal Year:
2023,
Volume and Issue:
25(6), P. 561 - 570
Published: April 17, 2023
Abstract
Purpose
of
Review
Myocardial
infarction
with
nonobstructive
coronary
arteries
(MINOCA)
is
defined
as
acute
myocardial
(MI)
angiographically
no
obstructive
artery
disease
or
stenosis
≤
50%.
MINOCA
diagnostically
challenging
and
complex,
making
it
difficult
to
manage
effectively.
This
condition
accounts
for
6–8%
all
MI
poses
an
increased
risk
morbidity
mortality
after
diagnosis.
Prompt
recognition
targeted
management
are
essential
improve
outcomes
our
understanding
this
condition,
but
process
not
yet
standardized.
article
offers
a
comprehensive
review
MINOCA,
delving
deep
into
its
unique
clinical
profile,
invasive
noninvasive
diagnostic
strategies
evaluating
in
light
the
lack
widespread
availability
testing,
current
evidence
surrounding
therapies
patients
MINOCA.
Recent
Findings
uncommon
requires
assessment
using
various
imaging
modalities
evaluate
further.
Summary
heterogenous
working
diagnosis
that
thoughtful
approach
diagnose
underlying
responsible
Current Atherosclerosis Reports,
Journal Year:
2023,
Volume and Issue:
25(8), P. 435 - 446
Published: June 20, 2023
Abnormal
structure
and
function
of
the
coronary
microvasculature
have
been
implicated
in
pathophysiology
multiple
cardiovascular
disease
processes.
This
article
reviews
recent
research
progress
related
to
microvascular
dysfunction
(CMD)
salient
clinical
takeaways.
Cell Reports Medicine,
Journal Year:
2024,
Volume and Issue:
5(5), P. 101556 - 101556
Published: May 1, 2024
Cardiovascular
disease
plays
a
central
role
in
the
electrical
and
structural
remodeling
of
right
atrium,
predisposing
to
arrhythmias,
heart
failure,
sudden
death.
Here,
we
dissect
with
single-nuclei
RNA
sequencing
(snRNA-seq)
spatial
transcriptomics
gene
expression
changes
human
ex
vivo
atrial
tissue
pericardial
fluid
ischemic
disease,
myocardial
infarction,
non-ischemic
failure
using
asymptomatic
patients
valvular
who
undergo
preventive
surgery
as
control
group.
We
reveal
substantial
differences
disease-associated
all
cell
types,
collectively
suggesting
inflammatory
microvascular
dysfunction
composition
vascular
diseases
progress
into
failure.
The
data
suggest
that
investigation
cardiovascular
should
expand
functionally
important
parts
heart,
which
may
help
us
identify
mechanisms
promoting
more
severe
types
disease.
Hellenic Journal of Cardiology,
Journal Year:
2024,
Volume and Issue:
79, P. 70 - 83
Published: May 31, 2024
Acute
myocardial
infarction
(AMI)
usually
represents
the
clinical
manifestation
of
atherothrombotic
coronary
artery
disease
(CAD)
resulting
from
atherosclerotic
plaque
rupture.
However,
there
are
cases
in
which
angiography
or
computed
tomography
reveals
patients
with
acute
syndrome
non-obstructive
CAD.
This
entity
is
defined
as
arteries
(MINOCA)
and
often
considered
a
dynamic
working
diagnosis
that
needs
further
investigations
for
establishment
final
etiologic
diagnosis.
The
main
causes
MINOCA
include
atherosclerotic,
non-atherosclerotic
(vessel-related
non-vessel-related),
thromboembolic
literature
review
aimed
to
investigate
major
presenting
regarding
their
etiology
pathophysiologic
mechanisms,
well
diagnostic
treatment
methods.
Arteriosclerosis Thrombosis and Vascular Biology,
Journal Year:
2023,
Volume and Issue:
43(5), P. 774 - 783
Published: March 23, 2023
Clonal
hematopoiesis
(CH)
of
indeterminate
potential
(CHIP)
is
a
risk
factor
for
cardiovascular
disease.
The
relationship
between
CHIP
and
coronary
microvascular
dysfunction
(CMD)
unknown.
current
study
examines
the
association
CH
with
CMD
relationships
in
adverse
outcomes.
MedComm,
Journal Year:
2023,
Volume and Issue:
4(6)
Published: Dec. 1, 2023
Abstract
Since
the
four
working
groups
of
Chinese
Society
Cardiology
issued
first
expert
consensus
on
coronary
microvascular
diseases
(CMVD)
in
2017,
international
documents
CMVD
have
increased
rapidly.
Although
some
these
made
preliminary
recommendations
for
diagnosis
and
treatment
CMVD,
they
did
not
provide
classification
levels
evidence.
In
order
to
summarize
recent
progress
field
standardize
methods
procedures
treatment,
identify
scientific
questions
future
research,
updated
2017
version
adopted
a
series
measures
ensure
quality
this
document.
The
current
has
raised
new
summarized
epidemiological
findings
different
types
analyzed
key
pathological
molecular
mechanisms,
evaluated
classical
novel
diagnostic
technologies,
recommended
pathways
criteria,
therapeutic
strategies
medications,
patients
with
CMVD.
view
knowledge
gaps
directions
were
proposed.
It
is
hoped
that
will
further
expedite
research
both
basic
clinical
scenarios.
