medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Oct. 7, 2023
Abstract
Background
Systemic
chronic
inflammation
plays
a
role
in
the
pathophysiology
of
both
heart
failure
with
preserved
ejection
fraction
(HFpEF)
and
metabolic
dysfunction-associated
fatty
liver
disease
(MAFLD).
Aim
This
study
aimed
to
investigate
whether
serum
high-sensitivity
C-reactive
protein
(hs-CRP)
levels
were
associated
future
risk
(HF)
hospitalization
patients
MAFLD
normal
left
ventricular
(LVEF).
Methods
The
enrolled
consecutive
individuals
LVEF
who
underwent
coronary
angiography
for
suspected
disease.
population
was
subdivided
into
non-HF,
pre-HFpEF,
HFpEF
groups
at
baseline.
outcome
first
HF.
Results
In
10,019
middle-aged
(mean
age
63.3±10.6
years;
38.5%
female),
prevalence
rates
pre-HFpEF
34.2%
34.5%,
median
hs-CRP
level
4.5
mg/L
(IQR:
1.9-10
mg/L)
5.0
2.1-10.1
mg/L),
respectively.
Serum
significantly
higher
than
non-HF
group.
HF
hospitalizations
occurred
1942
(19.4%)
over
3.2
years,
3.7%
20.8%
32.1%
HFpEF,
Cox
regression
analyses
showed
that
highest
quartile
had
∼4.5-fold
increased
being
hospitalized
compared
those
lowest
(adjusted-Hazard
Ratio
4.42,
95%
CI
3.72-5.25).
Conclusions
There
high
baseline
subjects
MAFLD.
an
elevated
levels.
Journal of Clinical Medicine,
Journal Year:
2024,
Volume and Issue:
13(21), P. 6523 - 6523
Published: Oct. 30, 2024
The
introduction
of
CT
scans
and
the
subsequent
Agatston
score
in
1990s
drastically
improved
our
ability
to
detect
coronary
artery
calcification
(CAC).
This
led
its
incorporation
into
cardiovascular
risk
assessment
guidelines
set
forth
by
organizations
such
as
American
Heart
Association
(AHA)
College
Cardiology
(ACC).
Over
time,
these
have
evolved
significantly,
reflecting
an
increasing
understanding
CAC.
Physical
activity
has
become
a
key
factor
management
disease.
However,
relationship
between
physical
CAC
remains
complex.
Although
is
generally
beneficial
for
health,
paradoxically,
high
levels
been
associated
with
elevated
scores.
higher
may
indicate
presence
more
stable,
calcified
plaques
that
provide
protection
against
plaque
rupture.
These
contradictory
findings
call
balanced
interpretations
acknowledge
benefits
activity.
review
examines
historical
development
clinical
CAC,
paradoxical
potential
underlying
mechanisms.
It
emphasizes
need
future
research
utilize
objective
measures
consistent
methodologies
better
understand
medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Oct. 7, 2023
Abstract
Background
Systemic
chronic
inflammation
plays
a
role
in
the
pathophysiology
of
both
heart
failure
with
preserved
ejection
fraction
(HFpEF)
and
metabolic
dysfunction-associated
fatty
liver
disease
(MAFLD).
Aim
This
study
aimed
to
investigate
whether
serum
high-sensitivity
C-reactive
protein
(hs-CRP)
levels
were
associated
future
risk
(HF)
hospitalization
patients
MAFLD
normal
left
ventricular
(LVEF).
Methods
The
enrolled
consecutive
individuals
LVEF
who
underwent
coronary
angiography
for
suspected
disease.
population
was
subdivided
into
non-HF,
pre-HFpEF,
HFpEF
groups
at
baseline.
outcome
first
HF.
Results
In
10,019
middle-aged
(mean
age
63.3±10.6
years;
38.5%
female),
prevalence
rates
pre-HFpEF
34.2%
34.5%,
median
hs-CRP
level
4.5
mg/L
(IQR:
1.9-10
mg/L)
5.0
2.1-10.1
mg/L),
respectively.
Serum
significantly
higher
than
non-HF
group.
HF
hospitalizations
occurred
1942
(19.4%)
over
3.2
years,
3.7%
20.8%
32.1%
HFpEF,
Cox
regression
analyses
showed
that
highest
quartile
had
∼4.5-fold
increased
being
hospitalized
compared
those
lowest
(adjusted-Hazard
Ratio
4.42,
95%
CI
3.72-5.25).
Conclusions
There
high
baseline
subjects
MAFLD.
an
elevated
levels.
