Circulation,
Journal Year:
2023,
Volume and Issue:
149(6), P. 450 - 462
Published: Nov. 12, 2023
BACKGROUND:
Sodium
glucose
cotransporter
2
inhibitors
(SGLT2i),
glucagon-like
peptide-1
receptor
agonists
(GLP-1
RA),
and
the
nonsteroidal
mineralocorticoid
antagonist
(ns-MRA)
finerenone
all
individually
reduce
cardiovascular,
kidney,
mortality
outcomes
in
patients
with
type
diabetes
albuminuria.
However,
lifetime
benefits
of
combination
therapy
these
medicines
are
not
known.
METHODS:
We
used
data
from
SGLT2i
trials
(CANVAS
[Canagliflozin
Cardiovascular
Assessment]
CREDENCE
Renal
Events
Diabetes
Established
Nephropathy
Clinical
Evaluation]),
ns-MRA
(FIDELIO-DKD
[Finerenone
Reducing
Kidney
Failure
Disease
Progression
Diabetic
Disease]
FIGARO-DKD
[Efficacy
Safety
Finerenone
Subjects
With
Type
Mellitus
Diagnosis
Disease]),
8
GLP-1
RA
to
estimate
relative
effects
versus
conventional
care
(renin-angiotensin
system
blockade
traditional
risk
factor
control)
on
outcomes.
Using
actuarial
methods,
we
then
estimated
absolute
reductions
SGLT2i,
RA,
at
least
moderately
increased
albuminuria
(urinary
albumin:creatinine
ratio
≥30
mg/g)
by
applying
treatment
participants
receiving
CANVAS
CREDENCE.
RESULTS:
Compared
care,
was
associated
a
hazard
0.65
(95%
CI,
0.55–0.76)
for
major
adverse
cardiovascular
events
(nonfatal
myocardial
infarction,
nonfatal
stroke,
or
death).
The
corresponding
reduction
over
3
years
4.4%
3.0–5.7),
number
needed
treat
23
18–33).
For
50-year-old
patient
commencing
therapy,
event–free
survival
21.1
compared
17.9
(3.2
gained
[95%
2.1–4.3]).
There
were
also
projected
gains
free
hospitalized
heart
failure
2.4–4.0]),
chronic
kidney
disease
progression
(5.5
4.0–6.7]),
death
(2.2
1.2–3.0]),
all-cause
(2.4
1.4–3.4]).
Attenuated
but
clinically
relevant
event-free
observed
analyses
assuming
50%
additive
including
1.1–3.5]),
(4.5
2.8–5.9]),
(1.8
0.7–2.8]).
CONCLUSIONS:
In
albuminuria,
has
potential
afford
overall
survival.
Journal of Hypertension,
Journal Year:
2023,
Volume and Issue:
41(12), P. 1874 - 2071
Published: June 24, 2023
Document
Reviewers:
Luis
Alcocer
(Mexico),
Christina
Antza
(Greece),
Mustafa
Arici
(Turkey),
Eduardo
Barbosa
(Brazil),
Adel
Berbari
(Lebanon),
Luís
Bronze
(Portugal),
John
Chalmers
(Australia),
Tine
De
Backer
(Belgium),
Alejandro
de
la
Sierra
(Spain),
Kyriakos
Dimitriadis
Dorota
Drozdz
(Poland),
Béatrice
Duly-Bouhanick
(France),
Brent
M.
Egan
(USA),
Serap
Erdine
Claudio
Ferri
(Italy),
Slavomira
Filipova
(Slovak
Republic),
Anthony
Heagerty
(UK),
Michael
Hecht
Olsen
(Denmark),
Dagmara
Hering
Sang
Hyun
Ihm
(South
Korea),
Uday
Jadhav
(India),
Manolis
Kallistratos
Kazuomi
Kario
(Japan),
Vasilios
Kotsis
Adi
Leiba
(Israel),
Patricio
López-Jaramillo
(Colombia),
Hans-Peter
Marti
(Norway),
Terry
McCormack
Paolo
Mulatero
Dike
B.
Ojji
(Nigeria),
Sungha
Park
Priit
Pauklin
(Estonia),
Sabine
Perl
(Austria),
Arman
Postadzhian
(Bulgaria),
Aleksander
Prejbisz
Venkata
Ram
Ramiro
Sanchez
(Argentina),
Markus
Schlaich
Alta
Schutte
Cristina
Sekib
Sokolovic
(Bosnia
and
Herzegovina),
Jonas
Spaak
(Sweden),
Dimitrios
Terentes-Printzios
Bruno
Trimarco
Thomas
Unger
(The
Netherlands),
Bert-Jan
van
den
Born
Anna
Vachulova
Agostino
Virdis
Jiguang
Wang
(China),
Ulrich
Wenzel
(Germany),
Paul
Whelton
Jiri
Widimsky
(Czech
Jacek
Wolf
Grégoire
Wuerzner
(Switzerland),
Eugene
Yang
Yuqing
Zhang
(China).
Circulation,
Journal Year:
2023,
Volume and Issue:
149(1)
Published: Nov. 30, 2023
The
"2023
ACC/AHA/ACCP/HRS
Guideline
for
the
Diagnosis
and
Management
of
Atrial
Fibrillation"
provides
recommendations
to
guide
clinicians
in
treatment
patients
with
atrial
fibrillation.
Circulation,
Journal Year:
2024,
Volume and Issue:
149(8)
Published: Jan. 24, 2024
BACKGROUND:
The
American
Heart
Association
(AHA),
in
conjunction
with
the
National
Institutes
of
Health,
annually
reports
most
up-to-date
statistics
related
to
heart
disease,
stroke,
and
cardiovascular
risk
factors,
including
core
health
behaviors
(smoking,
physical
activity,
nutrition,
sleep,
obesity)
factors
(cholesterol,
blood
pressure,
glucose
control,
metabolic
syndrome)
that
contribute
health.
AHA
Disease
Stroke
Statistical
Update
presents
latest
data
on
a
range
major
clinical
circulatory
disease
conditions
(including
brain
health,
complications
pregnancy,
kidney
congenital
rhythm
disorders,
sudden
cardiac
arrest,
subclinical
atherosclerosis,
coronary
cardiomyopathy,
failure,
valvular
venous
thromboembolism,
peripheral
artery
disease)
associated
outcomes
quality
care,
procedures,
economic
costs).
METHODS:
AHA,
through
its
Epidemiology
Prevention
Statistics
Committee,
continuously
monitors
evaluates
sources
stroke
United
States
globally
provide
current
information
available
annual
review
published
literature
year
before
writing.
2024
is
product
full
year’s
worth
effort
2023
by
dedicated
volunteer
clinicians
scientists,
committed
government
professionals,
staff
members.
strives
further
understand
help
heal
problems
inflicted
structural
racism,
public
crisis
can
significantly
damage
mental
perpetuate
disparities
access
education,
income,
housing,
several
other
vital
healthy
lives.
This
edition
includes
additional
global
data,
as
well
monitoring
benefits
population,
an
enhanced
focus
equity
across
key
domains.
RESULTS:
Each
chapters
focuses
different
topic
statistics.
CONCLUSIONS:
represents
critical
resource
for
lay
public,
policymakers,
media
clinicians,
care
administrators,
researchers,
advocates,
others
seeking
best
these
conditions.
Circulation,
Journal Year:
2022,
Volume and Issue:
145(18)
Published: April 1, 2022
The
"2022
AHA/ACC/HFSA
Guideline
for
the
Management
of
Heart
Failure"
replaces
"2013
ACCF/AHA
and
"2017
ACC/AHA/HFSA
Focused
Update
2013
Failure."
2022
guideline
is
intended
to
provide
patient-centric
recommendations
clinicians
prevent,
diagnose,
manage
patients
with
heart
failure.A
comprehensive
literature
search
was
conducted
from
May
2020
December
2020,
encompassing
studies,
reviews,
other
evidence
on
human
subjects
that
were
published
in
English
MEDLINE
(PubMed),
EMBASE,
Cochrane
Collaboration,
Agency
Healthcare
Research
Quality,
relevant
databases.
Additional
clinical
trials
research
through
September
2021,
also
considered.
This
harmonized
American
Association/American
College
Cardiology
guidelines
2021.
Structure:
failure
remains
a
leading
cause
morbidity
mortality
globally.
provides
based
contemporary
treatment
these
patients.
present
an
evidence-based
approach
managing
failure,
intent
improve
quality
care
align
patients'
interests.
Many
earlier
have
been
updated
new
evidence,
created
when
supported
by
data.
Value
statements
are
provided
certain
treatments
high-quality
economic
analyses.
Circulation,
Journal Year:
2023,
Volume and Issue:
148(9)
Published: July 20, 2023
AIM:
The
“2023
AHA/ACC/ACCP/ASPC/NLA/PCNA
Guideline
for
the
Management
of
Patients
With
Chronic
Coronary
Disease”
provides
an
update
to
and
consolidates
new
evidence
since
“2012
ACCF/AHA/ACP/AATS/PCNA/SCAI/STS
Diagnosis
Stable
Ischemic
Heart
corresponding
“2014
ACC/AHA/AATS/PCNA/SCAI/STS
Focused
Update
Disease.”
METHODS:
A
comprehensive
literature
search
was
conducted
from
September
2021
May
2022.
Clinical
studies,
systematic
reviews
meta-analyses,
other
on
human
participants
were
identified
that
published
in
English
MEDLINE
(through
PubMed),
EMBASE,
Cochrane
Library,
Agency
Healthcare
Research
Quality,
selected
databases
relevant
this
guideline.
STRUCTURE:
This
guideline
evidenced-based
patient-centered
approach
management
patients
with
chronic
coronary
disease,
considering
social
determinants
health
incorporating
principles
shared
decision-making
team-based
care.
Relevant
topics
include
general
approaches
treatment
decisions,
guideline-directed
therapy
reduce
symptoms
future
cardiovascular
events,
pertaining
revascularization
recommendations
special
populations,
patient
follow-up
monitoring,
gaps,
areas
need
research.
Where
applicable,
based
availability
cost-effectiveness
data,
cost–value
are
also
provided
clinicians.
Many
previously
guidelines
have
been
updated
evidence,
created
when
supported
by
data.
Circulation,
Journal Year:
2023,
Volume and Issue:
148(20), P. 1606 - 1635
Published: Oct. 9, 2023
Cardiovascular-kidney-metabolic
health
reflects
the
interplay
among
metabolic
risk
factors,
chronic
kidney
disease,
and
cardiovascular
system
has
profound
impacts
on
morbidity
mortality.
There
are
multisystem
consequences
of
poor
cardiovascular-kidney-metabolic
health,
with
most
significant
clinical
impact
being
high
associated
incidence
disease
events
is
a
prevalence
in
population,
disproportionate
burden
seen
those
adverse
social
determinants
health.
However,
there
also
growing
number
therapeutic
options
that
favorably
affect
function,
or
both
have
cardioprotective
effects.
To
improve
related
outcomes
critical
need
for
(1)
more
clarity
definition
syndrome;
(2)
an
approach
to
staging
promotes
prevention
across
life
course;
(3)
prediction
algorithms
include
exposures
relevant
health;
(4)
strategies
management
relation
reflect
harmonization
major
subspecialty
guidelines
emerging
scientific
evidence.
It
incorporate
considerations
into
care
models
syndrome
reduce
fragmentation
by
facilitating
approaches
patient-centered
interdisciplinary
care.
This
presidential
advisory
provides
guidance
definition,
staging,
paradigms,
holistic
patients
details
multicomponent
vision
effectively
equitably
enhancing
population.
New England Journal of Medicine,
Journal Year:
2022,
Volume and Issue:
387(13), P. 1185 - 1195
Published: Aug. 27, 2022
Whether
acetazolamide,
a
carbonic
anhydrase
inhibitor
that
reduces
proximal
tubular
sodium
reabsorption,
can
improve
the
efficiency
of
loop
diuretics,
potentially
leading
to
more
and
faster
decongestion
in
patients
with
acute
decompensated
heart
failure
volume
overload,
is
unclear.
JAMA,
Journal Year:
2023,
Volume and Issue:
329(10), P. 827 - 827
Published: March 14, 2023
Heart
failure
with
preserved
ejection
fraction
(HFpEF),
defined
as
HF
an
EF
of
50%
or
higher
at
diagnosis,
affects
approximately
3
million
people
in
the
US
and
up
to
32
worldwide.
Patients
HFpEF
are
hospitalized
1.4
times
per
year
have
annual
mortality
rate
15%.Risk
factors
for
include
older
age,
hypertension,
diabetes,
dyslipidemia,
obesity.
Approximately
65%
patients
present
dyspnea
physical
examination,
chest
radiographic,
echocardiographic,
invasive
hemodynamic
evidence
overt
congestion
(volume
overload)
rest.
35%
"unexplained"
on
exertion,
meaning
they
do
not
clear
physical,
echocardiographic
signs
HF.
These
elevated
atrial
pressures
exercise
measured
stress
testing
estimated
Doppler
echocardiography
testing.
In
unselected
presenting
unexplained
dyspnea,
H2FPEF
score
incorporating
clinical
(age,
obesity,
fibrillation
status)
resting
(estimated
pulmonary
artery
systolic
pressure
left
pressure)
variables
can
assist
diagnosis
(H2FPEF
range,
0-9;
>5
indicates
more
than
95%
probability
HFpEF).
Specific
causes
syndrome
normal
other
should
be
identified
treated,
such
valvular,
infiltrative,
pericardial
disease.
First-line
pharmacologic
therapy
consists
sodium-glucose
cotransporter
type
2
inhibitors,
dapagliflozin
empagliflozin,
which
reduced
hospitalization
cardiovascular
death
by
20%
compared
placebo
randomized
trials.
Compared
usual
care,
training
diet-induced
weight
loss
produced
clinically
meaningful
increases
functional
capacity
quality
life
Diuretics
(typically
loop
diuretics,
furosemide
torsemide)
prescribed
improve
symptoms.
Education
self-care
(eg,
adherence
medications
dietary
restrictions,
monitoring
symptoms
vital
signs)
help
avoid
decompensation.Approximately
HFpEF.
exercise,
self-care,
diuretics
needed
maintain
euvolemia,
obesity
Circulation,
Journal Year:
2023,
Volume and Issue:
148(20), P. 1636 - 1664
Published: Oct. 9, 2023
A
growing
appreciation
of
the
pathophysiological
interrelatedness
metabolic
risk
factors
such
as
obesity
and
diabetes,
chronic
kidney
disease,
cardiovascular
disease
has
led
to
conceptualization
cardiovascular-kidney-metabolic
syndrome.
The
confluence
within
syndrome
is
strongly
linked
for
adverse
outcomes.
In
addition,
there
are
unique
management
considerations
individuals
with
established
coexisting
factors,
or
both.
An
extensive
body
literature
supports
our
scientific
understanding
of,
approach
to,
prevention
However,
critical
gaps
in
knowledge
related
terms
mechanisms
development,
heterogeneity
clinical
phenotypes,
interplay
between
social
determinants
health
biological
accurate
assessments
incidence
context
competing
risks.
There
also
key
limitations
data
supporting
care
syndrome,
particularly
early-life
prevention,
screening
interdisciplinary
models,
optimal
strategies
lifestyle
modification
weight
loss,
targeting
emerging
cardioprotective
kidney-protective
therapies,
patients
both
impact
systematically
assessing
addressing
health.
This
statement
uses
a
crosswalk
major
guidelines,
addition
review
literature,
summarize
evidence
fundamental
science,
screening,