Uncovering therapeutic targets for Pre-eclampsia and pregnancy hypertension via multi-tissue data integration

BMC Pregnancy and Childbirth, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 23, 2025

Pre-eclampsia (PE) and pregnancy hypertension (PH) are common serious complications during pregnancy, which can lead to maternal fetal death in severe cases. Therefore, further research on the potential therapeutic targets of PE PH is great significance for developing new treatment strategies. This study used summary data-based Mendelian randomization (SMR) method analyze expression quantitative trait loci (eQTL) data from blood, aorta, uterus with Genome-wide association studies (GWAS) PH, exploring genetic involved PH. Since proteinuria a clinical manifestation PE, we also analyzed genes related kidney PE. The HEIDI test was heterogeneity testing, results were adjusted using FDR. cis-eQTL obtained blood summary-level eQTLGen Consortium aorta V8 release GTEx eQTL data. GWAS FinnGen Documentation R10 release. utilized STROBE-MR checklist reporting Randomization (MR) studies. identified several by integrating uterus, as well Additionally, discovered some roles offering insights into shared pathological mechanisms these two conditions. These findings not only provide clues pathogenesis but offer crucial foundational development future revealed multiple providing basic experimental mitigate consequences Not applicable.

Language: Английский

Pharmacotherapeutic options for the treatment of hypertension in pregnancy

Expert Opinion on Pharmacotherapy, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 3, 2024

Introduction Hypertensive disorders of pregnancy affect approximately one in 10 pregnancies and are associated with increased risk adverse fetal, neonatal maternal outcomes. There is strong evidence that effective treatment hypertension (blood pressure ≥ 140/90 mmHg), enhanced monitoring throughout reduces these risks.

Language: Английский