Long Noncoding RNAs in Cardiovascular Pathology, Diagnosis, and Therapy DOI Open Access
Christian Bär, Shambhabi Chatterjee, Thomas Thum

et al.

Circulation, Journal Year: 2016, Volume and Issue: 134(19), P. 1484 - 1499

Published: Nov. 7, 2016

Vast parts of mammalian genomes encode for transcripts that are not further translated into proteins. The purpose the majority such noncoding ribonucleic acids (RNAs) remained paradoxical a long time. However, growing body evidence demonstrates RNAs dynamically expressed in different cell types, diseases, or developmental stages to execute wide variety regulatory roles at virtually every step gene expression and translation. Indeed, influence via epigenetic modulations, through regulating alternative splicing, by acting as molecular sponges. abundance cardiovascular system indicates they may be part complex network governing physiology pathology heart. In this review, we discuss multifaceted functions highlight current literature with an emphasis on cardiac development disease. Furthermore, enormous spectrum potentially opens up new avenues diagnosis prevention heart failure, ultimately evaluate futuristic prospects biomarkers, therapeutic targets treatment disorders, well.

Language: Английский

Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches DOI Open Access

Julia Beermann,

Maria-Teresa Piccoli,

Janika Viereck

et al.

Physiological Reviews, Journal Year: 2016, Volume and Issue: 96(4), P. 1297 - 1325

Published: Aug. 18, 2016

Advances in RNA-sequencing techniques have led to the discovery of thousands non-coding transcripts with unknown function. There are several types linear RNAs such as microRNAs (miRNA) and long (lncRNA), well circular (circRNA) consisting a closed continuous loop. This review guides reader through important aspects RNA biology. includes their biogenesis, mode actions, physiological function, role disease context (such cancer or cardiovascular system). We specifically focus on potential therapeutic targets diagnostic biomarkers.

Language: Английский

Citations

1582
Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology DOI Open Access
Steven J. Forrester, George W. Booz, Curt D. Sigmund

et al.

Physiological Reviews, Journal Year: 2018, Volume and Issue: 98(3), P. 1627 - 1738

Published: June 6, 2018

The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology and pathophysiology. However, many of the signaling mechanisms have been unclear. angiotensin II (ANG II) type 1 receptor (AT1R) is believed to mediate most functions ANG system. AT1R utilizes various signal transduction cascades causing hypertension, remodeling, end organ damage. Moreover, functional cross-talk between pathways other recognized. Accumulating evidence reveals complexity pathophysiology vasculature, heart, kidney, brain, as well several pathophysiological features, including inflammation, metabolic dysfunction, aging. In this review, we provide a comprehensive update events their significances for potential translation into therapeutic strategies. remains central mediating physiological II, participation specific becomes much clearer. There are still certain limitations controversies, noteworthy new concepts require further support. it expected that rigorous translational research those large animals humans will contribute establishing effective therapies against diseases.

Language: Английский

Citations

891
Analyzing MiRNA–LncRNA Interactions DOI
Maria D. Paraskevopoulou, Artemis G. Hatzigeorgiou

Methods in molecular biology, Journal Year: 2015, Volume and Issue: unknown, P. 271 - 286

Published: Dec. 31, 2015

Language: Английский

Citations

825
Long Noncoding RNAs in Cardiovascular Diseases DOI Open Access
Shizuka Uchida, Stefanie Dimmeler

Circulation Research, Journal Year: 2015, Volume and Issue: 116(4), P. 737 - 750

Published: Feb. 12, 2015

In recent year, increasing evidence suggests that noncoding RNAs play important roles in the regulation of tissue homeostasis and pathophysiological conditions. Besides small (eg, microRNAs), >200-nucleotide long transcripts, namely (lncRNAs), can interfere with gene expressions signaling pathways at various stages. cardiovascular system, studies have detected characterized expression lncRNAs under normal physiological condition disease states. Several are regulated during acute myocardial infarction Novlnc6 ) heart failure Mhrt ), whereas others control hypertrophy, mitochondrial function apoptosis cardiomyocytes. vascular endothelial-expressed MALAT1 Tie-1-AS) regulate vessel growth function, smooth-muscle–expressed lncRNA smooth muscle endothelial cell–enriched migration/differentiation-associated RNA was recently shown to contractile phenotype cells. This review article summarizes data on mouse human highlights identified might a role diseases. Although our understanding is still its infancy, these examples may provide helpful insights how

Language: Английский

Citations

705
Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets DOI
Yow Keat Tham, Bianca C. Bernardo, Jenny Y. Y. Ooi

et al.

Archives of Toxicology, Journal Year: 2015, Volume and Issue: 89(9), P. 1401 - 1438

Published: Feb. 23, 2015

Language: Английский

Citations

611
Long Noncoding RNAs DOI
Reinier A. Boon, Nicolas Jaé, Lesca M. Holdt

et al.

Journal of the American College of Cardiology, Journal Year: 2016, Volume and Issue: 67(10), P. 1214 - 1226

Published: March 1, 2016

Language: Английский

Citations

486
Long noncoding RNA LINC00336 inhibits ferroptosis in lung cancer by functioning as a competing endogenous RNA DOI Creative Commons
Min Wang, Chao Mao,

Lianlian Ouyang

et al.

Cell Death and Differentiation, Journal Year: 2019, Volume and Issue: 26(11), P. 2329 - 2343

Published: Feb. 20, 2019

The regulatory loop between long noncoding RNAs (lncRNAs) and microRNAs has a dynamic role in transcriptional translational regulation, is involved cancer. However, the circuitry lncRNAs tumorigenesis remains elusive. Here we demonstrate that nuclear lncRNA LINC00336 upregulated lung cancer functions as an oncogene by acting competing endogenous RNA (ceRNAs). bound RNA-binding protein ELAVL1 (ELAV-like 1) using nucleotides 1901–2107 of RRM interaction domain key amino acids (aa) (aa 101–213), inhibiting ferroptosis. Moreover, increased expression stabilizing its posttranscriptional level, whereas LSH (lymphoid-specific helicase) through p53 signaling pathway, further supporting hypothesis promotes expression. Interestingly, served sponge microRNA 6852 (MIR6852) to regulate cystathionine-β-synthase (CBS), surrogate marker Finally, found MIR6852 inhibited cell growth promoting These data show network ceRNA important

Language: Английский

Citations

485
Long Noncoding RNAs in Patients With Acute Myocardial Infarction DOI
Mélanie Vausort,

Daniel R. Wagner,

Yvan Devaux

et al.

Circulation Research, Journal Year: 2014, Volume and Issue: 115(7), P. 668 - 677

Published: July 18, 2014

Rationale: Long noncoding RNAs (lncRNAs) constitute a novel class of that regulate gene expression. Although recent data suggest lncRNAs may be associated with cardiac disease, little is known about in the setting myocardial ischemia. Objective: To measure patients infarction (MI). Methods and Results: We enrolled 414 acute MI treated by primary percutaneous coronary intervention. Blood samples were harvested at time reperfusion. Expression levels 5 measured peripheral blood cells quantitative polymerase chain reaction: hypoxia inducible factor 1A antisense RNA 2, cyclin-dependent kinase inhibitor 2B 1 (ANRIL), potassium voltage-gated channel, KQT-like subfamily, member opposite strand/antisense transcript (KCNQ1OT1), infarction–associated transcript, metastasis-associated lung adenocarcinoma 1. Levels KCNQ1OT1, higher than healthy volunteers ( P <0.01), ANRIL lower =0.003). Patients ST-segment–elevation had <0.001), KCNQ1OT1 =0.005) when compared non–ST-segment–elevation MI. age, diabetes mellitus, hypertension. presenting within 3 hours chest pain onset elevated 2 later on. ANRIL, significant univariable predictors left ventricular dysfunction as assessed an ejection fraction ≤40% 4-month follow-up. In multivariable reclassification analyses, improved prediction model, including demographic features, clinical parameters, biomarkers. Conclusions: are regulated after help outcome. This motivates further investigation role

Language: Английский

Citations

481
The novel regulatory role of lncRNA‐miRNA‐mRNA axis in cardiovascular diseases DOI Creative Commons
Ying Huang

Journal of Cellular and Molecular Medicine, Journal Year: 2018, Volume and Issue: 22(12), P. 5768 - 5775

Published: Sept. 6, 2018

Long noncoding RNAs (lncRNAs) are longer than 200 nt in length that characterized by low levels of sequence conservation and expression; lncRNAs modulate various biological functions at epigenetic, transcriptional post-transcriptional levels, or directly regulate protein activity. As a family small evolutionarily conserved RNAs, microRNAs (miRNAs) capable regulating physiological pathological processes via inhibiting target mRNA translation promoting degradation. A number studies have confirmed both miRNAs closely associated with the development cardiovascular diseases (CVDs), such as cardiac remodelling, heart failure, myocardial injury arrhythmia, they act biomarkers, potential therapeutic targets strong indicators prognosis; however, underlying molecular mechanism has not been elucidated. Recently, emerging evidence showed novel regulatory crosstalk among lncRNAs, mRNAs plays pivotal role pathophysiological CVDs response to stress stimuli. In this review, I comprehensively summarized relationship highlighted important lncRNA-miRNA-mRNA axis CVDs.

Language: Английский

Citations

397
Long Noncoding RNAs and MicroRNAs in Cardiovascular Pathophysiology DOI Open Access
Thomas Thum, Gianluigi Condorelli

Circulation Research, Journal Year: 2015, Volume and Issue: 116(4), P. 751 - 762

Published: Feb. 12, 2015

RNAs not encoding proteins have gained prominence over the last couple of decades as fundamental regulators cellular function. Not surprisingly, their dysregulation is increasingly being linked to pathology. Here, we review recent reports investigating pathophysiological relevance this species RNA for cardiovascular system, concentrating mainly on findings long noncoding and microRNAs in cardiac hypertrophy failure.

Language: Английский

Citations

361