Applications of Metabolomics to Precision Nutrition

Lifestyle Genomics, Journal Year: 2021, Volume and Issue: 15(1), P. 1 - 9

Published: Sept. 8, 2021

<b><i>Background:</i></b> For thousands of years, disabilities due to nutrient deficiencies have plagued humanity. Rickets, scurvy, anemia, stunted growth, blindness, and mental handicaps affected up 1/10 the world’s population prior 1900. The discovery essential amino acids, vitamins, minerals, in early 1900s, led a fundamental change our understanding food revolution human health. Widespread vitamin mineral supplementation, development recommended dietary allowances, implementation labeling testing along with significant improvements production quality meant that nutrient-related disorders almost vanished developed world. success nutritional science preventing disease at population-wide level is one great scientific triumphs 20th century. challenge for 21st century understand how use nutrients other constituents enhance health or prevent more personal level. This primary goal precision nutrition. <b><i>Summary:</i></b> Precision nutrition an emerging branch aims modern omics technologies (genomics, proteomics, metabolomics) assess individual’s response specific foods patterns thereby determine most effective diet lifestyle interventions treat diseases individual. Metabolomics vital nearly every aspect It can be used comprehensively characterize chemicals foods, identify byproducts biofluids tissues, excesses, monitor biochemical responses interventions, track long-term short-term habits, guide therapies. In this review, we will describe metabolomics has been advance field by providing some notable examples cases. First, helped launch through diagnosis therapy individuals inborn errors metabolism. Next, being full chemical complexity many key revealing much about than ever imagined. Third, consumption biomarkers opens door objective quantitative assessments their certain foods. Finally, coupled develop custom diets are leading positive benefits. <b><i>Key Message:</i></b> advancement making dream reality.

Language: Английский

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Mitochondrial protein hyperacetylation underpins heart failure with preserved ejection fraction in mice

Journal of Molecular and Cellular Cardiology, Journal Year: 2022, Volume and Issue: 165, P. 76 - 85

Published: Jan. 5, 2022

Language: Английский

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Multiomics Network Medicine Approaches to Precision Medicine and Therapeutics in Cardiovascular Diseases

Arteriosclerosis Thrombosis and Vascular Biology, Journal Year: 2023, Volume and Issue: 43(4), P. 493 - 503

Published: Feb. 16, 2023

Cardiovascular diseases (CVD) are the leading cause of death worldwide and display complex phenotypic heterogeneity caused by many convergent processes, including interactions between genetic variation environmental factors. Despite identification a large number associated genes loci, precise mechanisms which these systematically influence CVD not well understood. In addition to DNA sequence, understanding molecular requires data from other omics levels, epigenome, transcriptome, proteome, as metabolome. Recent advances in multiomics technologies have opened new precision medicine opportunities beyond genomics that can guide diagnosis personalized treatment. At same time, network has emerged an interdisciplinary field integrates systems biology science focus on among biological components health disease, providing unbiased framework through integrate data. this review, we briefly present such technologies, bulk single-cell discuss how they contribute medicine. We then highlight medicine-based integration for therapeutics CVD. also include discussion current challenges, potential limitations, future directions study using approaches.

Language: Английский

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Association between human blood metabolome and the risk of breast cancer

Breast Cancer Research, Journal Year: 2023, Volume and Issue: 25(1)

Published: Jan. 24, 2023

Abstract Background Breast cancer is the most common among women with limited treatment options. To identify promising drug targets for breast cancer, we conducted a systematical Mendelian randomization (MR) study to screen blood metabolome potential causal mediators of and further predict target-mediated side effects. Methods We selected 112 unique metabolites from 3 large-scale European ancestry-based genome-wide association studies (GWASs) total 147,827 participants. data were obtained GWAS in Cancer Association Consortium (BCAC), involving 122,977 cases 105,974 controls ancestry. MR analyses systematically assess associations phenome-wide analysis was applied ascertain on-target effects metabolite interventions. Results Two identified as including high-density lipoprotein cholesterol (HDL-C) (odds ratio [OR], 1.09; 95% confidence interval [CI], 1.06–1.12; P = 9.67 × 10 −10 ) acetate (OR, 1.24; CI, 1.13–1.37; 1.35 −5 ). In analysis, lowering HDL-C might have deleterious on risk circulatory system foreign body injury, while had mental disorders disease. Conclusions The present systematic revealed that may be developing cancer. Side-effect profiles characterized help inform target prioritization prevention. preventing but they should under weighting advantages disadvantages.

Language: Английский

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Improving 10-year cardiovascular risk prediction in patients with type 2 diabetes with metabolomics

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 13, 2025

Language: Английский

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