Microcirculation and Physical Exercise In Hypertension DOI Open Access
Carolina De Ciuceis, Damiano Rizzoni, Paolo Palatini

et al.

Hypertension, Journal Year: 2023, Volume and Issue: 80(4), P. 730 - 739

Published: Jan. 5, 2023

Hypertension is associated with important alterations in the morphology of small arteries and arterioles. Vascular-specific manifestations are changes structure function vascular smooth muscle cells, extracellular matrix, perivascular tissues, endothelial cells. Arteriole capillary remodeling rarefaction have been observed hypertensive animals human beings which contribute to increased resistance. An impairment different angiogenetic factors, such as VEGF (vascular growth factor), VEGFR-2 factor receptor-2), TIMP-1 (tissue inhibitor matrix metalloproteinases-1), TSP-1 (thrombospondin-1), seems be responsible for reduction microvascular network. Exercise training has shown improve hypertension not only large but also peripheral circulation. may regress normalize density, leading possibly by increasing proangiogenic stimuli VEGF. enhances endothelium-dependent relaxation through nitric oxide release increase oxidative stress reduction. Other mechanisms include improved balance between prostacyclin thromboxane levels, lower circulating levels endothelin-1, attenuation infiltration immune cells into adipose tissue, local adiponectin secretion. In addition, exercise favorably modulates expression several microRNAs a positive modification fiber composition. Identifying bioactive molecules biological that mediate benefits pathways differ from those used antihypertensive drugs help our knowledge pathophysiology facilitate development new therapeutic strategies.

Language: Английский

2023 ESH Guidelines for the management of arterial hypertension The Task Force for the management of arterial hypertension of the European Society of Hypertension DOI Open Access
Giuseppe Mancia, Reinhold Kreutz, Mattias Brunström

et al.

Journal of Hypertension, Journal Year: 2023, Volume and Issue: 41(12), P. 1874 - 2071

Published: June 24, 2023

Document Reviewers: Luis Alcocer (Mexico), Christina Antza (Greece), Mustafa Arici (Turkey), Eduardo Barbosa (Brazil), Adel Berbari (Lebanon), Luís Bronze (Portugal), John Chalmers (Australia), Tine De Backer (Belgium), Alejandro de la Sierra (Spain), Kyriakos Dimitriadis Dorota Drozdz (Poland), Béatrice Duly-Bouhanick (France), Brent M. Egan (USA), Serap Erdine Claudio Ferri (Italy), Slavomira Filipova (Slovak Republic), Anthony Heagerty (UK), Michael Hecht Olsen (Denmark), Dagmara Hering Sang Hyun Ihm (South Korea), Uday Jadhav (India), Manolis Kallistratos Kazuomi Kario (Japan), Vasilios Kotsis Adi Leiba (Israel), Patricio López-Jaramillo (Colombia), Hans-Peter Marti (Norway), Terry McCormack Paolo Mulatero Dike B. Ojji (Nigeria), Sungha Park Priit Pauklin (Estonia), Sabine Perl (Austria), Arman Postadzhian (Bulgaria), Aleksander Prejbisz Venkata Ram Ramiro Sanchez (Argentina), Markus Schlaich Alta Schutte Cristina Sekib Sokolovic (Bosnia and Herzegovina), Jonas Spaak (Sweden), Dimitrios Terentes-Printzios Bruno Trimarco Thomas Unger (The Netherlands), Bert-Jan van den Born Anna Vachulova Agostino Virdis Jiguang Wang (China), Ulrich Wenzel (Germany), Paul Whelton Jiri Widimsky (Czech Jacek Wolf Grégoire Wuerzner (Switzerland), Eugene Yang Yuqing Zhang (China).

Language: Английский

Citations

1507
Mechanisms of Oxidative Stress in Metabolic Syndrome DOI Open Access
Sepiso K. Masenga,

Lombe S. Kabwe,

Martin Chakulya

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(9), P. 7898 - 7898

Published: April 26, 2023

Metabolic syndrome is a cluster of conditions associated with the risk diabetes mellitus type 2 and cardiovascular diseases (CVDs). closely related to obesity. Increased adiposity promotes inflammation oxidative stress, which are precursors various complications involving metabolic components, namely insulin resistance, hypertension, hyperlipidemia. An increasing number studies confirm importance stress chronic in etiology syndrome. However, few have reviewed mechanisms underlying role contributing In this review, we highlight by reactive oxygen species (ROS) increase mitochondrial dysfunction, protein damage, lipid peroxidation, impair antioxidant function Biomarkers can be used disease diagnosis evaluation severity.

Language: Английский

Citations

254
Signaling pathways in vascular function and hypertension: molecular mechanisms and therapeutic interventions DOI Creative Commons
Jun Ma, Yanan Li, Xiangyu Yang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: April 20, 2023

Abstract Hypertension is a global public health issue and the leading cause of premature death in humans. Despite more than century research, hypertension remains difficult to cure due its complex mechanisms involving multiple interactive factors our limited understanding it. condition that named after clinical features. Vascular function factor affects blood pressure directly, it main strategy for clinically controlling BP regulate constriction/relaxation vessels. elasticity, caliber, reactivity are all characteristic indicators reflecting vascular function. Blood vessels composed three distinct layers, out which endothelial cells intima smooth muscle media performers The alterations signaling pathways these key molecular underlying dysfunction development. In this manuscript, we will comprehensively review involved regulation progression, including calcium pathway, NO-NOsGC-cGMP various remodeling some important upstream such as renin-angiotensin-aldosterone system, oxidative stress-related immunity/inflammation etc. Meanwhile, also summarize treatment methods targets discuss possibility being applied work.

Language: Английский

Citations

107
Reactive Oxygen Species Scavenging Nanomedicine for the Treatment of Ischemic Heart Disease DOI Creative Commons
Zhan Zhang, Rinkoo Dalan, Zhenyu Hu

et al.

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(35)

Published: April 26, 2022

Abstract Ischemic heart disease (IHD) is the leading cause of disability and mortality worldwide. Reactive oxygen species (ROS) have been shown to play key roles in progression diabetes, hypertension, hypercholesterolemia, which are independent risk factors that lead atherosclerosis development IHD. Engineered biomaterial‐based nanomedicines under extensive investigation exploration, serving as smart multifunctional nanocarriers for synergistic therapeutic effect. Capitalizing on cell/molecule‐targeting drug delivery, present enhanced specificity safety with favorable pharmacokinetics pharmacodynamics. Herein, ROS both IHD its discussed, highlighting cardiovascular medications antioxidant properties, summarizing advantages, recent achievements scavenging capacity treatment atherosclerosis, ischemia/reperfusion, myocardial infarction. Finally, current challenges ROS‐scavenging possible future directions discussed from a clinical perspective.

Language: Английский

Citations

105
Association between composite dietary antioxidant index and hypertension: insights from NHANES DOI Creative Commons

Mingyue Wu,

Jiayi Si,

Yihai Liu

et al.

Clinical and Experimental Hypertension, Journal Year: 2023, Volume and Issue: 45(1)

Published: July 13, 2023

The association between composite dietary antioxidant index (CDAI) and hypertension remains unknown. Our study was to investigate the of CDAI with in general adults.A total 21 526 participants were enrolled from National Health Nutrition Examination Surveys (NHANES). calculated intake six antioxidants. Multivariable logistic regressions performed explore associations prevalence hypertension. Non-linear correlations explored using restricted cubic splines. And inflection point determined by two-piecewise linear regression.In multivariate regression model full adjustment for confounding variables, odds ratio (95% confidence interval) associating 0.98 (0.97-1.00; P = .016). Besides, compared lowest quartile, highest quartile associated a lower risk (0.81 [0.70-0.94]; .006). Furthermore, found spline, 3.4 being turning point.Our highlighted negative adults.

Language: Английский

Citations

96
Oxidative stress and the role of redox signalling in chronic kidney disease DOI
Seiji Kishi, Hajime Nagasu, Kengo Kidokoro

et al.

Nature Reviews Nephrology, Journal Year: 2023, Volume and Issue: 20(2), P. 101 - 119

Published: Oct. 19, 2023

Language: Английский

Citations

88
Nanodrugs alleviate acute kidney injury: Manipulate RONS at kidney DOI Creative Commons
Qiaohui Chen,

Yayun Nan,

Yuqi Yang

et al.

Bioactive Materials, Journal Year: 2022, Volume and Issue: 22, P. 141 - 167

Published: Sept. 29, 2022

Currently, there are no clinical drugs available to treat acute kidney injury (AKI). Given the high prevalence and mortality rate of AKI, development effectively AKI is a huge unmet medical need research hotspot. Although existing evidence fully demonstrates that reactive oxygen nitrogen species (RONS) burst at site major contributor progression, heterogeneity, complexity, unique physiological structure make most antioxidant anti-inflammatory small molecule ineffective because lack targeting side effects. Recently, nanodrugs with intrinsic through control size, shape, surface properties have opened exciting prospects for treatment AKI. Many emerged address limitations current treatments. In this review, we systematically summarized first time about emerging exploit pathological features overcome traditional small-molecule achieve efficacy. First, analyzed structural characteristics main mechanism AKI: hypoxia, harmful substance accumulation-induced RONS renal despite multifactorial initiation heterogeneity Subsequently, introduced strategies used improve reviewed advances nano-RONS-sacrificial agents, nanozymes, nanocarriers antioxidants drugs. These demonstrated excellent therapeutic effects, such as greatly reducing oxidative stress damage, restoring function, low Finally, discussed challenges future directions translating into treatment.

Language: Английский

Citations

82
Oxidative Stress, Antioxidants and Hypertension DOI Creative Commons
Michael Amponsah-Offeh, Patrick Diaba‐Nuhoho, Stephan Speier

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(2), P. 281 - 281

Published: Jan. 27, 2023

As a major cause of morbidity and mortality globally, hypertension remains serious threat to global public health. Despite the availability many antihypertensive medications, several hypertensive individuals are resistant standard treatments, unable control their blood pressure. Regulation renin-angiotensin-aldosterone system (RAAS) controlling pressure, activation immune triggering inflammation production reactive oxygen species, leading oxidative stress redox-sensitive signaling, have been implicated in pathogenesis hypertension. Thus, besides which lower arterial antioxidant medications were tested improve treatment. We review discuss role pathophysiology potential use antioxidants management its associated organ damage.

Language: Английский

Citations

73
Non-coding RNAs regulating mitochondrial function in cardiovascular diseases DOI
Xiang Ao, Wei Ding, Xiaoge Li

et al.

Journal of Molecular Medicine, Journal Year: 2023, Volume and Issue: 101(5), P. 501 - 526

Published: April 4, 2023

Language: Английский

Citations

50
Catechins: Protective mechanism of antioxidant stress in atherosclerosis DOI Creative Commons
Yuhan Sheng,

Yizhuo Sun,

Yang Tang

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: March 24, 2023

Tea has long been valued for its health benefits, especially potential to prevent and treat atherosclerosis (AS). Abnormal lipid metabolism oxidative stress are major factors that contribute the development of AS. Tea, which originated in China, is believed help Research shown tea rich catechins, considered a source natural antioxidants. Catechins most abundant antioxidants green tea, be main compound responsible tea’s antioxidant activity. The properties catechins largely dependent on structure molecules, number location hydroxyl groups or their substituents. As an exogenous antioxidant, can effectively eliminate peroxidation products. They also play role indirectly by activating endogenous system regulating enzyme activity signaling pathways. In this review, we summarized preventive effect catechin AS, emphasized improving disorders key managing

Language: Английский

Citations

47