Characterization of the sex-specific pattern of angiogenesis and lymphangiogenesis in aortic stenosis DOI Creative Commons
Lara Matilla, Ernesto Martín‐Núñez, Mattie Garaikoetxea

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2022, Volume and Issue: 9

Published: Sept. 12, 2022

We aim to analyze sex-related differences in angiogenesis and lymphangiogenesis aortic valves (AVs) valve interstitial cells (VICs) from stenosis (AS) patients.Totally 230 patients (59% men) with severe AS undergoing surgical replacement were recruited. The density of total neovessels was higher AVs men as compared women. Both small medium more abundant men's AVs. Accordingly, male exhibited CD31 VE-cadherin expressions. levels the pro-angiogenic markers, such vascular endothelial growth factor (VEGF)-A, VEGF receptor (VEGFR)1, VEGFR2, insulin-like factor-binding protein-2 (IGFBP-2), interleukin (IL)-8, chemerin, fibroblast (FGF)-7, increased men. Transforming factor-β expression antiangiogenic molecules thrombospondin (Tsp)-1, endostatin, CD36 upregulated AVs, although Tsp-2, IL-4, IL-12p70, chondromodulin-1 similar between both sexes. number lymphatic vessels lymphangiogenic markers Lyve-1 D2-40 AV well VEGF-C, VEGF-D, VEGFR3. Multivariate analyses adjusted for confounders further validated sex-dependent these targets. VICs isolated secreted amounts factors, VEGF-A, VEGFR1, IGFBP-2, FGF-7, pro-lymphangiogenic VEGFR3, than women without changes markers.Our data show that aberrant angiogenic cues are over-represented Importantly, VIC is a relevant source multiple morphogens involved likely endowing predominant calcific phenotypes.

Language: Английский

Prosthesis Tailoring for Patients Undergoing Transcatheter Aortic Valve Implantation DOI Open Access
Pier Pasquale Leone, Andrea Scotti, Edwin Ho

et al.

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(1), P. 338 - 338

Published: Jan. 1, 2023

Transcatheter aortic valve implantation (TAVI) has risen over the past 20 years as a safe and effective alternative to surgical replacement for treatment of severe stenosis, is now well-established recommended option in suitable patients irrespective predicted risk mortality after surgery. Studies numerous devices, either newly developed or reiterations previous prostheses, have been accruing. We hereby review TAVI with focus on commercially available options, aim present guide prosthesis tailoring according patient-related anatomical clinical factors that may favor particular designs.

Language: Английский

Citations

11
Sex-related differences in severe native valvular heart disease: the ESC-EORP Valvular Heart Disease II survey DOI Creative Commons
Julia Mascherbauer, Andreas A. Kammerlander, Christian Nitsche

et al.

European Heart Journal, Journal Year: 2024, Volume and Issue: 45(37), P. 3818 - 3833

Published: Aug. 30, 2024

Abstract Background and Aims To assess sex differences in disease characteristics treatment of patients with severe native valvular heart (VHD) included the VHD II EURObservational Research Programme. Methods A total 5219 were enrolled 208 European North African centres followed for 6 months [41.2% aortic stenosis (AS), 5.3% regurgitation (AR), 4.5% mitral (MS), 21.3% (MR), 2.7% isolated right-sided VHD, 24.9% multiple left-sided VHD]. Indications intervention considered concordant if corresponding to class I recommendations specified 2012 ESC or 2014 AHA/ACC guidelines. Results Overall, women older, more symptomatic, presented a higher EuroSCORE II. Bicuspid valve AR prevalent among men while disease, concomitant tricuspid (TR), AS above age 65 women. On multivariable regression analysis, concordance recommended was significantly poorer MS primary MR (both P < .001). Age, patient refusal, decline symptoms after conservative reported often as reasons withhold females. Concomitant performed at similar rate both sexes although prevalence significant TR In-hospital 6-month survival did not differ between sexes. Conclusions (i) Valvular subtype varied sexes; (ii) lower women; (iii) months.

Language: Английский

Citations

4
Evolution and Prognostic Implications of Cardiac Damage in Women after Transcatheter Aortic Valve Implantation DOI
Rinchyenkhand Myagmardorj,

Federico Fortuni,

Xavier Galloo

et al.

Published: Jan. 1, 2025

IntroductionRecently, a cardiac damage staging system had been proposed in patients with severe AS to improve risk stratification, but there is still paucity of data women. Accordingly, we aimed characterize the change after transcatheter aortic valve implantation (TAVI), and assess prognostic value women.MethodsA total 334 women (mean age 81±7 years) undergoing TAVI were included. Echocardiography was performed before 6 months TAVI. Patients classified according following stages damage: 0= no damage; 1= left ventricular 2= atrial or mitral 3= pulmonary vasculature tricuspid 4= right damage. The primary endpoint all-cause mortality.ResultsMost presented advanced heart failure symptoms (62% NYHA III-IV). consistently improved at least one stage 43% 6-month follow-up. During median follow-up 55 months, 116 (35%) died. Each increment both baseline (HR per 1-stage 1.537, P= 0.001) 1.714, 0.01) independently associated death. Moreover, re-assessment provided incremental over assessment (Chi-square change= 6.885; 0.009).ConclusionTAVI has beneficial effect on function remodeling Cardiac assessed showed be prognosis.

Language: Английский

Citations

0
Sex-specific differences in infective endocarditis: A systematic review and meta-analysis of clinical profiles and management outcomes DOI Creative Commons

Heba Salim,

Yazan S. Bani Hamad,

Huda Alwadiya

et al.

IJC Heart & Vasculature, Journal Year: 2025, Volume and Issue: 56, P. 101607 - 101607

Published: Jan. 18, 2025

Language: Английский

Citations

0
Sex-related differences in hospital outcomes after balloon aortic valvuloplasty DOI
Fatima Lakhani, Bertrand Ebner,

Chetan Yarlagadda

et al.

Cardiovascular revascularization medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Cardiovascular Health in Women DOI

Aury V. Garcia,

Yorgos Strangas

Primary Care Clinics in Office Practice, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Cardiac Rehabilitation for Women with Heart Disease DOI
Jonathan Whiteson,

Sofiya Prilik,

Matthew C. Glenn

et al.

Physical Medicine and Rehabilitation Clinics of North America, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Sex differences in diagnosis and treatment of heart failure: toward precision medicine DOI Creative Commons
Soo Y. Lee, Seong‐Mi Park

The Korean Journal of Internal Medicine, Journal Year: 2025, Volume and Issue: 40(2), P. 196 - 207

Published: March 1, 2025

There are sex-related differences in the pathophysiology and phenotype of heart failure (HF) as well pharmacokinetics pharmacodynamics drugs between women men due to biological differences, such vessel size, response blood volume pressure, body water muscle compositions, dominant sex hormones. Therefore, target drug doses required achieve same clinical effect differ sexes, while there may also be side effects a given at dose. These have been reflected results trials. Moreover, underrepresented pharmacological therapy trials having lower device implantation rates than men. currently recommended medications based on not appropriate for women. Although guidelines HF standardized since last major revision 2021, most do differentiate by sex. This review focuses evidence regarding multiple aspects HF, including epidemiology, pathophysiology, features, treatment, prognosis, highlighting need sex-specific treatment guidelines.

Language: Английский

Citations

0
Exploring the Interaction Between HLA‐B27 and Other Risk Factors of Valvular Heart Disease in Axial Spondyloarthritis DOI Open Access
Yupeng Lai,

Yanpeng Zhang,

Shuo Cheng

et al.

International Journal of Rheumatic Diseases, Journal Year: 2025, Volume and Issue: 28(3)

Published: March 1, 2025

HLA-B27 plays a critical role in axial spondyloarthritis (axSpA). Valvular heart disease (VHD) is life-threatening extra-articular manifestation of axSpA. The evidence for the association between and VHD axSpA still scarce controversial. In this study, we aim to mainly explore axSpA, interaction other risk factors We analyze cross-sectional data patients from 2016 2022 Shenzhen Second People's Hospital. Multivariable logistic regression models were fitted evaluate patients. When discovering sex duration, made stratified analyses. Included 444 with echocardiography during inpatient admission. Males 299, females 145. adjusted model multivariable analysis, only age increased (OR 1.054; 95% CI 1.021-1.087). To detect interactions variables that affected outcome VHD, categorical duration found interact after being by (p < 0.05). sex-stratified male 11.2; 1.40-89.36) age. analysis over 24 months 5.86; 1.27-27.07). Our study provided was independent factor interacted increase

Language: Английский

Citations

0
Real World Sex Differences in Patients Undergoing Ascending Aortic Aneurysm Surgery—A Systematic Review and Meta-Analysis of Reconstructed Time-to-Event Data DOI Open Access
Mohammed Al‐Tawil, Alexander Geragotellis,

Ahmad Alroobi

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(6), P. 1908 - 1908

Published: March 12, 2025

Background: Men are known to have a higher incidence of acute cardiovascular events, while women recognized for their increased mortality following diagnosis or intervention these conditions. The aim this study is explore the sex differences in clinical profiles and outcomes patients undergoing ascending aortic aneurysm (AscAA) surgery. Methods: A PRISMA compliant literature search data extraction were conducted using PubMed, EMBASE, SCOPUS. Observational cohort retrospective registries that compared defined number male female adults surgery AscAA included. Data analysis was compliance with Cochrane methods. Results: total 11 unique studies met inclusion criteria, from which 13636 included, distribution 9124 males (67%) 4512 females (33%). Overall, 91% underwent elective Male had significantly lower 30-day mortality, (RR: 0.68, 95% Cl [0.57, 0.81], p < 0.0001) shorter stays intensive care unit, mean difference (MD) −0.48 days ([−0.84, −0.13], = 0.008). Males younger at time (MD: −3.94 years, CI [−5.58, −2.31], 0.00001). more frequent concomitant CABG (21% vs. 14.5%; 0.0001), isolated supra-coronary replacement (22% 36%; 0.004). Female who long-term survival (HR: 1.25, [1.05, 1.50], 0.013). Conclusions: Women undergo older ages face greater mortality. disparities preoperative age timing between can be explained by comorbidity need

Language: Английский

Citations

0