Cells,
Journal Year:
2023,
Volume and Issue:
12(20), P. 2485 - 2485
Published: Oct. 19, 2023
Three
systemic
biological
systems,
i.e.,
the
nervous,
immune,
and
cardiovascular
form
a
mutually
responsive
forward-acting
tissue
network
to
regulate
acute
chronic
function
in
health
disease.
Two
sub-circuits
within
system
have
been
described,
artery
brain
circuit
(ABC)
heart
(HBC),
forming
large
(CBC).
Likewise,
nervous
consists
of
peripheral
central
with
their
functional
distinct
sensory
effector
arms.
Moreover,
immune
its
constituents,
innate
adaptive
interact
CBC
at
multiple
levels.
As
understanding
structure
inner
workings
gains
momentum,
it
becomes
evident
that
further
research
into
may
lead
unprecedented
classes
therapies
treat
diseases
as
new
biologically
active
molecules
are
being
discovered
likely
affect
disease
progression.
Here,
we
weigh
merits
integrating
these
recent
observations
neurobiology
previous
views
pathogeneses.
These
considerations
us
propose
Neuroimmune
Cardiovascular
Circuit
Hypothesis.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(6), P. 2553 - 2553
Published: March 12, 2025
Sympathetic
nerves
innervate
bone
marrow
and
various
immune
organs,
where
norepinephrine—the
primary
sympathetic
neurotransmitter—directly
interacts
with
cells
that
express
adrenergic
receptors.
This
article
reviewed
the
key
molecular
pathways
triggered
by
activation
explored
how
activity
influences
cell
migration.
Norepinephrine
serves
as
a
chemoattractant
for
monocytes,
macrophages,
stem
cells,
promoting
migration
of
myeloid
while
inhibiting
lymphocytes
at
physiological
concentrations.
We
also
examined
role
infiltration
in
cardiovascular
diseases
cancer.
Evidence
suggests
increases
into
target
tissues
across
diseases,
including
atherosclerosis,
hypertension,
cardiac
fibrosis,
hypertrophy,
arrhythmia,
myocardial
infarction,
heart
failure,
stroke.
Conversely,
may
serve
potential
therapeutic
strategy
to
treat
these
conditions
reducing
macrophage
infiltration.
Furthermore,
promotes
accumulation
cancer
tissues,
mirroring
its
effects
suppressing
T
lymphocyte
cancerous
sites.
These
changes
contribute
increased
growth
metastasis.
Thus,
could
help
protect
against
enhancing
presence
tumors.
Frontiers in Cellular Neuroscience,
Journal Year:
2024,
Volume and Issue:
17
Published: Jan. 8, 2024
The
theory
of
engrams,
proposed
several
years
ago,
is
highly
crucial
to
understanding
the
progress
memory.
Although
it
significantly
contributes
identifying
new
treatments
for
cognitive
disorders,
limited
by
a
lack
technology.
Several
scientists
have
attempted
validate
this
but
failed.
With
increasing
availability
activity-dependent
tools,
researchers
found
traces
engram
cells.
Activity-dependent
tools
are
based
on
mechanisms
underlying
neuronal
activity
and
use
combination
emerging
molecular
biological
genetic
Scientists
used
these
tag
manipulate
neurons
identified
numerous
internal
connections
between
In
review,
we
provide
background,
principles,
selected
examples
applications
existing
tools.
Using
traditional
definitions
concepts
cells,
discuss
limitations
propose
certain
developmental
directions
further
explore
functions
