Circadian Mechanisms in Cardiovascular and Cerebrovascular Disease

Circulation Research, Journal Year: 2024, Volume and Issue: 134(6), P. 615 - 617

Published: March 14, 2024

Language: Английский

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Editorial: Function and regulation of non-neuronal cells in the nervous system

Frontiers in Cellular Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: Feb. 7, 2025

Traditionally, the nervous system has been perceived primarily as a complex network predominantly composed of neurons. Nevertheless, ongoing developments in field neuroscience have brought to light significant contributions non-neuronal cells, highlighting their importance 1,2 . Getting profound insight into functional traits and mechanisms that govern them is essential for developing innovative approaches treating preventing neurological disorders.Recently, there progress investigation cells within system. The primary emphasis lies uncovering intricate interactions connect these neurons each other. As an illustration, recent studies neurovascular coupling begun elucidate relationship between brain activity modulation blood flow cerebral [3][4][5][6] Investigations neuroimmunology introduced novel insights critical roles immune play both inflammatory response progression neurodegenerative disorders 7,8 Investigating glial serves burgeoning area study, focusing on unraveling complexities communication exchange information among astrocytes, other neurons, along with influence neural operations 2,9,10 .Microglia, resident found system, act initial barrier against invasive pathogens role upholding balance environment 11 These part processes such elimination excess synapses throughout maturation are capable rapidly triggering protective when faced injury or pathological conditions [12][13][14] Astrocytes vital not only offering structural support but also expertly managing neurotransmitter absorption release 15,16 , meticulously maintaining ion equilibrium 17,18 influencing synaptic adaptability 19 Cells unit, including endothelial pericyte populations, stability integrity blood-brain while ensuring accurate suitable regulation perfusion 20,21 .In disorders, unnormal functioning commonly identified. In Alzheimer's Parkinson's diseases, involvement astrocytes become characteristic feature [22][23][24] Additionally, impairments link function vascular responses disruptions factors development numerous stroke multiple sclerosis [25][26][27] Consequently, thorough exploration functions disease anticipated yield perspectives strategic avenues identifying new therapeutic targets.This special issue provides examination important aspects regarding Non-neuronal (mainly cells) supporting, protecting, nourishing Their ability divide makes prone mutation malignant transformation. Most tumors central originate from cells. Ji et al reported discovery Gap Junction Protein, Gamma 1(GJC1) prognostic biomarker glioma 28 GJC1 located human chromosome 17 encodes gap junction gamma -1 protein (connexin 45, Cx45), which participates intercellular communication. expression Cx45 decreased colorectal cancer tumor-suppressive melanoma its gliomas remains unclear. study systematically investigated clinicopathological features, molecular subclasses, prognosis patterns. They analyzed biological markers associated tumor further performed drug correlation analysis. Moreover, all specific action obtained analysis were related cell cycle, supporting cell-cycle regulation.The review article Zhao comprehensively stated olfactory system's complexity pivotal health 29 This discussed diverse dynamics mammalian bulb, mainly focused microglia, oligodendrocytes, ensheathing radial glia Each type contributes uniquely bulb 's functionality, many neuronal survival defense axonal guidance. features health, potential applications neuroregeneration.Traumatic (TBI) global concern characterized by elevated rates morbidity mortality. physiological changes after TBI closely microglia. Microglia, brain, linked treatment TBI. Zhang published bibliometric visualization identify current research hotspots predict future 30 this authors mechanism ischemic two aspects: repair infiltration following post-TBI peripheral immunosuppression inflammation.Ischemic accounts 75% 80% events, making it leading cause cerebrovascular diseases deaths worldwide 31 Following stroke, crucial unit functions, regulating metabolic Wang al. systemically explored trends prospects immune-related therapy 32 .To summarize, currently experiencing growth. dedicated Research Topic intended significantly advancement establishing platform academic discussions demonstration achievements.

Language: Английский

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Machine Learning Models for Subarachnoid Hemorrhagic Prognosis: A Multicenter Study Considering Circadian Rhythms and Timing Factor

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

BACKGROUND: Traditional statistical methods(e.g.,logistic regression)are widely used for prognostic prediction in SAH patients but may fail to capture complex non-linear interactions,such as between circadian rhythms and physiological parameters.Machine learning algorithms,particularly SVM with SHAP interpretability,offer a robust framework handling high-dimensional data improving predictive accuracy.This study innovatively integrates rhythm-based time intervals(4-hour segments)into the model,addressing gap existing tools. METHODS: patient were obtained from MIMIC-IV 3.1 ICU database Liaoyang Central Hospital NICU(2018–2024)and divided into training(85%)and validation(15%)sets.Risk factors screened using LASSO.Six machine models—LASSO regression,logistic regression,SVM,KNN,Decision Tree,and Random Forest—were developed evaluated via 10-fold cross-validation." RESULTS: A total of 651 analyzed(555 training,96 validation).Key including gender,age,admission time,smoking,diabetes,GCS,HR,SBP,and RPP build models.The model,chosen its high interpretability,achieved AUCs 0.9351 0.7958,and F1 scores 0.8496 0.7652,outperforming other models.A risk score calculator based on model is available at https://liuyongbo0312.shinyapps.io/myshinyapp/ CONCLUSION: This prognosis subarachnoid hemorrhage(SAH)patients identified Support Vector Machine(SVM)as optimal model.The found that onset has certain impact prognosis,offering new directions future research clinical practice. Clinicians can use by inputting patient-specific parameters(e.g.,RPP,GCS,admission segment)into provided rapidly identify high-risk targeted interventions.

Language: Английский

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Associations of compound hot extremes and heat waves with first-ever stroke morbidity in the context of climate change

Advances in Climate Change Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Blood-brain mechanics: How brain tissue responds to pulsatile blood flow dynamics

International Journal of Mechanical Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 110278 - 110278

Published: April 1, 2025

Language: Английский

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Ticking Brain: Circadian Rhythm as a New Target for Cerebroprotection

Stroke, Journal Year: 2024, Volume and Issue: 55(9), P. 2385 - 2396

Published: July 16, 2024

Circadian rhythm is a master process observed in nearly every type of cell throughout the body, and it macroscopically regulates daily physiology. Recent clinical trials have revealed effects circadian variation on incidence, pathophysiological processes, prognosis acute ischemic stroke. Furthermore, core clock genes, cell-autonomous pacemakers rhythm, affect neurovascular unit-composing cells nonparallel manner after same processes ischemia/reperfusion. In this review, we discuss influence rhythms genes each unit

Language: Английский

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