Chronobiological variations of acute aortic dissection in a Northwest Chinese population DOI Creative Commons

Ermek Tangsakar,

Rinat Imamu,

Arash Nabi

et al.

Journal of Cardiothoracic Surgery, Journal Year: 2024, Volume and Issue: 19(1)

Published: Dec. 20, 2024

The prevalence of acute aortic dissection (AAD) has been gradually increasing in recent years. This study aimed to investigate the circadian variations AAD onset a northwest Chinese population and provide scientific insights for prevention. clinical data 1,145 patients admitted our hospital between January 2010 December 2020 were retrospectively collected, periodic features analyzed. Stanford type A B present 58.43% (669 cases) 41.57% (476 patients, respectively. incidence rate was highest winter (358 cases, 31.27%) lowest summer (225 19.65%). occurred at 19:00–24:00 (321 28.03%) 1:00–6:00 (247 21.57%). most prevalent least spring, whereas summer. difference seasonal distribution significant spring (χ2 = 17.666, P < 0.001) 6.228, 0.013). cases appeared during (236 35.28%) 13:00–18:00 (73 10.91%), while (239 50.21%) (60 12.61%). period all periods time. followed chronobiological pattern from China, with being peak season time occurrence,

Language: Английский

Circadian Mechanisms in Cardiovascular and Cerebrovascular Disease DOI Open Access
Eng H. Lo, Frank M. Faraci

Circulation Research, Journal Year: 2024, Volume and Issue: 134(6), P. 615 - 617

Published: March 14, 2024

Language: Английский

Citations

9
Circadian influences on sudden cardiac death and cardiac electrophysiology DOI
Brian P. Delisle, Abhilash Prabhat, Don E. Burgess

et al.

Journal of Molecular and Cellular Cardiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Exploring potential biomarkers for acute myocardial infarction by combining circadian rhythm gene expression and immune cell infiltration DOI Creative Commons

Xiao Yu,

Xiaopeng Zhang, Hazrat Bilal

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 1, 2025

Current diagnostic biomarkers for acute myocardial infarction (AMI), such as troponins, often lack specificity, leading to false positives under non-cardiac conditions. Recent studies have implicated circadian rhythm and immune infiltration in the pathogenesis of AMI. This study hypothesizes that analyzing interplay between rhythm-related gene expression identify highly specific Our results demonstrated differential 15 genes (CRGs) AMI patients healthy individuals, with five key genes-JUN, NAMPT, S100A8, SERPINA1, VCAN identified contributors this process. Functional enrichment analyses suggest these significantly influence cytokine chemokine production responses. Immune assessments using ssGSEA indicated elevated levels neutrophils, macrophages, eosinophils patients. Additionally, we potential therapeutic implications 13 pivotal miRNAs 10 candidate drugs targeting genes. The Benjamini-Hochberg method was employed adjust multiple testing, retained statistical significance. RT-qPCR analysis further confirmed upregulation hypoxic conditions, compared controls. Collectively, our findings highlight critical role CRGs AMI, providing a foundation improved approaches novel targets.

Language: Английский

Citations

0
In Situ Mass Spectrometry Imaging to Elucidate the Effects of an Adenosine A2A Receptor Agonist and Alprazolam on Sleep Regulation DOI Creative Commons
Yi Zhang,

Guixiang Yang,

Qian Jin

et al.

ACS Pharmacology & Translational Science, Journal Year: 2025, Volume and Issue: 8(3), P. 841 - 853

Published: Feb. 20, 2025

Alprazolam (Alp), a commonly used sleep medication in clinical practice, has several potential limitations, including narrow therapeutic dosage range and delayed onset. CGS21680 (CGS), selective agonist of the adenosine A2A receptor, exhibits neuroinhibitory properties. This study aimed to evaluate effects CGS on properties Alp. The sleep-inducing Alp were assessed through righting reflex, while sedative evaluated by spontaneous activity detection. synergistic effect was using electroencephalography electromyography. results indicate that we optimized selected ED5 dose ED50 for coadministration. reduced latency induced extended duration. distribution brain mass spectrometry imaging (MSI). blood-brain barrier (BBB) model established impact transmittance indicated influenced across various regions increased Alp's BBB. metabolic pathways GABA, glutamate, glutamine MSI enzyme verification. coadministration resulted regulation during maintenance periods, respectively. In conclusion, potentiating is attributed its ability modulate enhancing BBB permeability influence Alp-induced neurotransmitter release.

Language: Английский

Citations

0
Combining Circadian Rhythm-Related Gene Expression and Immune Infiltration to Identify Diagnostic Biomarkers in Acute Myocardial Infarction DOI Creative Commons

Xiao Yu,

Xiaopeng Zhang, Hazrat Bilal

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 8, 2024

Abstract Current diagnostic biomarkers for acute myocardial infarction (AMI), such as troponins, often lack specificity, leading to false positives under non-cardiac conditions. Recent studies have implicated circadian rhythm and immune infiltration in the pathogenesis of AMI. This study hypothesizes that analyzing interplay between rhythm-related gene expression can pinpoint more accurate Our results demonstrated differential 15 genes (CRGs) AMI patients healthy individuals, with five key genes—JUN, NAMPT, S100A8, SERPINA1, VCAN—emerging central this process. Functional enrichment analyses suggest these significantly influence cytokine chemokine production responses. Immune assessments using ssGSEA indicated elevated levels neutrophils, macrophages, eosinophils patients. Additionally, we identified potential therapeutic implications 13 pivotal miRNAs 10 candidate drugs targeting genes. RT-qPCR analysis further confirmed upregulation hypoxic conditions, compared controls. Collectively, our findings highlight critical role CRGs AMI, offering new insights into its diagnosis targets.

Language: Английский

Citations

0
Circadian (Diurnal/Nocturnal) Pattern of Cardiac Arrhythmias DOI

Antonis A. Manolis,

Theodora A. Manolis, Antonis S. Manolis

et al.

Heart Rhythm, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Citations

0
Chronobiological variations of acute aortic dissection in a Northwest Chinese population DOI Creative Commons

Ermek Tangsakar,

Rinat Imamu,

Arash Nabi

et al.

Journal of Cardiothoracic Surgery, Journal Year: 2024, Volume and Issue: 19(1)

Published: Dec. 20, 2024

The prevalence of acute aortic dissection (AAD) has been gradually increasing in recent years. This study aimed to investigate the circadian variations AAD onset a northwest Chinese population and provide scientific insights for prevention. clinical data 1,145 patients admitted our hospital between January 2010 December 2020 were retrospectively collected, periodic features analyzed. Stanford type A B present 58.43% (669 cases) 41.57% (476 patients, respectively. incidence rate was highest winter (358 cases, 31.27%) lowest summer (225 19.65%). occurred at 19:00–24:00 (321 28.03%) 1:00–6:00 (247 21.57%). most prevalent least spring, whereas summer. difference seasonal distribution significant spring (χ2 = 17.666, P < 0.001) 6.228, 0.013). cases appeared during (236 35.28%) 13:00–18:00 (73 10.91%), while (239 50.21%) (60 12.61%). period all periods time. followed chronobiological pattern from China, with being peak season time occurrence,

Language: Английский

Citations

0