Circadian Mechanisms in Cardiovascular and Cerebrovascular Disease

Circulation Research, Journal Year: 2024, Volume and Issue: 134(6), P. 615 - 617

Published: March 14, 2024

Language: Английский

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Biological Fluid Flows: Signaling Mediums for Circadian Timing

Journal of Biological Rhythms, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

While there is extensive literature on both the neuronal circuitry of rhythms and intracellular molecular clock, a large component signaling that has been understudied: interstitial fluid (ISF)—fluid surrounds cells in extracellular space tissue. In this review, we highlight evidence circadian supporting ISF as key to synchronization entrainment propose new mechanisms how movement between brain periphery may act zeitgebers by examining main pathways body, focusing regulation glymphatic lymphatic systems. We identify pieces research point an important timing medium, expand basics cerebrospinal (CSF) production, outline basic structure function

Language: Английский

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Melatonin Regulates Glymphatic Function to Affect Cognitive Deficits, Behavioral Issues, and Blood–Brain Barrier Damage in Mice After Intracerebral Hemorrhage: Potential Links to Circadian Rhythms

CNS Neuroscience & Therapeutics, Journal Year: 2025, Volume and Issue: 31(2)

Published: Feb. 1, 2025

ABSTRACT Background Intracerebral hemorrhage (ICH) is a life‐threatening cerebrovascular disorder with no specific pharmacological treatment. ICH causes significant behavioral deficits and cognitive impairments. Recent research suggests that circadian rhythm regulation could be promising therapeutic strategy for ICH. Melatonin has been shown to alleviate glymphatic system (GS) dysfunction by regulating rhythms, thereby improving depressive‐like behaviors postoperative sleep disorders in mice. However, its application treatment mechanisms are not well understood. Methods models were created 8‐to‐10‐week‐old mice using collagenase injection. Circadian modulation was tested melatonin luzindole. Behavioral impairments assessed the modified neurological severity score, corner test, novel object recognition test. Brain water content measured dry/wet weight method, cerebral perfusion blood flow measurements. GS function evaluated RITC‐dextran Evans blue assays. Immunofluorescence western blotting used analyze BBB permeability. Results restored transport after ICH, promoting hematoma edema absorption, reducing damage, outcomes. luzindole partially blocked these benefits reversed neuroprotective effects. Conclusion affect function, permeability, cognitive‐behavioral outcomes The underlying mechanism may involve of rhythms.

Language: Английский

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Global Clock Coordination by the Brain Clock in the Suprachiasmatic Nucleus Through Relay and Amplification of Diffusible and Neural Signaling

European Journal of Neuroscience, Journal Year: 2025, Volume and Issue: 61(8)

Published: April 1, 2025

ABSTRACT The brain clock located in the suprachiasmatic nucleus (SCN) of hypothalamus receives direct retinal input, thereby providing entire body with an internal representation external solar time. pathways by which this small signals so broadly involve co‐occurring nervous and diffusible output signals, although latter are less understood. Portal pathways, such as well‐known pituitary portal pathway, provide a mechanism, whereby neural origin can reach local, specialized targets without suffering dilution systemic blood supply. Newly discovered vascular connections between each sensory circumventricular nuclei at its point attachment to brain. These line brain's ventricles, their leaky vessels large perivascular spaces represent route, secretions from SCN be relayed then amplified, pathway achieve global coordination circadian signaling. This review provides narrative that incorporates our understanding particular emphasis on contribution fluidic compartments fluids therein.

Language: Английский

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Influencing factors of glymphatic system during perioperative period

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Sept. 12, 2024

The glymphatic system is a functional cerebrospinal fluid circulatory that uses peri-arterial space for inflow of and peri-venous efflux from brain parenchyma. This brain-wide transport pathway facilitates the exchange between interstitial clears metabolic waste metabolically active brain. Multiple lines work show crucial to normal functions, dysfunction closely associated with various neurological disorders, including aging, neurodegeneration, acute injury. Currently, it common explore molecular mechanisms based on animal models. function during perioperative period affected by many factors such as physiological, pathological, anesthetic operative methods. To provide reference interpretation results studies period, this article comprehensively reviews physiological pathological interfere investigates effects drugs potential underlying mechanisms, describes methods system, intervention strategies system. Future, these variables should be taken into account critical covariates in design

Language: Английский

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Bilinear-form and similarity-reduction visit to a variable-coefficient generalized dispersive water-wave system concerning Acta Mech. 233, 2527 and 233, 2415

Acta Mechanica, Journal Year: 2024, Volume and Issue: 235(7), P. 4915 - 4923

Published: May 18, 2024

Language: Английский

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