Circadian Mechanisms in Cardiovascular and Cerebrovascular Disease

Circulation Research, Journal Year: 2024, Volume and Issue: 134(6), P. 615 - 617

Published: March 14, 2024

Language: Английский

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Circadian clock gene BMAL1 is involved in transforming growth factor β1‐induced fibrotic response in NRK‐49F cells

Cell Biology International, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

The transcription factor brain and muscle Arnt-like protein-1 (BMAL1) is a clock protein involved in various diseases, including atherosclerosis cancer. However, BMAL1's involvement kidney fibrosis the underlying mechanisms remain largely unknown, gap addressed this study. Analysis through Masson's trichrome Sirius red staining revealed that all groups exposed to unilateral ureteral obstruction showed increased BMAL1 expression accompanied by TGF-β1 elevated key markers, α-SMA, compared with sham groups. Although induced α-SMA NRK-49F cells, REV-ERBα agonist GSK4112, transcriptional repressor of BMAL1, or siRNA targeting significantly inhibited TGF-β1-induced expression. Furthermore, knockdown suppressed NOX4/ROS/p38 pathways cells. Thus, positively regulates signaling associated fibrotic responses via pathway. Overall, study uncovers as promising therapeutic target for preventing treating fibrosis, potentially renal failure.

Language: Английский

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Circadian biology of cardiac aging

Journal of Molecular and Cellular Cardiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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On the imperative of including 24-hour and longitudinal multidimensional physiological phenotyping in rodent models of sleep apnea

Sleep Medicine, Journal Year: 2025, Volume and Issue: 127, P. 133 - 137

Published: Jan. 18, 2025

Language: Английский

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Circadian rhythm gene cryptochrome 2 (Cry2) interacts with lipid metabolism to promote vascular aging

Archives of Gerontology and Geriatrics, Journal Year: 2025, Volume and Issue: 131, P. 105761 - 105761

Published: Jan. 22, 2025

Language: Английский

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Impact of Renal Denervation on Circadian Variations of Blood Pressure and Clock Gene Expression in Spontaneously Hypertensive Rats

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Hypertension is often associated with elevated nighttime blood pressure (BP), a significant risk factor for cardiovascular and cerebrovascular diseases. This study explores the effects of renal denervation (RDN) on circadian BP rhythms clock gene expression in spontaneously hypertensive rats (SHR). Ten-week-old SHR were randomized into RDN sham surgery (Sham) groups, Wistar-Kyoto (WKY) as controls. was measured at rest (14:00) during activity (02:00) biweekly, variability analyzed. significantly reduced BP, particularly resting phase, thereby enhancing variation. The Sham group displayed minimal variation plasma norepinephrine levels, whereas exhibited an overall reduction norepinephrine, lower levels than activity. Furthermore, showed no renin-angiotensin-aldosterone system (RAS), restored ACE1, Ang II, ACE2, Ang1-7. Additionally, demonstrated consistently high BMAL1 protein expression, indicating These findings suggest that not only lowers but also improves its rhythm, likely through modulation sympathetic nervous activity, RAS system, BMAL1.

Language: Английский

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Conceptualizing myocardial contractility as an emergent property that characterizes myocardial contraction

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 16

Published: April 16, 2025

Myocardial contractility (MC) is a fundamental concept that widely used to describe the cardiac muscles' mechanical function, yet its definitions in textbooks and literature are vague, inconsistent, often contradictory. In this article, we categorize these many issues into five groups conducts conceptual analysis redefine MC from broader, more comprehensive perspective. We propose functional, three-domain framework of consisting capacity/resource, adaptability, ability (force (F) and/or velocity (V) generated during muscle contraction), emphasizing dynamic, non-linear interactions among three domains their clinical significance. Specifically, highlight how interventions targeting may produce effects, suggesting shift toward optimizing resource use rather than maximizing outputs (i.e., F V myocardial contraction, domain), which could potentially reduce complications positive inotropic interventions. also discuss implications several new developments as byproducts framework. Additionally, identify system-level emergent properties briefly, including contraction efficiency, circadian rhythm-dependence, temperature-dependence, history-dependence, with for research, exercise training, decision-making. The functional resolves inconsistencies definitions, differentiates performance, offers structured perspective facilitating both experimental studies therapeutic strategies.

Language: Английский

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Exercise-mediated muscle-hypothalamus crosstalk: Improvement for cognitive dysfunction caused by disrupted circadian rhythm

Life Sciences, Journal Year: 2025, Volume and Issue: 373, P. 123657 - 123657

Published: April 28, 2025

Language: Английский

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The potential roles of exosomes in pathological cardiomyocyte hypertrophy mechanisms and therapy: A review

Medicine, Journal Year: 2024, Volume and Issue: 103(17), P. e37994 - e37994

Published: April 26, 2024

Pathological cardiac hypertrophy, characterized by the enlargement of muscle cells, leads to serious conditions and stands as a major global health issue. Exosomes, comprising small lipid bilayer vesicles, are produced various cell types found in numerous bodily fluids. They play pivotal role intercellular communication transferring bioactive cargos recipient cells or activating signaling pathways target cells. Exosomes from cardiomyocytes, endothelial fibroblasts, stem key regulating processes like cardiomyocyte survival, apoptosis, fibrosis, angiogenesis within context cardiovascular diseases. This review delves into exosomes' roles pathological first elucidating their impact on pathways. It then advances discuss how exosomes affect hypertrophic processes, including metabolism, oxidative stress, angiogenesis. The culminates evaluating potential biomarkers significance targeted therapeutic strategies, thus emphasizing critical pathophysiology management hypertrophy.

Language: Английский

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Misalignment between circadian preference and accelerometer-derived actual sleep-wake cycle is associated with increased risk of cardiometabolic diseases: a prospective cohort study in UK Biobank

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 28, 2024

Background: Evidence has linked several circadian disruption indicators to adverse health outcomes, however, associations of misalignment between preference and actual sleep-wake cycle with cardiometabolic diseases (CMDs) remains unclear. We aimed prospectively investigate the CMDs including type 2 diabetes (T2D), chronic heart (CHD), stroke, uncover potential mechanisms linking CMDs. Methods: A total 60,965 participants from UK Biobank study without baseline followed-up for an average 7.9 years were included in current analysis. Circadian was defined as discrepancies self-reported chronotype accelerometer-derived midpoint sleep. Incident derived multiple medical source data. Cox proportional hazards regression models used compute hazard ratio (HR) confidence intervals (CIs) on association incident Results: U-shaped found T2D CHD after adjusting confounders. Compared individuals aligned midsleep preferences, those advanced delayed had higher risks [HRs (95%CI)s 1.22 (1.03, 1.45) 1.39 (1.18, 1.62)]. However, only significantly associated increased risk [HR (95%CI) 1.16 (1.02, 1.33)]. Liver function, lipid glucose metabolism, inflammatory markers partially explained observed (mediation proportion 12.3-44.6% T2D, 8.8-20.5% CHD). Additionally, early (95%CI): 1.19 (1.06, 1.34)] rather than late T2D. Conclusion: Both CMDs, suggesting benefits aligning cycles individual preferences.

Language: Английский

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