The Common Hallmarks of Aging, Circadian Rhythms and Cancer: Implications for Therapeutic Strategies

Research, Journal Year: 2025, Volume and Issue: 8

Published: Jan. 1, 2025

The intricate relationship between cancer, circadian rhythms, and aging is increasingly recognized as a critical factor in understanding the mechanisms underlying tumorigenesis cancer progression. Aging well-established primary risk for while disruptions rhythms are intricately associated with progression of various tumors. Moreover, itself disrupts leading to physiological changes that may accelerate development. Despite these connections, specific interplay processes their collective impact on remains inadequately explored literature. In this review, we systematically explore influence We discuss how core genes tumor prognosis, highlighting shared hallmarks such genomic instability, cellular senescence, chronic inflammation. Furthermore, examine aging, focusing crosstalk contributes tumorigenesis, proliferation, apoptosis, well metabolism stability. By elucidating common pathways linking review provides new insights into pathophysiology identifies potential therapeutic strategies. propose targeting regulation could pave way novel treatments, including chronotherapy antiaging interventions, which offer important benefits clinical management cancer.

Language: Английский

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Circadian Mechanisms in Cardiovascular and Cerebrovascular Disease

Circulation Research, Journal Year: 2024, Volume and Issue: 134(6), P. 615 - 617

Published: March 14, 2024

Language: Английский

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Circadian Rhythm-Dependent Therapy by Composite Targeted Polyphenol Nanoparticles for Myocardial Ischemia-Reperfusion Injury

ACS Nano, Journal Year: 2024, Volume and Issue: 18(41), P. 28154 - 28169

Published: Oct. 7, 2024

Myocardial ischemia-reperfusion (IR) injury is a severe rhythmic disease with high prevalence in the early morning. IR has significant circadian rhythm reactive oxygen species (ROS) and inflammation levels. The development of drugs become priority myocardial injury. In this study, resveratrol (RES) proanthocyanidins (OPC) were utilized to design nanoparticles (NPs), hyaluronic acid (HA) as core, grafted MMP-targeting peptides improve delivery injured regions (HA-RES-OPC-MMP NPs). NPs significantly scavenged ROS, attenuated inflammation, activated gene. Notably, difference therapeutic effects on mice at Zeitgeber time (ZT)1 ZT13 confirms that are rhythm-dependent drugs. At ZT13, echocardiographic MRI confirm was not ZT1, yet also less effective treatment. Further,

Language: Английский

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Circadian rhythm gene cryptochrome 2 (Cry2) interacts with lipid metabolism to promote vascular aging

Archives of Gerontology and Geriatrics, Journal Year: 2025, Volume and Issue: 131, P. 105761 - 105761

Published: Jan. 22, 2025

Language: Английский

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Exploring potential biomarkers for acute myocardial infarction by combining circadian rhythm gene expression and immune cell infiltration

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 1, 2025

Current diagnostic biomarkers for acute myocardial infarction (AMI), such as troponins, often lack specificity, leading to false positives under non-cardiac conditions. Recent studies have implicated circadian rhythm and immune infiltration in the pathogenesis of AMI. This study hypothesizes that analyzing interplay between rhythm-related gene expression identify highly specific Our results demonstrated differential 15 genes (CRGs) AMI patients healthy individuals, with five key genes-JUN, NAMPT, S100A8, SERPINA1, VCAN identified contributors this process. Functional enrichment analyses suggest these significantly influence cytokine chemokine production responses. Immune assessments using ssGSEA indicated elevated levels neutrophils, macrophages, eosinophils patients. Additionally, we potential therapeutic implications 13 pivotal miRNAs 10 candidate drugs targeting genes. The Benjamini-Hochberg method was employed adjust multiple testing, retained statistical significance. RT-qPCR analysis further confirmed upregulation hypoxic conditions, compared controls. Collectively, our findings highlight critical role CRGs AMI, providing a foundation improved approaches novel targets.

Language: Английский

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Role of circadian transcription factor REV-ERB in cardiovascular diseases: a review

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12

Published: April 4, 2025

Circadian rhythm, or the biological clock, is an intrinsic timing system present in organisms that operates on a cycle of approximately 24 h. Nearly every cell human body adheres to specific circadian governing various processes essential for overall health. REV-ERB, key clock-regulating gene, plays crucial role maintaining precision these rhythms. This gene influences many downstream targets associated with diverse pathophysiological processes, including metabolism, autophagy, immunity, inflammation, and aging across multiple organs. REV-ERB specifically impacts cardiac systolic function by regulating myocardial energy metabolism. In contemporary society, health well-being are increasingly challenged disruptions such as night shifts, late-night activities, jet lag. These often lead rhythm disorders, which now being linked heart diseases. review explored potential cardiovascular system. Beyond its regulation, could significantly influence physiological pathological related health, atherosclerosis, ischemia/reperfusion injury, failure. Mechanistically, regulate glucose lipid ferroptosis, mitochondrial function. The highlighted protective roles underlying mechanisms diseases, suggesting multidisciplinary research may provide basis breakthroughs REV-ERB-targeted therapies disorders.

Language: Английский

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On the imperative of including 24-hour and longitudinal multidimensional physiological phenotyping in rodent models of sleep apnea

Sleep Medicine, Journal Year: 2025, Volume and Issue: 127, P. 133 - 137

Published: Jan. 18, 2025

Language: Английский

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Sustained Release of Dual p38 Inhibitors via Supramolecular Hydrogels to Enhance Cardiac Repair after MI/R Injury

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

Activation of p38 mitogen-activated protein kinase plays an important role in the progression ventricular muscle inflammation after myocardial ischemia-reperfusion (MI/R). The inhibition activation ischemic myocardium can reduce remodeling post-MI. However, owing to dynamic change MI, clinical therapeutic effect inhibitors is insufficient. Herein, we describe design a hydrogelator Nap-Phe-Phe-Thr-Gly-Tyr-OH (Nap-TGY) coassemble inhibitor SB202190 (SB), responsive supramolecular hydrogel (Gel Nap-TGY+SB) for local administration and release SB efficiently improve inflammatory microenvironment. Under overexpression myocardium, Nap-TGY phosphorylated yield hydrophilic Nap-Phe-Phe-Thr(H2PO3)-Gly-Tyr(H2PO3) (Nap-TpGYp), triggering disassembly inhibitor. Injection into significantly reduces phosphorylation, mitigates inflammation, enhances angiogenesis. These findings suggest novel strategy cardiomyopathy through modulation (MAPK) pathway.

Language: Английский

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Sustained Release of Dual P38 Inhibitors Via Supramolecular Hydrogels to Enhance Cardiac Repair after Mi/R Injury

Published: Jan. 1, 2025

Language: Английский

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The beneficial health effects of puerarin in the treatment of cardiovascular diseases: from mechanisms to therapeutics

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: 397(10), P. 7273 - 7296

Published: May 6, 2024

Language: Английский

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